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Ackr2
Gene Detail
Symbol

Name
ID
Ackr2
atypical chemokine receptor 2
MGI:1891697
Synonyms
Ccbp2, chemokine decoy receptor D6, D6
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.71 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:121898464-121911064 bp, + strand
From Ensembl annotation of GRCm38

  12601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: ACKR2
Protein SuperFamily: chemokine receptor
Gene Tree: Ackr2

Human
homologs
ACKR2, atypical chemokine receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1238
neXtProt AC: NX_O00590

Human Synonyms: CCBP2, CCR10, CCR9, CMKBR9, D6, hD6

Human Chr (Location): 3p21.3; chr3:42809472-42867283 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities.
 
Interactions
Ackr2 interacts with 175 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component actin filament, endosome, ...
Function C-C chemokine binding, C-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000044534 (Evidence)
Entrez Gene 59289 (Evidence)
DFCI TC1584540
DoTS DT.94146529, DT.60104525, DT.101332001, DT.483388
NIA Mouse Gene Index U011174
Consensus CDS Project CCDS23640.1
International Mouse Phenotyping Consortium Status Ackr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044534 Ensembl Gene Model | MGI Sequence Detail 12601 C57BL/6J ±  kb
transcript ENSMUST00000050327 Ensembl | MGI Sequence Detail 2784 Not Applicable 
polypeptide ENSMUSP00000050119 Ensembl | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001277 CXC chemokine receptor 4
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001215 chemokine-binding protein 2
References
(Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:216439 Lee KM, et al., The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J. 2014 Nov 3;33(21):2564-80
All references(53)
Other
accession IDs
MGI:2143069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory