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Nupr1
Gene Detail
 Symbol
Name
ID
Nupr1
nuclear protein transcription regulator 1
MGI:1891834
Synonyms 2310032H04Rik, Com1, p8
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.21 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:126623249-126630861 bp, - strand
From VEGA annotation of GRCm38

  7613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8229  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 cattle; 1 dog

Gene Tree: Nupr1

Human
homologs
Human Homolog NUPR1, nuclear protein, transcriptional regulator, 1
NCBI Gene ID 26471
neXtProt AC  NX_O60356
Human Synonyms  COM1, P8
Human Chr (Location)  16p11.2; chr16:28537341-28539174 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
 
MEFs from homozygous null mice display increased cell proliferation and reduced sensitivity to induced apoptosis.
 
Interactions
Nupr1 interacts with 38 markers (Mir25, Mir92-2, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process acute inflammatory response, cell growth, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (80)    Tissues (30)    Images (22)
Theiler Stages: 15, 17, 19, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 59
Northern blot 13
RT-PCR 8
cDNA source data(69)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) cDNA(69) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025271 (Evidence)
Ensembl Gene ModelENSMUSG00000030717 (Evidence)
Entrez Gene56312 (Evidence)
UniGene18742
DFCITC1575903, TC1607128
DoTSDT.101367426, DT.101706943
NIA Mouse Gene IndexU029253
Consensus CDS ProjectCCDS40127.1
International Mouse Knockout Project StatusNupr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025271 VEGA Gene Model | MGI Sequence Detail 7613 C57BL/6J ±  kb
transcript OTTMUST00000062207 VEGA | MGI Sequence Detail 829 Not Applicable 
polypeptide OTTMUSP00000030632 VEGA | MGI Sequence Detail 80 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018792 Nuclear phosphoprotein p8, DNA binding
Protein Ontology PR:000011529 nuclear protein 1
References (Earliest) J:64814 Vasseur S, et al., Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J. 1999 Oct 15;343 Pt 2:377-83
(Latest) J:203693 Barbosa-Sampaio HC, et al., Nupr1 deletion protects against glucose intolerance by increasing beta cell mass. Diabetologia. 2013 Nov;56(11):2477-86
All references(49)
Other
accession IDs
MGI:1916880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory