Stub1
Gene Detail

Symbol Name ID

Stub1 STIP1 homology and U-Box containing protein 1 MGI:1891731

Synonyms

0610033N24Rik, 2210017D18Rik, 2310040B03Rik, CHIP

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.93 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:25830636-25833361 bp, - strand From NCBI annotation of GRCm38   2726 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Stub1 ± 2 cM)

Protein SuperFamily: CHIP with U-box/Tetratricopeptide repeats
Gene Tree: Stub1

Human ortholog

STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase NCBI Gene ID 10273
Human Synonyms: CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1
Human Chr16:730115-732768 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mice develop normally but are susceptible to stress-induced apoptosis of multiple organs. Increased peri- and postnatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	cellular response to misfolded protein, DNA repair, ...
Component	cytoplasm, nuclear inclusion body, ...
Function	enzyme binding, heat shock protein binding, ...

External Resources: FuncBase

Expression

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000039615 (Evidence)
Entrez Gene	56424 (Evidence)
EC	6.3.2.-
PDB	2C2L, 2C2V, 3Q47, 3Q49, 3Q4A
Consensus CDS Project	CCDS28533.1
International Mouse Knockout Project Status	Stub1

Sequences

Length	Strain/Species
genomic	56424	NCBI Gene Model | MGI Sequence Detail	2726	C57BL/6J
transcript	NM_019719	RefSeq | MGI Sequence Detail	1672	C57BL/6
polypeptide	Q9WUD1	UniProt | EBI | MGI Sequence Detail	304	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
InterPro	IPR003613	U box domain
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000015784	STIP1y and U box-containing protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
(Latest) J:185347 Lim ST, et al., Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012 Jun 25;197(7):907-19
All references(50)

Other accession IDs

MGI:1913330, MGI:1916886, MGI:1917365, MGI:2147033