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Wrap73 Gene Detail
Summary
  • Symbol
    Wrap73
  • Name
    WD repeat containing, antisense to Trp73
  • Synonyms
    2610044M17Rik, 5330425N03Rik, DD57, Wdr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891749
    NCBI Gene: 59002
  • Gene Overview
    MyGene.info: WRAP73
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154142356-154156818 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.86 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891749
protein coding gene Chr4:154142356-154167420 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029192
protein coding gene Chr4:158390728-158420843 (+)
A/J MGP_AJ_G0029157
protein coding gene Chr4:151746369-151771314 (+)
AKR/J MGP_AKRJ_G0029105
protein coding gene Chr4:155887756-155915080 (+)
BALB/cJ MGP_BALBcJ_G0029173
protein coding gene Chr4:152213106-152240293 (+)
C3H/HeJ MGP_C3HHeJ_G0028894
protein coding gene Chr4:156420324-156450342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029622
protein coding gene Chr4:164057137-164084587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026868
protein coding gene Chr4:144044340-144074121 (+)
CAST/EiJ MGP_CASTEiJ_G0028307
protein coding gene Chr4:153819868-153848992 (+)
CBA/J MGP_CBAJ_G0028856
protein coding gene Chr4:168980789-169012088 (+)
DBA/2J MGP_DBA2J_G0029005
protein coding gene Chr4:151773100-151797777 (+)
FVB/NJ MGP_FVBNJ_G0028969
protein coding gene Chr4:150975957-151000768 (+)
LP/J MGP_LPJ_G0029095
protein coding gene Chr4:158300933-158330121 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028996
protein coding gene Chr4:171896640-171927338 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029654
protein coding gene Chr4:156451413-156477039 (+)
PWK/PhJ MGP_PWKPhJ_G0028027
protein coding gene Chr4:147855677-147881382 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027861
protein coding gene Chr4:150744004-150776233 (+)
WSB/EiJ MGP_WSBEiJ_G0028387
protein coding gene Chr4:156617863-156647789 (+)



Homology
more
  • Human Ortholog
    WRAP73, WD repeat containing, antisense to TP73
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WRAP73, WD repeat containing, antisense to TP73
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WDR8
  • Links
    NCBI Gene ID: 49856
    neXtProt AC: NX_Q9P2S5
    UniProt: Q9P2S5

  • Chr Location
    1p36.32; chr1:3630767-3650107 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9857
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WRAP73
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 59002 NCBI Gene Model | MGI Sequence Detail 14463 C57BL/6J ±  kb
transcript NM_021499 RefSeq | MGI Sequence Detail 1600 C57BL/6  
polypeptide Q9JM98 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029874 WD repeat-containing protein WRAP73
  • InterPro Domains
    IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
    IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913832, MGI:1924405
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233615 Kurtulmus B, et al., WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. J Cell Sci. 2016 Feb 1;129(3):621-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory