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Maea Gene Detail
Summary
  • Symbol
    Maea
  • Name
    macrophage erythroblast attacher
  • Synonyms
    1110030D19Rik, Gid9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891748
    NCBI Gene: 59003
Location & Maps
more
  • Sequence Map
    Chr5:33335509-33373296 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.55 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAEA, macrophage erythroblast attacher
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAEA, macrophage erythroblast attacher
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EMLP, EMP, GID9, HLC-10, PIG5
  • Links
    NCBI Gene ID: 10296
    neXtProt AC: NX_Q7L5Y9

  • Chr Location
    4p16.3; chr4:1289851-1340148 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4298
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MAEA
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    8 involving Maea
  • Incidental Mutations
Mice homozygous for a gene trapped allele die perinatally displaying reduced fetal size, pallor, reduced numbers of erythroblastic islands, defects in terminal erythroid maturation, and severely impaired terminal differentiation of fetal liver macrophages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055361 VEGA Gene Model | MGI Sequence Detail 37788 C57BL/6J ±  kb
transcript OTTMUST00000137068 VEGA | MGI Sequence Detail 2193 Not Applicable  
polypeptide OTTMUSP00000072240 VEGA | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    226 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 173
    cDNA 173

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915075
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 31
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196696 Zou Z, et al., The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 Apr 18;121(16):3228-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory