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Pkp3
Gene Detail
Symbol

Name
ID
Pkp3
plakophilin 3
MGI:1891830
Synonyms
2310056L12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.34 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141078218-141090510 bp, + strand
From VEGA annotation of GRCm38

  12293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PKP3
Gene Tree: Pkp3

Human
homologs
PKP3, plakophilin 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11187
neXtProt AC: NX_Q9Y446

Human Chr (Location): 11p15; chr11:392599-404908 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit retarded hair growth, epidermal thickening and abnormal hair follicles that lead to secondary alopecia and acute dermatitis.
 
Interactions
Pkp3 interacts with 51 markers (Mir15a, Mir15b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, desmosome assembly, ...
Component cell junction, desmosome, ...
Function alpha-catenin binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(95)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pkp3 ; ZFIN pkp3a    NEW 
Molecular
reagents
All nucleic(95) cDNA(95)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000028871 (Evidence)
Ensembl Gene Model ENSMUSG00000054065 (Evidence)
Entrez Gene 56460 (Evidence)
UniGene 350037
DFCI TC1576652
DoTS DT.533225, DT.101370922, DT.94353405
NIA Mouse Gene Index U008945
Consensus CDS Project CCDS21999.1, CCDS52437.1
International Mouse Phenotyping Consortium Status Pkp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028871 VEGA Gene Model | MGI Sequence Detail 12293 C57BL/6J ±  kb
transcript OTTMUST00000071509 VEGA | MGI Sequence Detail 2919 Not Applicable 
polypeptide OTTMUSP00000036647 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000012792 plakophilin-3
References
(Earliest) J:64912 Bonne S, et al., Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J Cell Sci. 1999 Jul;112(Pt 14):2265-76
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(37)
Other
accession IDs
MGI:1917432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory