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Hdac7 Gene Detail
Summary
  • Symbol
    Hdac7
  • Name
    histone deacetylase 7
  • Synonyms
    5830434K02Rik, Hdac7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891835
    NCBI Gene: 56233
  • Gene Overview
    MyGene.info: HDAC7
Location & Maps
more
  • Sequence Map
    Chr15:97792664-97844502 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      51839 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 53.79 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HDAC7, histone deacetylase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC7, histone deacetylase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HD7, HD7A, HDAC7A
  • Links
    NCBI Gene ID: 51564
    neXtProt AC: NX_Q8WUI4
    UniProt: Q8WUI4

  • Chr Location
    12q13.11; chr12:47782710-47820612 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    48
  • Tissues
    14
  • cDNA Data
    102
  • Literature Summary
    14
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029597 VEGA Gene Model | MGI Sequence Detail 51839 C57BL/6J ±  kb
transcript OTTMUST00000073417 VEGA | MGI Sequence Detail 4113 Not Applicable  
polypeptide OTTMUSP00000037987 VEGA | MGI Sequence Detail 953 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    301 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    cDNA 102
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443780
References
more
  • Summaries
    All 74
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 13
    Phenotypes 26
  • Earliest
    J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory