Ackr2 MGI Mouse Gene Detail - MGI:1891697 - atypical chemokine receptor 2

Symbol

Ackr2
Name

atypical chemokine receptor 2
Synonyms

Ccbp2, chemokine decoy receptor D6, D6

Feature Type

protein coding gene
IDs

MGI:1891697
NCBI Gene: 59289
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:121727421-121740140 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 72.71 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

378 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891697	protein coding gene	Chr9:121727421-121740177 (+)
129S1/SvImJ	ENSMUSG00200028162	protein coding gene	Chr9:118848024-118860741 (+)
A/J	ENSMUSG00195024696	protein coding gene	Chr9:118012126-118024887 (+)
AKR/J	ENSMUSG00220018547	protein coding gene	Chr9:118466416-118479151 (+)
BALB/cJ	ENSMUSG00180023551	protein coding gene	Chr9:118549133-118561895 (+)
C3H/HeJ	ENSMUSG00175018884	protein coding gene	Chr9:118792543-118805301 (+)
C57BL/6NJ	ENSMUSG00215028603	protein coding gene	Chr9:118680392-118693111 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032835	protein coding gene	Chr9:117264646-117277705 (+)
CAST/EiJ	ENSTCUG00005016162	protein coding gene	Chr9:118400079-118412816 (+)
CBA/J	ENSMUSG00210037360	protein coding gene	Chr9:118505187-118517921 (+)
DBA/2J	ENSMUSG00185014731	protein coding gene	Chr9:118839412-118852146 (+)
FVB/NJ	ENSMUSG00205017819	protein coding gene	Chr9:118680864-118693620 (+)
JF1/MsJ	ENSUMUG00000040242	protein coding gene	Chr9:118667201-118679948 (+)
LP/J	ENSMUSG00230035545	protein coding gene	Chr9:118987140-118999859 (+)
NOD/ShiLtJ	ENSMUSG00190014600	protein coding gene	Chr9:118444342-118457061 (+)
NZO/HlLtJ	ENSMUSG00225023389	protein coding gene	Chr9:119251410-119264129 (+)
PWK/PhJ	ENSLUMG00010032002	protein coding gene	Chr9:118554863-118567613 (+)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005018929	protein coding gene	Chr9:117872889-117885641 (+)

Human Ortholog

ACKR2, atypical chemokine receptor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACKR2, atypical chemokine receptor 2
Synonyms

CCBP2, CCR10, CCR9, CMKBR9, D6, hD6
Links

HGNC:1565

NCBI Gene ID: 1238

UniProt: O00590
Chr Location

3p22.1; chr3:42804586-42887974 (+) GRCh38

MGI Vertebrate Homology

Ackr2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACKR2
Gene Tree

Ackr2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities.

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

32
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

6
UniProt

4
CCDS

CCDS23640.1

Ensembl

ENSMUSG00000044534 (Evidence)
NCBI Gene

59289

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044534	Ensembl Gene Model \| MGI Sequence Detail	12720	C57BL/6J	± kb
transcript	ENSMUST00000214340	Ensembl \| MGI Sequence Detail	3015	Not Applicable
polypeptide	ENSMUSP00000148966	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001215 atypical chemokine receptor 2

(term hierarchy)
InterPro Domains

IPR050119 C-C chemokine receptor type 1-9-like

IPR000355 Chemokine receptor family

IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

O08707 2 sites

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All nucleic 12

cDNA 11

Other 1

Microarray probesets 6

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MGI:2143069

Summaries

All 84

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 41
Earliest

J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
Latest

J:362365 Xia W, et al., The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice. Front Immunol. 2024;15:1377913

TSS for Ackr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87821	Chr9:121727475-121727489 (+)	61 bp
Tssr87822	Chr9:121727524-121727532 (+)	107 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24