Ccbp2
Gene Detail

Symbol Name ID

Ccbp2 chemokine binding protein 2 MGI:1891697

Synonyms

CCR10, CCR9, Cmkbr9, D6

Feature Type

protein coding gene

Genetic Map

Chromosome 9

72.71 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:121898464-121911064 bp, + strand From NCBI annotation of GRCm38   12601 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Ccbp2

Human homologs

Human Homolog		CCBP2, chemokine binding protein 2
NCBI Gene ID		1238
neXtProt AC		NX_O00590
Human Synonyms		CCR10, CCR9, CMKBR9, D6, hD6
Human Chr (Location)		3p21.3; chr3:42850964-42908775 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	C-C chemokine binding, C-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000044534 (Evidence)
Entrez Gene	59289 (Evidence)
UniGene	258105
DFCI	TC1584540
DoTS	DT.101332001, DT.483388, DT.60104525, DT.94146529
NIA Mouse Gene Index	U011174
Consensus CDS Project	CCDS23640.1
International Mouse Knockout Project Status	Ccbp2

Sequences

Length	Strain/Species
genomic	59289	NCBI Gene Model | MGI Sequence Detail	12601	C57BL/6J
transcript	NM_001276719	RefSeq | MGI Sequence Detail	3012	C57BL/6
polypeptide	O08707	UniProt | EBI | MGI Sequence Detail	378	Not Applicable

All sequences(27) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000355	Chemokine receptor
InterPro	IPR001277	CXC chemokine receptor, type 4
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001215	chemokine-binding protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:188610 Singh MD, et al., Elevated expression of the chemokine-scavenging receptor d6 is associated with impaired lesion development in psoriasis. Am J Pathol. 2012 Oct;181(4):1158-64
All references(50)

Other accession IDs

MGI:2143069