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Brat1 Gene Detail
Summary
  • Symbol
    Brat1
  • Name
    BRCA1-associated ATM activator 1
  • Synonyms
    Baat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891679
    NCBI Gene: 231841
  • Gene Overview
    MyGene.info: BRAT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140705011-140719379 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891679
protein coding gene Chr5:140704782-140719379 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030305
protein coding gene Chr5:145820354-145835523 (+)
A/J MGP_AJ_G0030274
protein coding gene Chr5:139590064-139604427 (+)
AKR/J MGP_AKRJ_G0030206
protein coding gene Chr5:143949739-143965981 (+)
BALB/cJ MGP_BALBcJ_G0030291
protein coding gene Chr5:140835790-140850051 (+)
C3H/HeJ MGP_C3HHeJ_G0030002
protein coding gene Chr5:144755554-144770517 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030736
protein coding gene Chr5:151210198-151227554 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027954
protein coding gene Chr5:133421594-133436177 (+)
CAST/EiJ MGP_CASTEiJ_G0029407
protein coding gene Chr5:144178345-144194778 (+)
CBA/J MGP_CBAJ_G0029972
protein coding gene Chr5:157403666-157417993 (+)
DBA/2J MGP_DBA2J_G0030122
protein coding gene Chr5:139402512-139417595 (+)
FVB/NJ MGP_FVBNJ_G0030077
protein coding gene Chr5:138556886-138573385 (+)
LP/J MGP_LPJ_G0030208
protein coding gene Chr5:146428793-146443124 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030108
protein coding gene Chr5:159998194-160013392 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030776
protein coding gene Chr5:143789116-143804544 (+)
PWK/PhJ MGP_PWKPhJ_G0029122
protein coding gene Chr5:138426573-138441176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028958
protein coding gene Chr5:141497261-141515229 (+)
WSB/EiJ MGP_WSBEiJ_G0029481
protein coding gene Chr5:144580937-144596639 (+)



Homology
more
  • Human Ortholog
    BRAT1, BRCA1 associated ATM activator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRAT1, BRCA1 associated ATM activator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAAT1, C7orf27, NEDCAS, RMFSL
  • Links
    NCBI Gene ID: 221927
    neXtProt AC: NX_Q6PJG6
    UniProt: Q6PJG6

  • Chr Location
    7p22.3; chr7:2537810-2555758 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16776
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRAT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000148 Ensembl Gene Model | MGI Sequence Detail 14369 C57BL/6J ±  kb
transcript ENSMUST00000100505 Ensembl | MGI Sequence Detail 3431 Not Applicable  
polypeptide ENSMUSP00000098074 Ensembl | MGI Sequence Detail 867 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 6
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:60593 Millonig JH, et al., The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS [see comments]. Nature. 2000 Feb 17;403(6771):764-9
  • Latest
    J:222650 Low LH, et al., Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J Biol Chem. 2015 Mar 13;290(11):7141-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory