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Acin1 Gene Detail
Summary
  • Symbol
    Acin1
  • Name
    apoptotic chromatin condensation inducer 1
  • Synonyms
    2610036I19Rik, 2610510L13Rik, Acinus, mKIAA0670
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891824
    NCBI Gene: 56215
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54879618-54924388 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1949 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891824
 protein coding gene Chr14:54879618-54924422 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021321
 protein coding gene Chr14:48608258-48656482 (-)
A/J MGP_AJ_G0021280
 protein coding gene Chr14:47654675-47700016 (-)
AKR/J MGP_AKRJ_G0021256
 protein coding gene Chr14:49379620-49424218 (-)
BALB/cJ MGP_BALBcJ_G0021284
 protein coding gene Chr14:47629143-47674773 (-)
C3H/HeJ MGP_C3HHeJ_G0021064
 protein coding gene Chr14:49071675-49122544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021722
 protein coding gene Chr14:51070786-51120345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019267
 protein coding gene Chr14:46070413-46114823 (-)
CAST/EiJ MGP_CASTEiJ_G0020583
 protein coding gene Chr14:45314952-45363976 (-)
CBA/J MGP_CBAJ_G0021031
 protein coding gene Chr14:52580451-52646382 (-)
DBA/2J MGP_DBA2J_G0021152
 protein coding gene Chr14:47394231-47439344 (-)
FVB/NJ MGP_FVBNJ_G0021134
 protein coding gene Chr14:46848600-46893270 (-)
LP/J MGP_LPJ_G0021226
 protein coding gene Chr14:49611749-49656422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021158
 protein coding gene Chr14:52002514-52053460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021749
 protein coding gene Chr14:48565920-48611782 (-)
PWK/PhJ MGP_PWKPhJ_G0020329
 protein coding gene Chr14:43925033-43972331 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020157
 protein coding gene Chr14:44548448-44592781 (-)
WSB/EiJ MGP_WSBEiJ_G0020636
 protein coding gene Chr14:48853004-48900047 (-)



Homology
more
  • Human Ortholog
    ACIN1, apoptotic chromatin condensation inducer 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACIN1, apoptotic chromatin condensation inducer 1
  • Synonyms
    ACINUS, ACN, fSAP152
  • Links
    NCBI Gene ID: 22985
    UniProt: Q9UKV3

  • Chr Location
    14q11.2; chr14:23058564-23095614 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    47
  • cDNA Data
    193
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022185 Ensembl Gene Model | MGI Sequence Detail 44771 C57BL/6J ±  kb
transcript ENSMUST00000022793 Ensembl | MGI Sequence Detail 4735 Not Applicable  
polypeptide ENSMUSP00000022793 Ensembl | MGI Sequence Detail 1338 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000003627 apoptotic chromatin condensation inducer in the nucleus
    (term hierarchy)
  • InterPro Domains
    IPR032552 Acin1, RNSP1-SAP18 binding (RSB) motif
    IPR034257 Acinus, RNA recognition motif
    IPR052793 Exon junction complex-associated protein
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR003034 SAP domain
    IPR036361 SAP domain superfamily
  • GlyGen
    Q9JIX8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 199
    cDNA 194
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913562, MGI:1919776, MGI:2145862
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:64695 Sahara S, et al., Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation [see comments]. Nature. 1999 Sep 9;401(6749):168-73
  • Latest
    J:365237 Aoto M, et al., The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis. Sci Rep. 2025;15(1):14017
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory