Hdac7 MGI Mouse Gene Detail - MGI:1891835

Hdac7 Gene Detail

Symbol

Hdac7
Name

histone deacetylase 7
Synonyms

5830434K02Rik, Hdac7a

Feature Type

protein coding gene
IDs

MGI:1891835
NCBI Gene: 56233
Gene Overview

MyGene.info: HDAC7

Sequence Map

Chr15:97792664-97844502 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

51839 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 53.79 cM, cytoband F2
Mapping Data

2 experiments

Human Ortholog

HDAC7, histone deacetylase 7

Vertebrate Orthologs

10

Human Ortholog

HDAC7, histone deacetylase 7
Orthology source: HomoloGene, HGNC
Synonyms

HD7, HD7A, HDAC7A
Links

HGNC:14067

NCBI Gene ID: 51564

neXtProt AC: NX_Q8WUI4
Chr Location

12q13.1; chr12:47782722-47820612 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 9124
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: HDAC7
Protein SuperFamily

histone deacetylase class II, eukaryotic type
Gene Tree

Hdac7

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Hdac7
Incidental Mutations

Mutagenetix , APF

Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects.

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All GO Annotations

38
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

48
Tissues

14
cDNA Data

102
Literature Summary

14

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA HDAC7

Xenbase hdac7

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Hdac7 interacts with 184 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

117
RefSeq

32
UniProt

10
CCDS

CCDS37188.1, CCDS57001.1, CCDS57002.1, CCDS57003.1, CCDS57004.1, CCDS57005.1, CCDS57006.1, CCDS57007.1
UniGene

384027

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029597	VEGA Gene Model \| MGI Sequence Detail	51839	C57BL/6J	± kb
transcript	OTTMUST00000073417	VEGA \| MGI Sequence Detail	4113	Not Applicable
polypeptide	OTTMUSP00000037987	VEGA \| MGI Sequence Detail	953	Not Applicable

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SNPs within 2kb

301 from dbSNP Build 142

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UniProt

10 Sequences
Protein Ontology

PR:000008486 histone deacetylase 7
EC

3.5.1.98
InterPro Domains

IPR023801 Histone deacetylase domain

IPR000286 Histone deacetylase superfamily

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All nucleic 104

cDNA 102

Primer pair 2

Microarray probesets 4

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MGI:2443780

Summaries

All 50

Developmental Gene Expression 14

Diseases 1

Gene Ontology 9

Phenotypes 25
Earliest

J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
Latest

J:218396 Bradley EW, et al., Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and beta-catenin activity during endochondral ossification. J Biol Chem. 2015 Jan 2;290(1):118-26

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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