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Stub1
Gene Detail
 Symbol
Name
ID
Stub1
STIP1 homology and U-Box containing protein 1
MGI:1891731
Synonyms 0610033N24Rik, 2210017D18Rik, 2310040B03Rik, CHIP
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.93 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:25830636-25833361 bp, - strand
From NCBI annotation of GRCm38

  2726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: CHIP with U-box/Tetratricopeptide repeats
Gene Tree: Stub1

Human
homologs
Human Homolog STUB1, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
NCBI Gene ID 10273
neXtProt AC  NX_Q9UNE7
Human Synonyms  CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1
Human Chr (Location)  16p13.3; chr16:680115-682768 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human STUB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Radiation induced(2) Targeted(7)
Genomic Mutations involving Stub1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop normally but are susceptible to stress-induced apoptosis of multiple organs. Increased peri- and postnatal lethality.
 
Human Diseases Modeled Using Mouse Stub1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Stub1 interacts with 30 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process cellular response to DNA damage stimulus, cellular response to misfolded protein, ...
Component cytoplasm, endoplasmic reticulum, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039615 (Evidence)
Entrez Gene56424 (Evidence)
EC6.3.2.-
PDB2C2L, 2C2V, 3Q4A, 3Q47, 3Q49
Consensus CDS ProjectCCDS28533.1
International Mouse Knockout Project StatusStub1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56424 NCBI Gene Model | MGI Sequence Detail 2726 C57BL/6J ±  kb
transcript NM_019719 RefSeq | MGI Sequence Detail 1672 C57BL/6 
polypeptide Q9WUD1 UniProt | EBI | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR003613 U box domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000015784 E3 ubiquitin-protein ligase CHIP
Graphical View of Protein Domain Structure
References (Earliest) J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
(Latest) J:206229 Shi CH, et al., Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP. Hum Mol Genet. 2014 Feb 15;23(4):1013-24
All references(56)
Disease annotation references (1)
Other
accession IDs
MGI:1913330, MGI:1916886, MGI:1917365, MGI:2147033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory