About   Help   FAQ
Hdac7 Gene Detail
Summary
  • Symbol
    Hdac7
  • Name
    histone deacetylase 7
  • Synonyms
    5830434K02Rik, Hdac7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891835
    NCBI Gene: 56233
  • Gene Overview
    MyGene.info: HDAC7
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:97792664-97844502 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      51839 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 53.79 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC7, histone deacetylase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HD7, HD7A, HDAC7A
  • Links
    NCBI Gene ID: 51564
    neXtProt AC: NX_Q8WUI4
    UniProt: Q8WUI4

  • Chr Location
    12q13.11; chr12:47782710-47820612 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    48
  • Tissues
    14
  • cDNA Data
    103
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029597 VEGA Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
    transcript OTTMUST00000073417 VEGA | MGI Sequence Detail 4113 Not Applicable  
    polypeptide OTTMUSP00000037987 VEGA | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      301 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 103
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443780
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 15
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:264161 Kasler HG, et al., Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells. Elife. 2018 Apr 17;7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory