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Hbs1l Gene Detail
Summary
  • Symbol
    Hbs1l
  • Name
    Hbs1-like (S. cerevisiae)
  • Synonyms
    2810035F15Rik, eRFS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891704
    NCBI Gene: 56422
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:21295979-21368889 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891704
protein coding gene Chr10:21295979-21368898 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017059
protein coding gene Chr10:19092622-19168417 (+)
A/J MGP_AJ_G0017037
protein coding gene Chr10:18358794-18434721 (+)
AKR/J MGP_AKRJ_G0017001
protein coding gene Chr10:18689924-18770076 (+)
BALB/cJ MGP_BALBcJ_G0016995
protein coding gene Chr10:18422907-18500898 (+)
C3H/HeJ MGP_C3HHeJ_G0016820
protein coding gene Chr10:19012531-19089292 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017457
protein coding gene Chr10:19578665-19658788 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015162
protein coding gene Chr10:17328728-17401039 (+)
CAST/EiJ MGP_CASTEiJ_G0016402
protein coding gene Chr10:18933745-19009481 (+)
CBA/J MGP_CBAJ_G0016792
protein coding gene Chr10:20481169-20570576 (+)
DBA/2J MGP_DBA2J_G0016900
protein coding gene Chr10:18238188-18312206 (+)
FVB/NJ MGP_FVBNJ_G0016895
protein coding gene Chr10:17979464-18054759 (+)
LP/J MGP_LPJ_G0016975
protein coding gene Chr10:18888695-18964045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016925
protein coding gene Chr10:20673038-20759158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017495
protein coding gene Chr10:18675038-18752912 (+)
PWK/PhJ MGP_PWKPhJ_G0016187
protein coding gene Chr10:18144642-18223727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015970
protein coding gene Chr10:18845940-18920487 (+)
WSB/EiJ MGP_WSBEiJ_G0016464
protein coding gene Chr10:18770978-18848026 (+)



Homology
more
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EF-1a, eRF3c, ERFS, HBS1, HSPC276
  • Links
    NCBI Gene ID: 10767
    neXtProt AC: NX_Q9Y450
    UniProt: Q9Y450

  • Chr Location
    6q23.3; chr6:134960378-135054898 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68525
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HBS1L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56422 NCBI Gene Model | MGI Sequence Detail 72911 C57BL/6J ±  kb
transcript NM_001145209 RefSeq | MGI Sequence Detail 5021 C57BL/6  
polypeptide Q69ZS7 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008465 HBS1-like protein
  • PDB
  • InterPro Domains
    IPR015033 HBS1-like protein, N-terminal
    IPR037189 HBS1-like protein, N-terminal domain superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
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  • All nucleic 177
    cDNA 177

    Microarray probesets 7
Other
Accession IDs
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MGI:1914465, MGI:2143582
References
more
  • Summaries
    All 38
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:261638 Liakath-Ali K, et al., An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis. Nature. 2018 Apr;556(7701):376-380

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory