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Stub1 Gene Detail
Summary
  • Symbol
    Stub1
  • Name
    STIP1 homology and U-Box containing protein 1
  • Synonyms
    0610033N24Rik, 2210017D18Rik, 2310040B03Rik, CHIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891731
    NCBI Gene: 56424
  • Gene Overview
    MyGene.info: STUB1
Location & Maps
more
  • Sequence Map
    Chr17:25830636-25833361 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2726 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.93 cM, cytoband B1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    STUB1, STIP1 homology and U-box containing protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STUB1, STIP1 homology and U-box containing protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1
  • Links
    NCBI Gene ID: 10273
    neXtProt AC: NX_Q9UNE7
    UniProt: Q9UNE7

  • Chr Location
    16p13.3; chr16:680111-682768 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human STUB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop normally but are susceptible to stress-induced apoptosis of multiple organs. Increased peri- and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56424 NCBI Gene Model | MGI Sequence Detail 2726 C57BL/6J ±  kb
transcript NM_019719 RefSeq | MGI Sequence Detail 1672 C57BL/6  
polypeptide Q9WUD1 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
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MGI:1913330, MGI:1916886, MGI:1917365, MGI:2147033
References
more
  • Summaries
    All 64
    Gene Ontology 10
    Phenotypes 22
  • Earliest
    J:64910 Ballinger CA, et al., Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol. 1999 Jun;19(6):4535-45
  • Latest
    J:236655 Seo J, et al., CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. Nat Cell Biol. 2016 Mar;18(3):291-302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory