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Ackr2 Gene Detail
Summary
  • Symbol
    Ackr2
  • Name
    atypical chemokine receptor 2
  • Synonyms
    Ccbp2, chemokine decoy receptor D6, D6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891697
    NCBI Gene: 59289
  • Gene Overview
    MyGene.info: ACKR2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:121898355-121911074 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12720 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.71 cM, cytoband F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ACKR2, atypical chemokine receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ACKR2, atypical chemokine receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCBP2, CCR10, CCR9, CMKBR9, D6, hD6
  • Links
    NCBI Gene ID: 1238
    neXtProt AC: NX_O00590
    UniProt: O00590

  • Chr Location
    3p22.1; chr3:42809472-42867283 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044534 Ensembl Gene Model | MGI Sequence Detail 12720 C57BL/6J ±  kb
    transcript ENSMUST00000214340 Ensembl | MGI Sequence Detail 3015 Not Applicable  
    polypeptide ENSMUSP00000148966 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      49 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143069
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 27
    • Earliest
      J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
    • Latest
      J:257944 Massara M, et al., ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity. Nat Commun. 2018 Feb 14;9(1):676

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory