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Gps2 Gene Detail
Summary
  • Symbol
    Gps2
  • Name
    G protein pathway suppressor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891751
    NCBI Gene: 56310
  • Gene Overview
    MyGene.info: GPS2
Location & Maps
more
  • Sequence Map
    Chr11:69913888-69916591 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2704 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GPS2, G protein pathway suppressor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPS2, G protein pathway suppressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMF-1
  • Links
    NCBI Gene ID: 2874
    neXtProt AC: NX_Q13227

  • Chr Location
    17p13.1; chr17:7312659-7315339 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 49599
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Gps2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006026 VEGA Gene Model | MGI Sequence Detail 2704 C57BL/6J ±  kb
transcript OTTMUST00000037515 VEGA | MGI Sequence Detail 1311 Not Applicable  
polypeptide OTTMUSP00000016813 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR026094 G protein pathway suppressor 2
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144211
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:219351 Guo C, et al., The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2. J Biol Chem. 2015 Feb 6;290(6):3666-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory