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Spsb3 Gene Detail
Summary
  • Symbol
    Spsb3
  • Name
    splA/ryanodine receptor domain and SOCS box containing 3
  • Synonyms
    2310012N15Rik, 3300001M01Rik, SSB3, Tce1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891471
    NCBI Gene: 79043
  • Gene Overview
    MyGene.info: SPSB3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24886643-24892152 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891471
protein coding gene Chr17:24886349-24892152 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023328
protein coding gene Chr17:23912140-23917482 (+)
A/J MGP_AJ_G0023288
protein coding gene Chr17:23248896-23254271 (+)
AKR/J MGP_AKRJ_G0023255
protein coding gene Chr17:23337428-23342770 (+)
BALB/cJ MGP_BALBcJ_G0023293
protein coding gene Chr17:23449387-23454813 (+)
C3H/HeJ MGP_C3HHeJ_G0023053
protein coding gene Chr17:23702026-23708108 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023736
protein coding gene Chr17:24974953-24980462 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021211
protein coding gene Chr17:20709097-20714466 (+)
CAST/EiJ MGP_CASTEiJ_G0022555
protein coding gene Chr17:23557271-23562648 (+)
CBA/J MGP_CBAJ_G0023029
protein coding gene Chr17:25816316-25824871 (+)
DBA/2J MGP_DBA2J_G0023158
protein coding gene Chr17:22841556-22847108 (+)
FVB/NJ MGP_FVBNJ_G0023128
protein coding gene Chr17:22562090-22567465 (+)
LP/J MGP_LPJ_G0023235
protein coding gene Chr17:24217392-24222745 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023147
protein coding gene Chr17:25508784-25514159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023774
protein coding gene Chr17:23621900-23627275 (+)
PWK/PhJ MGP_PWKPhJ_G0022304
protein coding gene Chr17:21596944-21602420 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022122
protein coding gene Chr17:21686137-21691587 (+)
WSB/EiJ MGP_WSBEiJ_G0022618
protein coding gene Chr17:23694535-23699844 (+)



Homology
more
  • Human Ortholog
    SPSB3, splA/ryanodine receptor domain and SOCS box containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPSB3, splA/ryanodine receptor domain and SOCS box containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C16orf31, SSB3
  • Links
    NCBI Gene ID: 90864
    neXtProt AC: NX_Q6PJ21
    UniProt: Q6PJ21

  • Chr Location
    16p13.3; chr16:1776712-1782605 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12322
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPSB3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024160 Ensembl Gene Model | MGI Sequence Detail 5510 C57BL/6J ±  kb
transcript ENSMUST00000168265 Ensembl | MGI Sequence Detail 1953 Not Applicable  
polypeptide ENSMUSP00000126878 Ensembl | MGI Sequence Detail 500 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001870 B30.2/SPRY domain
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR001496 SOCS box domain
    IPR003877 SPRY domain
    IPR035754 SPRY domain-containing SOCS box protein 3, SPRY domain
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914174, MGI:1916872
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
  • Latest
    J:232438 Ohmura S, et al., Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. J Clin Invest. 2016 Mar 1;126(3):865-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory