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Dact1
Gene Detail
 Symbol
Name
ID
Dact1
dapper homolog 1, antagonist of beta-catenin (xenopus)
MGI:1891740
Synonyms Dapper1, Frd1, Frodo, Frodo1, THYEX3
Feature Type protein coding gene
Genetic Map
Chromosome 12
29.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:71309884-71320107 bp, + strand
From VEGA annotation of GRCm38

  10224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dact1

Human
homologs
Human Homolog DACT1, dishevelled-binding antagonist of beta-catenin 1
NCBI Gene ID 51339
neXtProt AC  NX_Q9NYF0
Human Synonyms  DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3
Human Chr (Location)  14q23.1; chr14:58634068-58648321 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal embryogenesis, blind-ended colons, and abnormal renal/urinary system.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process dendrite morphogenesis, embryonic hindgut morphogenesis, ...
Component beta-catenin destruction complex, cell junction, ...
Function beta-catenin binding, delta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (448)    Tissues (214)    Images (89)
Theiler Stages: 6, 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 405
Northern blot 39
RT-PCR 4
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033610 (Evidence)
Ensembl Gene ModelENSMUSG00000044548 (Evidence)
Entrez Gene59036 (Evidence)
Consensus CDS ProjectCCDS25963.1, CCDS49083.1
International Mouse Knockout Project StatusDact1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033610 VEGA Gene Model | MGI Sequence Detail 10224 C57BL/6J ±  kb
transcript OTTMUST00000084680 VEGA | MGI Sequence Detail 2448 Not Applicable 
polypeptide OTTMUSP00000045666 VEGA | MGI Sequence Detail 815 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024848 Dact1
InterPro IPR024843 Dapper
Protein Ontology PR:000006263 dapper homolog 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203731 Arguello A, et al., Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013;8(6):e67679
All references(50)
Other
accession IDs
MGI:1913988, MGI:2144761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory