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Patz1 Gene Detail
Summary
  • Symbol
    Patz1
  • Name
    POZ (BTB) and AT hook containing zinc finger 1
  • Synonyms
    8430401L15Rik, MAZR, POZ-AT hook-zinc finger protein, Zfp278
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891832
    NCBI Gene: 56218
  • Gene Overview
    MyGene.info: PATZ1
Location & Maps
more
  • Sequence Map
    Chr11:3288874-3309083 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20210 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PATZ1, POZ/BTB and AT hook containing zinc finger 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PATZ1, POZ/BTB and AT hook containing zinc finger 1
    Orthology source: HomoloGene
  • Synonyms
    dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG
  • Links
    NCBI Gene ID: 23598
    neXtProt AC: NX_Q9HBE1

  • Chr Location
    22q12.2; chr22:31325804-31346263 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    61
  • Gene trapped
    53
  • Targeted
    8
  • Incidental Mutations
Mice homozygous for a null allele exhibit some embryonic and fetal lethality, exencephaly, nervous system defects, outflow defects, transposition of great arteries, postnatal growth retardation and male and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000758 VEGA Gene Model | MGI Sequence Detail 20210 C57BL/6J ±  kb
transcript OTTMUST00000001447 VEGA | MGI Sequence Detail 3702 Not Applicable  
polypeptide OTTMUSP00000000690 VEGA | MGI Sequence Detail 687 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1921776, MGI:2144162
References
more
  • Summaries
    All 46
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:64686 Kobayashi A, et al., A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol Cell Biol. 2000 Mar;20(5):1733-46
  • Latest
    J:224414 Keskin N, et al., PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Mol Cell Biol. 2015 May;35(10):1741-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory