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Hdac7 Gene Detail
Summary
  • Symbol
    Hdac7
  • Name
    histone deacetylase 7
  • Synonyms
    5830434K02Rik, Hdac7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891835
    NCBI Gene: 56233
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97690545-97742383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 53.79 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2605 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891835
 protein coding gene Chr15:97690542-97742383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022280
 protein coding gene Chr15:99465444-99507879 (-)
A/J MGP_AJ_G0022239
 protein coding gene Chr15:95533819-95574293 (-)
AKR/J MGP_AKRJ_G0022214
 protein coding gene Chr15:98414236-98454348 (-)
BALB/cJ MGP_BALBcJ_G0022245
 protein coding gene Chr15:95757001-95795945 (-)
C3H/HeJ MGP_C3HHeJ_G0022015
 protein coding gene Chr15:98493343-98534064 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022690
 protein coding gene Chr15:103138698-103179682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020216
 protein coding gene Chr15:91478723-91518221 (-)
CAST/EiJ MGP_CASTEiJ_G0021537
 protein coding gene Chr15:99361993-99417824 (-)
CBA/J MGP_CBAJ_G0021982
 protein coding gene Chr15:106598351-106636744 (-)
DBA/2J MGP_DBA2J_G0022109
 protein coding gene Chr15:94983147-95021766 (-)
FVB/NJ MGP_FVBNJ_G0022088
 protein coding gene Chr15:93971602-94014533 (-)
LP/J MGP_LPJ_G0022180
 protein coding gene Chr15:99573572-99617751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022108
 protein coding gene Chr15:110717983-110757656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022705
 protein coding gene Chr15:98564440-98602708 (-)
PWK/PhJ MGP_PWKPhJ_G0021278
 protein coding gene Chr15:95080411-95134676 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021112
 protein coding gene Chr15:98335366-98376620 (-)
WSB/EiJ MGP_WSBEiJ_G0021586
 protein coding gene Chr15:99083874-99138478 (-)



Homology
more
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Synonyms
    HD7, HD7A, HDAC7A
  • Links
    NCBI Gene ID: 51564
    UniProt: Q8WUI4

  • Chr Location
    12q13.11; chr12:47782722-47833132 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    25
  • cDNA Data
    103
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022475 Ensembl Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
    transcript ENSMUST00000116409 Ensembl | MGI Sequence Detail 4113 Not Applicable  
    polypeptide ENSMUSP00000112110 Ensembl | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443780
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 18
      Phenotypes 41
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:361223 Ye J, et al., Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis. Mol Neurodegener. 2025 Jan 13;20(1):5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory