Hdac7 MGI Mouse Gene Detail - MGI:1891835

Symbol

Hdac7
Name

histone deacetylase 7
Synonyms

5830434K02Rik, Hdac7a

Feature Type

protein coding gene
IDs

MGI:1891835
NCBI Gene: 56233
Gene Overview

MyGene.info: HDAC7
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:97792664-97844502 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 53.79 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

301 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891835	protein coding gene	Chr15:97792664-97844502 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022280	protein coding gene	Chr15:99465444-99507879 (-)
A/J	MGP_AJ_G0022239	protein coding gene	Chr15:95533819-95574293 (-)
AKR/J	MGP_AKRJ_G0022214	protein coding gene	Chr15:98414236-98454348 (-)
BALB/cJ	MGP_BALBcJ_G0022245	protein coding gene	Chr15:95757001-95795945 (-)
C3H/HeJ	MGP_C3HHeJ_G0022015	protein coding gene	Chr15:98493343-98534064 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022690	protein coding gene	Chr15:103138698-103179682 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020216	protein coding gene	Chr15:91478723-91518221 (-)
CAST/EiJ	MGP_CASTEiJ_G0021537	protein coding gene	Chr15:99361993-99417824 (-)
CBA/J	MGP_CBAJ_G0021982	protein coding gene	Chr15:106598351-106636744 (-)
DBA/2J	MGP_DBA2J_G0022109	protein coding gene	Chr15:94983147-95021766 (-)
FVB/NJ	MGP_FVBNJ_G0022088	protein coding gene	Chr15:93971602-94014533 (-)
LP/J	MGP_LPJ_G0022180	protein coding gene	Chr15:99573572-99617751 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022108	protein coding gene	Chr15:110717983-110757656 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022705	protein coding gene	Chr15:98564440-98602708 (-)
PWK/PhJ	MGP_PWKPhJ_G0021278	protein coding gene	Chr15:95080411-95134676 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021112	protein coding gene	Chr15:98335366-98376620 (-)
WSB/EiJ	MGP_WSBEiJ_G0021586	protein coding gene	Chr15:99083874-99138478 (-)

Human Ortholog

HDAC7, histone deacetylase 7

Vertebrate Orthologs

10

Human Ortholog

HDAC7, histone deacetylase 7
Orthology source: HomoloGene, HGNC
Synonyms

HD7, HD7A, HDAC7A
Links

HGNC:14067

NCBI Gene ID: 51564

neXtProt AC: NX_Q8WUI4

UniProt: Q8WUI4
Chr Location

12q13.11; chr12:47782710-47820612 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9124
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HDAC7
Protein SuperFamily

histone deacetylase class II, eukaryotic type
Gene Tree

Hdac7

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Hdac7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.

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All GO Annotations

39
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

48
Tissues

14
cDNA Data

103
Literature Summary

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HDAC7

Xenbase hdac7

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Hdac7 interacts with 184 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

117
RefSeq

37
UniProt

10
CCDS

CCDS37188.1, CCDS57001.1, CCDS57002.1, CCDS57003.1, CCDS57004.1, CCDS57005.1, CCDS57006.1, CCDS57007.1
UniGene

384027

Ensembl

ENSMUSG00000022475 (Evidence)
NCBI Gene

56233

			Length	Strain/Species	Flank
genomic	56233	NCBI Gene Model \| MGI Sequence Detail	51839	C57BL/6J	± kb
transcript	NM_001204276	RefSeq \| MGI Sequence Detail	4387	C57BL/6
polypeptide	Q8C2B3	UniProt \| EBI \| MGI Sequence Detail	938	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000008486 histone deacetylase 7

(term hierarchy)
EC

3.5.1.98
InterPro Domains

IPR033660 Histone deacetylase 4

IPR017320 Histone deacetylase class II, eukaryotic

IPR023801 Histone deacetylase domain

IPR037138 Histone deacetylase domain superfamily

IPR000286 Histone deacetylase family

IPR023696 Ureohydrolase domain superfamily

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All nucleic 105

cDNA 103

Primer pair 2

Microarray probesets 4

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MGI:2443780

Summaries

All 86

Developmental Gene Expression 15

Diseases 1

Gene Ontology 15

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:264161 Kasler HG, et al., Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells. Elife. 2018 Apr 17;7

TSS for Hdac7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136174	Chr15:97844912-97844935 (-)	-422 bp
Tssr136173	Chr15:97844254-97844318 (-)	216 bp
Tssr136172	Chr15:97844234-97844245 (-)	262 bp
Tssr136171	Chr15:97831537-97831580 (-)	12,943 bp
Tssr136170	Chr15:97831460-97831519 (-)	13,012 bp
Tssr136164	Chr15:97814830-97814878 (-)	29,648 bp
Tssr136162	Chr15:97808415-97808431 (-)	36,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14