About   Help   FAQ
Hdac7
Gene Detail
Symbol

Name
ID
Hdac7
histone deacetylase 7
MGI:1891835
Synonyms
5830434K02Rik, Hdac7a
Feature Type
protein coding gene
Genetic Map
Chromosome 15
53.79 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:97792664-97844502 bp, - strand
From VEGA annotation of GRCm38

  51839 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac7

Human
homologs
Human Homolog HDAC7, histone deacetylase 7
NCBI Gene ID 51564
neXtProt AC  NX_Q8WUI4
Human Synonyms  HD7A, HDAC7A
Human Chr (Location)  12q13.1; chr12:47782722-47820416 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hdac7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
 
Interactions
Hdac7 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process B cell activation, B cell differentiation, ...
Component cytoplasm, histone deacetylase complex, ...
Function 14-3-3 protein binding, activating transcription factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (48)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
Western blot 6
RT-PCR 38
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) cDNA(102) Primer pair(2)
Microarray probesets(4)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029597 VEGA Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
transcript OTTMUST00000073417 VEGA | MGI Sequence Detail 4113 Not Applicable 
polypeptide OTTMUSP00000037987 VEGA | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(161) RefSeq(46) UniProt(19)
Polymorphisms
SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017320 Histone deacetylase class II, eukaryotic
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008486 histone deacetylase 7
References
(Earliest) J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
(Latest) J:203317 Su YT, et al., Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013 Apr;33(8):1546-60
All references(56)
Other
accession IDs
MGI:2443780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory