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Gps2
Gene Detail
 Symbol
Name
ID
Gps2
G protein pathway suppressor 2
MGI:1891751
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69913888-69916591 bp, + strand
From VEGA annotation of GRCm38

  2704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49599  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gps2

Human
homologs
Human Homolog GPS2, G protein pathway suppressor 2
NCBI Gene ID 2874
neXtProt AC  NX_Q13227
Human Synonyms  AMF-1
Human Chr (Location)  17p13; chr17:7312659-7315339 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Gene trapped(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gps2 interacts with 26 markers (Mir29b-1, Mir133a-1, Mir133a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process negative regulation of JNK cascade, negative regulation of transcription from RNA polymerase II promoter
Component nucleus, transcriptional repressor complex
Function protein binding, transcription corepressor activity
External Resources: FuncBase
Expression
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(79)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006026 (Evidence)
Ensembl Gene ModelENSMUSG00000023170 (Evidence)
Entrez Gene56310 (Evidence)
UniGene477738
DFCITC1580898, TC1754638
DoTSDT.530625, DT.94248276
NIA Mouse Gene IndexU157216
Consensus CDS ProjectCCDS24922.1
International Mouse Knockout Project StatusGps2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006026 VEGA Gene Model | MGI Sequence Detail 2704 C57BL/6J ±  kb
transcript OTTMUST00000037515 VEGA | MGI Sequence Detail 1311 Not Applicable 
polypeptide OTTMUSP00000016813 VEGA | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026094 G protein pathway suppressor 2
Protein Ontology PR:000008203 G protein pathway suppressor 2
References (Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:135288 Zhang D, et al., G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. J Biol Chem. 2008 Mar 28;283(13):8580-90
All references(27)
Other
accession IDs
MGI:2144211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory