Pnkp
Gene Detail

Symbol Name ID

Pnkp polynucleotide kinase 3'- phosphatase MGI:1891698

Synonyms

1810009G08Rik, PNK

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.94 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:44857139-44862925 bp, + strand From VEGA annotation of GRCm38   5787 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: bifunctional polynucleotide 3'-phosphatase/polynucleotide 5'-hydroxyl-kinase
Gene Tree: Pnkp

Human homologs

Human Homolog		PNKP, polynucleotide kinase 3'-phosphatase
NCBI Gene ID		11284
neXtProt AC		NX_Q96T60
Human Synonyms		EIEE10, MCSZ, PNK
Human Chr (Location)		19q13.3-q13.4; chr19:50364460-50370822 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PNKP

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(5)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	dephosphorylation, DNA damage response, detection of DNA damage, ...
Component	nucleus
Function	ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ...

External Resources: FuncBase

Expression

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) cDNA(49)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022325 (Evidence)
Ensembl Gene Model	ENSMUSG00000002963 (Evidence)
Entrez Gene	59047 (Evidence)
UniGene	238254
DFCI	TC1575945, TC1649914, TC1705524
DoTS	DT.101123755, DT.101394787, DT.101394788, DT.532536, DT.94157262, DT.94157279
NIA Mouse Gene Index	U042806
EC	2.7.1.78, 3.1.3.32
PDB	1UJX, 1YJM, 3U7E, 3U7F, 3U7G, 3U7H, 3ZVL, 3ZVM, 3ZVN, 1YJ5
Consensus CDS Project	CCDS39945.1
International Mouse Knockout Project Status	Pnkp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022325	VEGA Gene Model | MGI Sequence Detail	5787	C57BL/6J
transcript	OTTMUST00000053209	VEGA | MGI Sequence Detail	1770	Not Applicable
polypeptide	OTTMUSP00000025292	VEGA | MGI Sequence Detail	522	Not Applicable

All sequences(75) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023214	HAD-like domain
InterPro	IPR006549	HAD-superfamily hydrolase, subfamily IIIA
InterPro	IPR006551	Polynucleotide 3'-phosphatase
InterPro	IPR013954	Polynucleotide kinase 3 phosphatase
InterPro	IPR015636	Polynucleotide kinase 3-phosphatase, eukaryota
InterPro	IPR006550	Polynucleotide kinase 3-phosphatase, metazoan
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000012924	bifunctional polynucleotide phosphatase/kinase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180135 Coquelle N, et al., Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21022-7
All references(37)

Other accession IDs

MGI:1923601