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Ripk2 Gene Detail
Summary
  • Symbol
    Ripk2
  • Name
    receptor (TNFRSF)-interacting serine-threonine kinase 2
  • Synonyms
    2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891456
    NCBI Gene: 192656
  • Gene Overview
    MyGene.info: RIPK2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:16122733-16163647 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 6.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891456
protein coding gene Chr4:16122733-16163676 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028076
protein coding gene Chr4:13009781-13059001 (-)
A/J MGP_AJ_G0028034
protein coding gene Chr4:12688039-12728861 (-)
AKR/J MGP_AKRJ_G0027999
protein coding gene Chr4:12926876-12966625 (-)
BALB/cJ MGP_BALBcJ_G0028045
protein coding gene Chr4:12605476-12646125 (-)
C3H/HeJ MGP_C3HHeJ_G0027775
protein coding gene Chr4:13030058-13069765 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028488
protein coding gene Chr4:13543648-13583070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025830
protein coding gene Chr4:11853209-11890852 (-)
CAST/EiJ MGP_CASTEiJ_G0027230
protein coding gene Chr4:12858642-12899419 (-)
CBA/J MGP_CBAJ_G0027748
protein coding gene Chr4:13875768-13920462 (-)
DBA/2J MGP_DBA2J_G0027891
protein coding gene Chr4:12510491-12550237 (-)
FVB/NJ MGP_FVBNJ_G0027857
protein coding gene Chr4:12268398-12306978 (-)
LP/J MGP_LPJ_G0028000
protein coding gene Chr4:13049570-13090700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027890
protein coding gene Chr4:14225575-14269502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028547
protein coding gene Chr4:12876072-12916804 (-)
PWK/PhJ MGP_PWKPhJ_G0026950
protein coding gene Chr4:12483590-12517109 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026779
protein coding gene Chr4:12751356-12789509 (-)
WSB/EiJ MGP_WSBEiJ_G0027307
protein coding gene Chr4:12912410-12954484 (-)



Homology
more
  • Human Ortholog
    RIPK2, receptor interacting serine/threonine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIPK2, receptor interacting serine/threonine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
  • Links
    NCBI Gene ID: 8767
    neXtProt AC: NX_O43353
    UniProt: O43353

  • Chr Location
    8q21.3; chr8:89757747-89791064 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. Macrophages homozygous for a knock-in allele show normal LPS signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041135 Ensembl Gene Model | MGI Sequence Detail 40915 C57BL/6J ±  kb
transcript ENSMUST00000037035 Ensembl | MGI Sequence Detail 2692 Not Applicable  
polypeptide ENSMUSP00000038833 Ensembl | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34205, MGI:106511, MGI:1917420
References
more
  • Summaries
    All 104
    Gene Ontology 16
    Phenotypes 61
  • Earliest
    J:35447 Corradi A, et al., cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. Genomics. 1996 Sep 1;36(2):288-95
  • Latest
    J:264577 Miller MH, et al., Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. J Leukoc Biol. 2018 Sep;104(3):447-459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory