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Hnrnpr Gene Detail
Summary
  • Symbol
    Hnrnpr
  • Name
    heterogeneous nuclear ribonucleoprotein R
  • Synonyms
    2610003J05Rik, 2610528B01Rik, hnRNPR, Hnrpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891692
    NCBI Gene: 74326
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136038253-136086758 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.40 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    985 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891692
 protein coding gene Chr4:136038230-136086758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028965
 protein coding gene Chr4:138854710-138909899 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028948
 protein coding gene Chr4:133602767-133652064 (+)
C3H/HeJ MGP_C3HHeJ_G0028662
 protein coding gene Chr4:137060568-137110589 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029389
 protein coding gene Chr4:143797244-143881632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026660
 protein coding gene Chr4:125981729-126031658 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028627
 protein coding gene Chr4:147717001-147783201 (+)
DBA/2J MGP_DBA2J_G0028776
 protein coding gene Chr4:133359231-133408577 (+)
FVB/NJ MGP_FVBNJ_G0028743
 protein coding gene Chr4:132303786-132351795 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0028769
 protein coding gene Chr4:151948340-152003377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029427
 protein coding gene Chr4:137247051-137300264 (+)
PWK/PhJ MGP_PWKPhJ_G0027814
 protein coding gene Chr4:130137258-130188427 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0028172
 protein coding gene Chr4:137414419-137464488 (+)



Homology
more
  • Human Ortholog
    HNRNPR, heterogeneous nuclear ribonucleoprotein R
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPR, heterogeneous nuclear ribonucleoprotein R
  • Synonyms
    hnRNP-R, HNRPR, NEDDFSB
  • Links
    NCBI Gene ID: 10236
    UniProt: O43390

  • Chr Location
    1p36.12; chr1:23303771-23344358 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele in which expression of the full-length isoform is abolished while expression of the N-terminally truncated isoform is retained are viable and survive to adulthood with no overt phenotypic defects. In culture, primary motoneurons from these mice do not exhibit axonal growth defects but show increased accumulation of double strand breaks and an impaired DNA damage response upon exposure to genotoxic agents.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    47
  • cDNA Data
    22
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066037 Ensembl Gene Model | MGI Sequence Detail 48506 C57BL/6J ±  kb
transcript ENSMUST00000105850 Ensembl | MGI Sequence Detail 2683 Not Applicable  
polypeptide ENSMUSP00000101476 Ensembl | MGI Sequence Detail 632 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    14 Sequences
  • InterPro Domains
    IPR041337 Heterogeneous nuclear ribonucleoprotein Q acidic domain
    IPR034410 Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 1
    IPR034411 Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2
    IPR006535 HnRNP R/Q splicing factor
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
  • GlyGen
    Q8VHM5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 24
    cDNA 22
    Primer pair 1
    Other 1
    Antibodies 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:1917292, MGI:1921576
References
more
  • Summaries
    All 53
    Developmental Gene Expression 9
    Phenotypes 16
  • Earliest
    J:64914 Mizutani A, et al., SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. J Biol Chem. 2000 Mar 31;275(13):9823-31
  • Latest
    J:379675 Zare A, et al., Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer's disease. Transl Neurodegener. 2025 Jul 29;14(1):39
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory