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Ripk2 Gene Detail
Summary
  • Symbol
    Ripk2
  • Name
    receptor (TNFRSF)-interacting serine-threonine kinase 2
  • Synonyms
    2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891456
    NCBI Gene: 192656
  • Gene Overview
    MyGene.info: RIPK2
Location & Maps
more
  • Sequence Map
    Chr4:16122733-16163647 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40915 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 6.70 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RIPK2, receptor interacting serine/threonine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIPK2, receptor interacting serine/threonine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
  • Links
    NCBI Gene ID: 8767
    neXtProt AC: NX_O43353

  • Chr Location
    8q21; chr8:89757733-89791064 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
  • Incidental Mutations
Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. Macrophages homozygous for a knock-in allele show normal LPS signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004662 VEGA Gene Model | MGI Sequence Detail 40915 C57BL/6J ±  kb
transcript OTTMUST00000010515 VEGA | MGI Sequence Detail 2692 Not Applicable  
polypeptide OTTMUSP00000004983 VEGA | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34205, MGI:106511, MGI:1917420
References
more
  • Summaries
    All 87
    Gene Ontology 14
    Phenotypes 53
  • Earliest
    J:35447 Corradi A, et al., cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. Genomics. 1996 Sep 1;36(2):288-95
  • Latest
    J:226513 Burrows MP, et al., Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9973-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory