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Pnkp
Gene Detail
 Symbol
Name
ID
Pnkp
polynucleotide kinase 3'- phosphatase
MGI:1891698
Synonyms 1810009G08Rik, PNK
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.94 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44857139-44862925 bp, + strand
From VEGA annotation of GRCm38

  5787 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: bifunctional polynucleotide 3'-phosphatase/polynucleotide 5'-hydroxyl-kinase
Gene Tree: Pnkp

Human
homologs
Human Homolog PNKP, polynucleotide kinase 3'-phosphatase
NCBI Gene ID 11284
neXtProt AC  NX_Q96T60
Human Synonyms  EIEE10, MCSZ, PNK
Human Chr (Location)  19q13.3-q13.4; chr19:49861203-49867565 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PNKP
Alleles
and
phenotypes
All alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix )
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to DNA damage stimulus, dephosphorylation, ...
Component membrane, nucleus
Function ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022325 (Evidence)
Ensembl Gene ModelENSMUSG00000002963 (Evidence)
Entrez Gene59047 (Evidence)
DFCITC1575945, TC1649914, TC1697464, TC1705524
DoTSDT.101123755, DT.101394787, DT.101394788, DT.532536, DT.94157262, DT.94157279
NIA Mouse Gene IndexU042806
EC2.7.1.78, 3.1.3.32
PDB1UJX, 1YJM, 3U7E, 3U7F, 3U7G, 3U7H, 3ZVL, 3ZVM, 3ZVN, 1YJ5
Consensus CDS ProjectCCDS39945.1, CCDS71955.1
International Mouse Knockout Project StatusPnkp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022325 VEGA Gene Model | MGI Sequence Detail 5787 C57BL/6J ±  kb
transcript OTTMUST00000053209 VEGA | MGI Sequence Detail 1770 Not Applicable 
polypeptide OTTMUSP00000025292 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(19) UniProt(6)
Polymorphisms SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR023214 HAD-like domain
InterPro IPR006549 HAD-superfamily hydrolase, subfamily IIIA
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006551 Polynucleotide 3'-phosphatase
InterPro IPR013954 Polynucleotide kinase 3 phosphatase
InterPro IPR006550 Polynucleotide kinase 3-phosphatase, metazoan
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000012924 bifunctional polynucleotide phosphatase/kinase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200260 Prasad R, et al., Pol beta associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Res. 2012 Dec;40(22):11571-82
All references(39)
Other
accession IDs
MGI:1923601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory