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Camkk1
Gene Detail
Symbol

Name
ID
Camkk1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
MGI:1891766
Synonyms
CaMKKalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:73019008-73042073 bp, + strand
From VEGA annotation of GRCm38

  23066 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CAMKK1
Gene Tree: Camkk1

Human
homologs
CAMKK1, calcium/calmodulin-dependent protein kinase kinase 1, alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84254
neXtProt AC: NX_Q8N5S9

Human Synonyms: CAMKKA

Human Chr (Location): 17p13.2; chr17:3860315-3894891 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Camkk1 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele are viable, fertile and grossly normal but exhibit context fear deficits during both conditioning and long-term follow-up testing.
 
Interactions
Camkk1 interacts with 226 markers (Mir20a, Mir23b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process activation of protein kinase activity, phosphorylation, ...
Component cytoplasm, nucleus
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (40)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase camkk1    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006121 (Evidence)
Ensembl Gene Model ENSMUSG00000020785 (Evidence)
Entrez Gene 55984 (Evidence)
UniGene 9998
DFCI TC1584411
DoTS DT.55237400, DT.97364967
NIA Mouse Gene Index U012890
EC 2.7.11.17
Consensus CDS Project CCDS24993.1
International Mouse Phenotyping Consortium Status Camkk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006121 VEGA Gene Model | MGI Sequence Detail 23066 C57BL/6J ±  kb
transcript OTTMUST00000013839 VEGA | MGI Sequence Detail 3424 Not Applicable 
polypeptide OTTMUSP00000006419 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004994 calcium/calmodulin-dependent protein kinase kinase 1
References
(Earliest) J:64824 Lawson ND, et al., Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation. Exp Hematol. 1999 Nov;27(11):1682-90
(Latest) J:215561 Ferey JL, et al., Constitutive activation of CaMKKalpha signaling is sufficient but not necessary for mTORC1 activation and growth in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E686-94
All references(36)
Other
accession IDs
MGI:2144288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory