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Nupr1 Gene Detail
Summary
  • Symbol
    Nupr1
  • Name
    nuclear protein transcription regulator 1
  • Synonyms
    2310032H04Rik, Com1, p8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891834
    NCBI Gene: 56312
  • Gene Overview
    MyGene.info: NUPR1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126623246-126625470 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.21 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891834
protein coding gene Chr7:126623246-126630861 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032989
protein coding gene Chr7:130907428-130914815 (-)
A/J MGP_AJ_G0032972
protein coding gene Chr7:127444332-127451650 (-)
AKR/J MGP_AKRJ_G0032904
protein coding gene Chr7:130668103-130675490 (-)
BALB/cJ MGP_BALBcJ_G0032977
protein coding gene Chr7:127101613-127109000 (-)
C3H/HeJ MGP_C3HHeJ_G0032687
protein coding gene Chr7:130605194-130612732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033483
protein coding gene Chr7:135996636-136005683 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030455
protein coding gene Chr7:128630784-128638536 (-)
CAST/EiJ MGP_CASTEiJ_G0032015
protein coding gene Chr7:122392128-122399533 (-)
CBA/J MGP_CBAJ_G0032660
protein coding gene Chr7:140570390-140580339 (-)
DBA/2J MGP_DBA2J_G0032812
protein coding gene Chr7:125419866-125427438 (-)
FVB/NJ MGP_FVBNJ_G0032765
protein coding gene Chr7:125270061-125277448 (-)
LP/J MGP_LPJ_G0032906
protein coding gene Chr7:132372821-132380208 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032797
protein coding gene Chr7:141758712-141766099 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033502
protein coding gene Chr7:129683255-129690573 (-)
PWK/PhJ MGP_PWKPhJ_G0031723
protein coding gene Chr7:118408308-118415931 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031569
protein coding gene Chr7:116516127-116523501 (-)
WSB/EiJ MGP_WSBEiJ_G0032128
protein coding gene Chr7:130658831-130666216 (-)



Homology
more
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COM1, P8
  • Links
    NCBI Gene ID: 26471
    neXtProt AC: NX_O60356
    UniProt: O60356

  • Chr Location
    16p11.2; chr16:28537341-28539174 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nupr1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
MEFs from homozygous null mice display increased cell proliferation and reduced sensitivity to induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56312 NCBI Gene Model | MGI Sequence Detail 2225 C57BL/6J ±  kb
    transcript NM_019738 RefSeq | MGI Sequence Detail 639 Not Specified  
    polypeptide Q9WTK0 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 70
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916880
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:64814 Vasseur S, et al., Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J. 1999 Oct 15;343 Pt 2:377-83
    • Latest
      J:264428 Hollenbach M, et al., p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet. PLoS One. 2018;13(7):e0201159

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory