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Hdac7 Gene Detail
Summary
  • Symbol
    Hdac7
  • Name
    histone deacetylase 7
  • Synonyms
    5830434K02Rik, Hdac7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891835
    NCBI Gene: 56233
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97690545-97742383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 53.79 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891835
protein coding gene Chr15:97690542-97742383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022280
protein coding gene Chr15:99465444-99507879 (-)
A/J MGP_AJ_G0022239
protein coding gene Chr15:95533819-95574293 (-)
AKR/J MGP_AKRJ_G0022214
protein coding gene Chr15:98414236-98454348 (-)
BALB/cJ MGP_BALBcJ_G0022245
protein coding gene Chr15:95757001-95795945 (-)
C3H/HeJ MGP_C3HHeJ_G0022015
protein coding gene Chr15:98493343-98534064 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022690
protein coding gene Chr15:103138698-103179682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020216
protein coding gene Chr15:91478723-91518221 (-)
CAST/EiJ MGP_CASTEiJ_G0021537
protein coding gene Chr15:99361993-99417824 (-)
CBA/J MGP_CBAJ_G0021982
protein coding gene Chr15:106598351-106636744 (-)
DBA/2J MGP_DBA2J_G0022109
protein coding gene Chr15:94983147-95021766 (-)
FVB/NJ MGP_FVBNJ_G0022088
protein coding gene Chr15:93971602-94014533 (-)
LP/J MGP_LPJ_G0022180
protein coding gene Chr15:99573572-99617751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022108
protein coding gene Chr15:110717983-110757656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022705
protein coding gene Chr15:98564440-98602708 (-)
PWK/PhJ MGP_PWKPhJ_G0021278
protein coding gene Chr15:95080411-95134676 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021112
protein coding gene Chr15:98335366-98376620 (-)
WSB/EiJ MGP_WSBEiJ_G0021586
protein coding gene Chr15:99083874-99138478 (-)



Homology
more
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Synonyms
    HD7, HD7A, HDAC7A
  • Links
    NCBI Gene ID: 51564
    neXtProt AC: NX_Q8WUI4
    UniProt: Q8WUI4

  • Chr Location
    12q13.11; chr12:47782722-47833132 (-)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022475 Ensembl Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
    transcript ENSMUST00000116409 Ensembl | MGI Sequence Detail 4113 Not Applicable  
    polypeptide ENSMUSP00000112110 Ensembl | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 103
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443780
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 11
      Phenotypes 38
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:343966 Velasco-Aviles S, et al., A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair. Elife. 2022 Jan 25;11:e72917

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory