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Hbs1l Gene Detail
Summary
  • Symbol
    Hbs1l
  • Name
    Hbs1-like (S. cerevisiae)
  • Synonyms
    2810035F15Rik, eRFS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891704
    NCBI Gene: 56422
Location & Maps
more
  • Sequence Map
    Chr10:21295979-21368889 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72911 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
    Orthology source: HomoloGene
  • Synonyms
    EF-1a, eRF3c, ERFS, HBS1, HSPC276
  • Links
    NCBI Gene ID: 10767
    neXtProt AC: NX_Q9Y450

  • Chr Location
    6q23.3; chr6:134960378-135054898 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68525
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HBS1L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    2
  • Genomic Mutations
    1 involving Hbs1l
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56422 NCBI Gene Model | MGI Sequence Detail 72911 C57BL/6J ±  kb
transcript NM_019702 RefSeq | MGI Sequence Detail 2793 C57BL/6  
polypeptide Q69ZS7 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    271 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008465 HBS1-like protein
  • PDB
  • InterPro Domains
    IPR015033 HBS1-like protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR009000 Translation protein, beta-barrel domain
Molecular
Reagents
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  • All nucleic 174
    cDNA 174

    Microarray probesets 7
Other
Accession IDs
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MGI:1914465, MGI:2143582
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:64917 Wallrapp C, et al., The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity. FEBS Lett. 1998 Dec 4;440(3):387-92
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory