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Hdac7
Gene Detail
Symbol

Name
ID
Hdac7
histone deacetylase 7
MGI:1891835
Synonyms
5830434K02Rik, Hdac7a
Feature Type
protein coding gene
Genetic Map
Chromosome 15
53.79 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:97792664-97844502 bp, - strand
From VEGA annotation of GRCm38

  51839 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HDAC7
Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac7

Human
homologs
HDAC7, histone deacetylase 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51564
neXtProt AC: NX_Q8WUI4

Human Synonyms: HD7, HD7A, HDAC7A

Human Chr (Location): 12q13.1; chr12:47782722-47820612 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hdac7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
 
Phenotype Images(2)
Interactions
Hdac7 interacts with 184 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process B cell activation, B cell differentiation, ...
Component cytoplasm, histone deacetylase complex, ...
Function 14-3-3 protein binding, activating transcription factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (48)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
Western blot 6
RT-PCR 38
cDNA source data(102)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HDAC7 ; Xenbase hdac7    NEW 
Molecular
reagents
All nucleic(104) cDNA(102) Primer pair(2)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029597 VEGA Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
transcript OTTMUST00000073417 VEGA | MGI Sequence Detail 4113 Not Applicable 
polypeptide OTTMUSP00000037987 VEGA | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(34) UniProt(10)
Polymorphisms
SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008486 histone deacetylase 7
References
(Earliest) J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
(Latest) J:218396 Bradley EW, et al., Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and beta-catenin activity during endochondral ossification. J Biol Chem. 2015 Jan 2;290(1):118-26
All references(57)
Other
accession IDs
MGI:2443780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory