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Hdac7
Gene Detail
 Symbol
Name
ID
Hdac7
histone deacetylase 7
MGI:1891835
Synonyms 5830434K02Rik, Hdac7a
Feature Type protein coding gene
Genetic Map
Chromosome 15
53.79 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:97792664-97844502 bp, - strand
From VEGA annotation of GRCm38

  51839 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac7

Human
homologs
Human Homolog HDAC7, histone deacetylase 7
NCBI Gene ID 51564
neXtProt AC  NX_Q8WUI4
Human Synonyms  HD7A, HDAC7A
Human Chr (Location)  12q13.1; chr12:47782722-47820416 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hdac7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
 
Interactions
Hdac7 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process B cell activation, B cell differentiation, ...
Component cytoplasm, histone deacetylase complex, ...
Function 14-3-3 protein binding, activating transcription factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (48)    Tissues (13)   
Theiler Stages: 2, 3, 17, 19, 20, 21, 23, 25, 26, 28
Assay TypeResults
RNA in situ 4
Western blot 6
RT-PCR 38
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) cDNA(102) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029597 (Evidence)
Ensembl Gene ModelENSMUSG00000022475 (Evidence)
Entrez Gene56233 (Evidence)
UniGene384027
DFCITC1575128, TC1592272, TC1593845, TC1593876, TC1595908, TC1606386, TC1616640, TC1625868
DoTSDT.101159626, DT.101388446, DT.101388448, DT.101738707, DT.101738708, DT.40147781, DT.91308439, DT.91312973, DT.91558119, DT.97409113, DT.97409121, DT.99844062
NIA Mouse Gene IndexU098954
EC3.5.1.98
Consensus CDS ProjectCCDS37188.1, CCDS57001.1, CCDS57002.1, CCDS57003.1, CCDS57004.1, CCDS57005.1, CCDS57006.1, CCDS57007.1
International Mouse Knockout Project StatusHdac7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029597 VEGA Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
transcript OTTMUST00000073417 VEGA | MGI Sequence Detail 4113 Not Applicable 
polypeptide OTTMUSP00000037987 VEGA | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(152) RefSeq(46) UniProt(10)
Polymorphisms SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017320 Histone deacetylase class II, eukaryotic
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008486 histone deacetylase 7
References (Earliest) J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
(Latest) J:203317 Su YT, et al., Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013 Apr;33(8):1546-60
All references(56)
Other
accession IDs
MGI:2443780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory