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Sfn
Gene Detail
Symbol

Name
ID
Sfn
stratifin
MGI:1891831
Synonyms
14-3-3 sigma, Er, MME1, Ywhas
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.25 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:133600556-133602168 bp, - strand
From VEGA annotation of GRCm38

  1613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: 14-3-3 protein
Gene Tree: Sfn

Human
homologs
Human Homolog SFN, stratifin
NCBI Gene ID 2810
neXtProt AC  NX_P31947
Human Synonyms  YWHAS
Human Chr (Location)  1p36.11; chr1:26863142-26864456 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Targeted(4)
 
Nullizygous mice show impaired B-cell homeostasis, BCR signaling, and T cell-independent B-cell responses. Homozygous hypomorphs show altered mammary epithelial morphology. Spontaneous mutants die at birth from respiratory stress with severe anomalies in skin, limbs, tails, face and oral cavity.
 
Phenotype Images(12)
Interactions
Sfn interacts with 53 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process establishment of skin barrier, intrinsic apoptotic signaling pathway in response to DNA damage, ...
Component cytoplasm, extracellular region, ...
Function phosphoprotein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (122)    Tissues (114)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
Northern blot 3
Western blot 6
cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(107) Genomic(1) cDNA(104) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011150 (Evidence)
Ensembl Gene ModelENSMUSG00000047281 (Evidence)
Entrez Gene55948 (Evidence)
UniGene44482
DFCITC1695351, TC1579442
DoTSDT.94348837, DT.536979
NIA Mouse Gene IndexU048880, U025621
Consensus CDS ProjectCCDS18754.1
International Mouse Knockout Project StatusSfn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011150 VEGA Gene Model | MGI Sequence Detail 1613 C57BL/6J ±  kb
transcript OTTMUST00000026117 VEGA | MGI Sequence Detail 1613 Not Applicable 
polypeptide OTTMUSP00000011953 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000014742 14-3-3 protein sigma
References
(Earliest) J:29020 Hunsicker, Repeated epilation, Er. Mouse News Lett. 1960;23:58-9
(Latest) J:203995 Lee S, et al., Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev Biol. 2013 Nov 15;383(2):201-13
All references(80)
Other
accession IDs
MGD-MRK-9568, MGI:95409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory