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Gpa33 Gene Detail
Summary
  • Symbol
    Gpa33
  • Name
    glycoprotein A33 (transmembrane)
  • Synonyms
    2010310L10Rik, 2210401D16Rik, A33 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891703
    NCBI Gene: 59290
  • Gene Overview
    MyGene.info: GPA33
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:166130460-166166510 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 73.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891703
protein coding gene Chr1:166130238-166166510 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016701
protein coding gene Chr1:171652187-171694178 (+)
A/J MGP_AJ_G0016682
protein coding gene Chr1:164659208-164698118 (+)
AKR/J MGP_AKRJ_G0016648
protein coding gene Chr1:169629581-169667308 (+)
BALB/cJ MGP_BALBcJ_G0016643
protein coding gene Chr1:165135737-165176040 (+)
C3H/HeJ MGP_C3HHeJ_G0016467
protein coding gene Chr1:169852217-169891451 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017104
protein coding gene Chr1:177401278-177441924 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014813
protein coding gene Chr1:156530287-156565537 (+)
CAST/EiJ MGP_CASTEiJ_G0016047
protein coding gene Chr1:169448729-169487248 (+)
CBA/J MGP_CBAJ_G0016442
protein coding gene Chr1:183716928-183760488 (+)
DBA/2J MGP_DBA2J_G0016548
protein coding gene Chr1:163525569-163563147 (+)
FVB/NJ MGP_FVBNJ_G0016546
protein coding gene Chr1:161961669-161999031 (+)
LP/J MGP_LPJ_G0016619
protein coding gene Chr1:172732918-172773865 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016571
protein coding gene Chr1:191163811-191203791 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017140
protein coding gene Chr1:169494868-169533348 (+)
PWK/PhJ MGP_PWKPhJ_G0015833
protein coding gene Chr1:162731510-162772247 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015620
protein coding gene Chr1:168337317-168373677 (+)
WSB/EiJ MGP_WSBEiJ_G0016109
protein coding gene Chr1:169632609-169671972 (+)



Homology
more
  • Human Ortholog
    GPA33, glycoprotein A33
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GPA33, glycoprotein A33
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A33
  • Links
    NCBI Gene ID: 10223
    neXtProt AC: NX_Q99795
    UniProt: Q99795

  • Chr Location
    1q24.1; chr1:167052836-167090631 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4245
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPA33
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis and impaired oral tolerance to ovalbumin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59290 NCBI Gene Model | MGI Sequence Detail 36051 C57BL/6J ±  kb
    transcript NM_021610 RefSeq | MGI Sequence Detail 2546 C57BL/6  
    polypeptide Q9JKA5 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921497, MGI:1923785, MGI:2138634
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:64884 Johnstone CN, et al., Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000 Sep;279(3):G500-10
    • Latest
      J:234207 Malaterre J, et al., Intestinal-specific activatable Myb initiates colon tumorigenesis in mice. Oncogene. 2016 May 12;35(19):2475-84

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory