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Nek6
Gene Detail
Symbol

Name
ID
Nek6
NIMA (never in mitosis gene a)-related expressed kinase 6
MGI:1891638
Synonyms
1300007C09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
24.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:38511643-38588041 bp, + strand
From VEGA annotation of GRCm38

  76399 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49379  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Nek6

Human
homologs
Human Homolog NEK6, NIMA-related kinase 6
NCBI Gene ID 10783
neXtProt AC  NX_Q9HC98
Human Synonyms  SID6-1512
Human Chr (Location)  9q33.3-q34.11; chr9:124257606-124352442 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(129) : Gene trapped(126) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
No significant homozygous or heterozygous mutant phenotype was detected in a high throughput screen of a targeted mutation.
 
Interactions
Nek6 interacts with 253 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (142)    Tissues (139)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 131
Northern blot 11
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(70) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000012863 (Evidence)
Ensembl Gene ModelENSMUSG00000026749 (Evidence)
Entrez Gene59126 (Evidence)
UniGene143818
DFCITC1576523, TC1695013, TC1676752
DoTSDT.91406535, DT.533308, DT.101737482
NIA Mouse Gene IndexU001698
EC2.7.11.1
Consensus CDS ProjectCCDS16009.1
International Mouse Knockout Project StatusNek6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012863 VEGA Gene Model | MGI Sequence Detail 76399 C57BL/6J ±  kb
transcript OTTMUST00000030843 VEGA | MGI Sequence Detail 1513 Not Applicable 
polypeptide OTTMUSP00000013817 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011132 serine/threonine-protein kinase Nek6
References
(Earliest) J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
(Latest) J:215160 Bian Z, et al., Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. PLoS One. 2014;9(4):e96095
All references(42)
Other
accession IDs
MGI:1914728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory