About   Help   FAQ
Ackr2
Gene Detail
 Symbol
Name
ID
Ackr2
atypical chemokine receptor 2
MGI:1891697
Synonyms Ccbp2, CCR10, CCR9, Cmkbr9, D6
Feature Type protein coding gene
Genetic Map
Chromosome 9
72.71 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:121898464-121911064 bp, + strand
From NCBI annotation of GRCm38

  12601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Ackr2

Human
homologs
Human Homolog ACKR2, atypical chemokine receptor 2
NCBI Gene ID 1238
neXtProt AC  NX_O00590
Human Synonyms  CCBP2, CCR10, CCR9, CMKBR9, D6, hD6
Human Chr (Location)  3p21.3; chr3:42809472-42867283 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component actin filament, endosome, ...
Function C-C chemokine binding, C-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 43
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000044534 (Evidence)
Entrez Gene59289 (Evidence)
DFCITC1584540
DoTSDT.101332001, DT.483388, DT.60104525, DT.94146529
NIA Mouse Gene IndexU011174
Consensus CDS ProjectCCDS23640.1
International Mouse Knockout Project StatusAckr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 59289 NCBI Gene Model | MGI Sequence Detail 12601 C57BL/6J ±  kb
transcript NM_001276719 RefSeq | MGI Sequence Detail 3012 C57BL/6 
polypeptide O08707 UniProt | EBI | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001277 CXC chemokine receptor 4
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001215 chemokine-binding protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:204855 Rot A, et al., Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor. J Immunol. 2013 Jun 15;190(12):6450-6
All references(52)
Other
accession IDs
MGI:2143069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory