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Pkp3 Gene Detail
Summary
  • Symbol
    Pkp3
  • Name
    plakophilin 3
  • Synonyms
    2310056L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891830
    NCBI Gene: 56460
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140658202-140670424 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.34 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891830
 protein coding gene Chr7:140658131-140670424 (+)
129S1/SvImJ ENSMUSG00200044577
 protein coding gene Chr7:127224830-127227238 (+)
129S1/SvImJ ENSMUSGG00200054467
 protein coding gene Chr7:127227392-127228171 (+)
A/J ENSMUSGG00195055467
 protein coding gene Chr7:131709823-131710602 (+)
A/J ENSMUSG00195039380
 protein coding gene Chr7:131707261-131709669 (+)
AKR/J ENSMUSGG00220054909
 protein coding gene Chr7:125191618-125192397 (+)
AKR/J ENSMUSG00220026556
 protein coding gene Chr7:125189052-125191464 (+)
BALB/cJ ENSMUSG00180034549
 protein coding gene Chr7:128399452-128401860 (+)
BALB/cJ ENSMUSGG00180055549
 protein coding gene Chr7:128402014-128402793 (+)
C3H/HeJ ENSMUSG00175036251
 protein coding gene Chr7:129127735-129130143 (+)
C3H/HeJ ENSMUSGG00175055071
 protein coding gene Chr7:129130297-129131076 (+)
C57BL/6NJ ENSMUSGG00215055713
 protein coding gene Chr7:128396861-128397640 (+)
C57BL/6NJ ENSMUSG00215044807
 protein coding gene Chr7:128394299-128396707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030676
 protein coding gene Chr7:143278646-143290343 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054598
 protein coding gene Chr7:128888333-128889112 (+)
CBA/J ENSMUSG00210027677
 protein coding gene Chr7:128885771-128888179 (+)
DBA/2J ENSMUSGG00185057911
 protein coding gene Chr7:133166851-133167630 (+)
DBA/2J ENSMUSG00185015982
 protein coding gene Chr7:133164289-133166697 (+)
FVB/NJ ENSMUSGG00205054133
 protein coding gene Chr7:128809135-128809914 (+)
FVB/NJ ENSMUSG00205038208
 protein coding gene Chr7:128806573-128808981 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055357
 protein coding gene Chr7:139330324-139331103 (+)
LP/J ENSMUSG00230037693
 protein coding gene Chr7:139327762-139330170 (+)
NOD/ShiLtJ ENSMUSGG00190055036
 protein coding gene Chr7:128995746-128996525 (+)
NOD/ShiLtJ ENSMUSG00190018447
 protein coding gene Chr7:128993184-128995592 (+)
NZO/HlLtJ ENSMUSGG00225055694
 protein coding gene Chr7:137539557-137540336 (+)
NZO/HlLtJ ENSMUSG00225051676
 protein coding gene Chr7:137536995-137539403 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010039920
 protein coding gene Chr7:128810867-128822781 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PKP3, plakophilin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKP3, plakophilin 3
  • Links
    NCBI Gene ID: 11187
    UniProt: Q9Y446

  • Chr Location
    11p15.5; chr11:392596-404908 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit retarded hair growth, epidermal thickening and abnormal hair follicles that lead to secondary alopecia and acute dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    7
  • cDNA Data
    97
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56460 NCBI Gene Model | MGI Sequence Detail 12223 C57BL/6J ±  kb
    transcript NM_019762 RefSeq | MGI Sequence Detail 2857 C57BL/6  
    polypeptide Q9QY23 UniProt | EBI | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 97
      Primer pair 2
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917432
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 9
      Gene Ontology 19
      Phenotypes 13
    • Earliest
      J:64912 Bonne S, et al., Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J Cell Sci. 1999 Jul;112(Pt 14):2265-76
    • Latest
      J:374927 Li X, et al., Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas. Cell Rep. 2025 Oct 29;44(11):116487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory