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Acin1 Gene Detail
Summary
  • Symbol
    Acin1
  • Name
    apoptotic chromatin condensation inducer 1
  • Synonyms
    2610036I19Rik, 2610510L13Rik, Acinus, mKIAA0670
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891824
    NCBI Gene: 56215
  • Gene Overview
    MyGene.info: ACIN1
Location & Maps
more
  • Sequence Map
    Chr14:54642161-54686931 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      44771 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.87 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACIN1, apoptotic chromatin condensation inducer 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACIN1, apoptotic chromatin condensation inducer 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACINUS, ACN, fSAP152
  • Links
    NCBI Gene ID: 22985
    neXtProt AC: NX_Q9UKV3

  • Chr Location
    14q11.2; chr14:23058564-23095614 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    1
  • Gene trapped
    60
  • Targeted
    2
  • Genomic Mutations
    1 involving Acin1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    47
  • Tissues
    44
  • cDNA Data
    192
  • Literature Summary
    4
  • Other Mouse Links
    GEO
  • Other Vertebrate Links
    Xenbase acin1
    ZFIN acin1a
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033084 VEGA Gene Model | MGI Sequence Detail 44771 C57BL/6J ±  kb
transcript OTTMUST00000082640 VEGA | MGI Sequence Detail 4735 Not Applicable  
polypeptide OTTMUSP00000044319 VEGA | MGI Sequence Detail 1338 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    425 from dbSNP Build 142
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000003627 apoptotic chromatin condensation inducer in the nucleus
  • InterPro Domains
    IPR032552 Acin1, RNSP1-SAP18 binding (RSB) motif
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR003034 SAP domain
Molecular
Reagents
less
  • All nucleic 195
    cDNA 193
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913562, MGI:1919776, MGI:2145862
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:64695 Sahara S, et al., Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation [see comments]. Nature. 1999 Sep 9;401(6749):168-73
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory