Hdac7
Gene Detail

Symbol Name ID

Hdac7 histone deacetylase 7 MGI:1891835

Synonyms

5830434K02Rik, Hdac7a

Feature Type

protein coding gene

Genetic Map

Chromosome 15

53.79 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:97792664-97844502 bp, - strand From VEGA annotation of GRCm38   51839 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac7

Human homologs

Human Homolog		HDAC7, histone deacetylase 7
NCBI Gene ID		51564
neXtProt AC		NX_Q8WUI4
Human Synonyms		HD7A, HDAC7A
Human Chr (Location)		12q13.1; chr12:47782722-47820416 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hdac7 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.

 

Interactions

Hdac7 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	B cell activation, B cell differentiation, ...
Component	cytoplasm, histone deacetylase complex, ...
Function	14-3-3 protein binding, activating transcription factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (48)    Tissues (13)   
Theiler Stages: 2, 3, 17, 19, 20, 21, 23, 25, 26, 28

Assay Type	Results
RNA in situ	4
Western blot	6
RT-PCR	38

cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(104) cDNA(102) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029597 (Evidence)
Ensembl Gene Model	ENSMUSG00000022475 (Evidence)
Entrez Gene	56233 (Evidence)
UniGene	384027
DFCI	TC1575128, TC1592272, TC1593845, TC1593876, TC1595908, TC1606386, TC1616640, TC1625868
DoTS	DT.101159626, DT.101388446, DT.101388448, DT.101738707, DT.101738708, DT.40147781, DT.91308439, DT.91312973, DT.91558119, DT.97409113, DT.97409121, DT.99844062
NIA Mouse Gene Index	U098954
EC	3.5.1.98
Consensus CDS Project	CCDS37188.1, CCDS57001.1, CCDS57002.1, CCDS57003.1, CCDS57004.1, CCDS57005.1, CCDS57006.1, CCDS57007.1
International Mouse Knockout Project Status	Hdac7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029597	VEGA Gene Model | MGI Sequence Detail	51839	C57BL/6J
transcript	OTTMUST00000073417	VEGA | MGI Sequence Detail	4113	Not Applicable
polypeptide	OTTMUSP00000037987	VEGA | MGI Sequence Detail	953	Not Applicable

All sequences(152) RefSeq(46) UniProt(10)

Polymorphisms

SNPs within 2kb(307 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017320	Histone deacetylase class II, eukaryotic
InterPro	IPR023801	Histone deacetylase domain
InterPro	IPR000286	Histone deacetylase superfamily
Protein Ontology	PR:000008486	histone deacetylase 7

References

(Earliest) J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
(Latest) J:203317 Su YT, et al., Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013 Apr;33(8):1546-60
All references(56)

Other accession IDs

MGI:2443780