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Nupr1 Gene Detail
Summary
  • Symbol
    Nupr1
  • Name
    nuclear protein transcription regulator 1
  • Synonyms
    2310032H04Rik, Com1, p8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891834
    NCBI Gene: 56312
  • Gene Overview
    MyGene.info: NUPR1
Location & Maps
more
  • Sequence Map
    Chr7:126623249-126630861 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7613 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.21 cM, cytoband F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COM1, P8
  • Links
    NCBI Gene ID: 26471
    neXtProt AC: NX_O60356

  • Chr Location
    16p11.2; chr16:28537341-28539174 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    11
  • Targeted
    2
MEFs from homozygous null mice display increased cell proliferation and reduced sensitivity to induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025271 VEGA Gene Model | MGI Sequence Detail 7613 C57BL/6J ±  kb
transcript OTTMUST00000062207 VEGA | MGI Sequence Detail 829 Not Applicable  
polypeptide OTTMUSP00000030632 VEGA | MGI Sequence Detail 80 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011529 nuclear protein 1
  • InterPro Domains
    IPR018792 Nuclear protein 1-like
Molecular
Reagents
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  • All nucleic 72
    cDNA 69
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1916880
References
more
  • Summaries
    All 50
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:64814 Vasseur S, et al., Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J. 1999 Oct 15;343 Pt 2:377-83
  • Latest
    J:230281 Weis S, et al., P8 deficiency increases cellular ROS and induces HO-1. Arch Biochem Biophys. 2015 Jan 1;565:89-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory