Nek6
Gene Detail

Symbol Name ID

Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 MGI:1891638

Synonyms

1300007C09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

24.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:38511643-38588041 bp, + strand From VEGA annotation of GRCm38   76399 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49379  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Nek6

Human homologs

Human Homolog		NEK6, NIMA-related kinase 6
NCBI Gene ID		10783
neXtProt AC		NX_Q9HC98
Human Synonyms		SID6-1512
Human Chr (Location)		9q33.3-q34.11; chr9:127019885-127114721 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(129) : Targeted(3) Gene trapped(126)
 

No significant homozygous or heterozygous mutant phenotype was detected in a high throughput screen of a targeted mutation.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	apoptotic process, cell cycle, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (142)    Tissues (139)    Images (30)
Theiler Stages: 9, 10, 14, 15, 17, 18, 20, 21, 22, 24, 25, 26, 28

Assay Type	Results
RNA in situ	131
Northern blot	11

cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(71) cDNA(70) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000012863 (Evidence)
Ensembl Gene Model	ENSMUSG00000026749 (Evidence)
Entrez Gene	59126 (Evidence)
UniGene	143818
DFCI	TC1576523, TC1676752, TC1695013
DoTS	DT.101737482, DT.533308, DT.91406535
NIA Mouse Gene Index	U001698
EC	2.7.11.1
Consensus CDS Project	CCDS16009.1
International Mouse Knockout Project Status	Nek6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012863	VEGA Gene Model | MGI Sequence Detail	76399	C57BL/6J
transcript	OTTMUST00000030841	VEGA | MGI Sequence Detail	3773	Not Applicable
polypeptide	OTTMUSP00000013815	VEGA | MGI Sequence Detail	313	Not Applicable

All sequences(60) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(227 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000011132	serine/threonine-protein kinase Nek6

References

(Earliest) J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)

Other accession IDs

MGI:1914728