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Rbx1
Gene Detail
Symbol

Name
ID
Rbx1
ring-box 1
MGI:1891829
Synonyms
1500002P15Rik, ROC1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:81466316-81476369 bp, + strand
From NCBI annotation of GRCm38

  10054 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134530  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle

Protein SuperFamily: RING-box protein/anaphase-promoting complex, subunit 11
Gene Tree: Rbx1

Mutations,
alleles, and
phenotypes
All mutations/alleles(90) : Gene trapped(87) Radiation induced(1) Targeted(2)
Genomic Mutations involving Rbx1 (1)
 
Mice homozygous for a null mutation display embryonic lethality before somite formation with reduced embryo size and decreased cell proliferation. Embryonic fibroblasts from heterozygous mice display decreased cell proliferation and cell cycle abnormalities.
 
Interactions
Rbx1 interacts with 119 markers (Mir10a, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (30)    Tissues (16)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 24
cDNA source data(169)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(169) cDNA(169)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000022400 (Evidence)
Entrez Gene56438 (Evidence)
UniGene29405
DFCITC1717328, TC1571967
DoTSDT.99869415, DT.55204134, DT.110562475, DT.101370586, DT.495786, DT.103566367, DT.101318407, DT.101370242, DT.101358146
NIA Mouse Gene IndexU052548, U016464
EC6.3.2.-
PDB4A0K, 4A0C, 4A0L
Consensus CDS ProjectCCDS49676.1
International Mouse Knockout Project StatusRbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56438 NCBI Gene Model | MGI Sequence Detail 10054 C57BL/6J ±  kb
transcript NM_019712 RefSeq | MGI Sequence Detail 1655 C57BL/6 
polypeptide P62878 UniProt | EBI | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR024766 Zinc finger, RING-H2-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000000043 E3 ubiquitin-protein ligase RBX1
Graphical View of Protein Domain Structure
References
(Earliest) J:64811 Kamura T, et al., Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase [see comments]. Science. 1999 Apr 23;284(5414):657-61
(Latest) J:205551 Simo S, et al., Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
All references(51)
Other
accession IDs
MGI:1913478, MGI:2145915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory