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Pnkp
Gene Detail
Symbol

Name
ID
Pnkp
polynucleotide kinase 3'- phosphatase
MGI:1891698
Synonyms
1810009G08Rik, PNK
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.94 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44857139-44862925 bp, + strand
From VEGA annotation of GRCm38

  5787 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bifunctional polynucleotide 3'-phosphatase/polynucleotide 5'-hydroxyl-kinase
Gene Tree: Pnkp

Human
homologs
Human Homolog PNKP, polynucleotide kinase 3'-phosphatase
NCBI Gene ID 11284
neXtProt AC  NX_Q96T60
Human Synonyms  EIEE10, MCSZ, PNK
Human Chr (Location)  19q13.3-q13.4; chr19:49861203-49867565 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PNKP
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix )
Interactions
Pnkp interacts with 39 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular response to DNA damage stimulus, dephosphorylation, ...
Component membrane, mitochondrion, ...
Function ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022325 (Evidence)
Ensembl Gene ModelENSMUSG00000002963 (Evidence)
Entrez Gene59047 (Evidence)
DFCITC1649914, TC1705524, TC1697464, TC1575945
DoTSDT.94157262, DT.94157279, DT.101394787, DT.101123755, DT.101394788, DT.532536
NIA Mouse Gene IndexU042806
EC2.7.1.78, 3.1.3.32
PDB1YJ5, 3ZVL, 3U7H, 3U7G, 3U7E, 3U7F, 1UJX, 1YJM, 3ZVM, 3ZVN
Consensus CDS ProjectCCDS39945.1, CCDS71955.1
International Mouse Knockout Project StatusPnkp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022325 VEGA Gene Model | MGI Sequence Detail 5787 C57BL/6J ±  kb
transcript OTTMUST00000053208 VEGA | MGI Sequence Detail 2135 Not Applicable 
polypeptide OTTMUSP00000025291 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(19) UniProt(9)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR023214 HAD-like domain
InterPro IPR006549 HAD-superfamily hydrolase, subfamily IIIA
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006551 Polynucleotide 3'-phosphatase
InterPro IPR013954 Polynucleotide kinase 3 phosphatase
InterPro IPR006550 Polynucleotide kinase 3-phosphatase, metazoan
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000012924 bifunctional polynucleotide phosphatase/kinase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212924 Katyal S, et al., Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
All references(41)
Other
accession IDs
MGI:1923601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory