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BY367451 Gene Detail
Summary
  • Symbol
    BY367451
  • Name
    cDNA sequence, BY367451
  • Synonyms
    Atxn8os, Klhl1as, Sca8
  • Feature Type
    unclassified non-coding RNA gene
  • IDs
    MGI:1891412
    NCBI Gene: 108639
Location & Maps
more
  • Genetic Map
    Chromosome 14, Syntenic
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving BY367451
Mice both homozygous and heterozygous for disruption of this gene develop abnormalities in gait and defects in motor coordination with time. Dendritic atrophy of Purkinje cells is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Sequences &
Gene Models
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  • All Sequences
Representative SequencesLengthStrain/SpeciesFlank
transcript BY367451 GenBank | EMBL | DDBJ | MGI Sequence Detail 440 C57BL/6J  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 142
References
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  • Summaries
    All 6
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:62929 Nemes JP, et al., The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Hum Mol Genet. 2000 Jun 12;9(10):1543-51
  • Latest
    J:112937 He Y, et al., Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits. J Neurosci. 2006 Sep 27;26(39):9975-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory