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Pkp3
Gene Detail
Symbol

Name
ID
Pkp3
plakophilin 3
MGI:1891830
Synonyms
2310056L12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.34 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141078218-141090510 bp, + strand
From VEGA annotation of GRCm38

  12293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Pkp3

Human
homologs
Human Homolog PKP3, plakophilin 3
NCBI Gene ID 11187
neXtProt AC  NX_Q9Y446
Human Chr (Location)  11p15; chr11:392614-404908 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit retarded hair growth, epidermal thickening and abnormal hair follicles that lead to secondary alopecia and acute dermatitis.
 
Interactions
Pkp3 interacts with 51 markers (Mir15a, Mir15b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, desmosome assembly, ...
Component cell junction, desmosome, ...
Function cell adhesion molecule binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(95)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000028871 (Evidence)
Ensembl Gene ModelENSMUSG00000054065 (Evidence)
Entrez Gene56460 (Evidence)
UniGene350037
DFCITC1576652
DoTSDT.101370922, DT.533225, DT.94353405
NIA Mouse Gene IndexU008945
Consensus CDS ProjectCCDS21999.1, CCDS52437.1
International Mouse Knockout Project StatusPkp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028871 VEGA Gene Model | MGI Sequence Detail 12293 C57BL/6J ±  kb
transcript OTTMUST00000071509 VEGA | MGI Sequence Detail 2919 Not Applicable 
polypeptide OTTMUSP00000036647 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000012792 plakophilin-3
References
(Earliest) J:64912 Bonne S, et al., Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J Cell Sci. 1999 Jul;112(Pt 14):2265-76
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(38)
Other
accession IDs
MGI:1917432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory