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Brat1 Gene Detail
Summary
  • Symbol
    Brat1
  • Name
    BRCA1-associated ATM activator 1
  • Synonyms
    Baat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891679
    NCBI Gene: 231841
  • Gene Overview
    MyGene.info: BRAT1
Location & Maps
more
  • Sequence Map
    Chr5:140705011-140719379 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14369 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BRAT1, BRCA1 associated ATM activator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRAT1, BRCA1 associated ATM activator 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAAT1, C7orf27, RMFSL
  • Links
    NCBI Gene ID: 221927
    neXtProt AC: NX_Q6PJG6

  • Chr Location
    7p22.3; chr7:2537810-2555758 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 16776
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BRAT1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human BRAT1 associations

Human Disease Mouse Models
       Rigidity and Multifocal Seizure Syndrome, Lethal Neonatal; RMFSL   OMIM: 614498
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    10
  • Gene trapped
    8
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024801 VEGA Gene Model | MGI Sequence Detail 14369 C57BL/6J ±  kb
transcript OTTMUST00000061083 VEGA | MGI Sequence Detail 3431 Not Applicable  
polypeptide OTTMUSP00000029892 VEGA | MGI Sequence Detail 867 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 6
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:60593 Millonig JH, et al., The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS [see comments]. Nature. 2000 Feb 17;403(6771):764-9
  • Latest
    J:222650 Low LH, et al., Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J Biol Chem. 2015 Mar 13;290(11):7141-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory