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Pacsin3
Gene Detail
 Symbol
Name
ID
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
MGI:1891410
Synonyms 4921507A02Rik, 6330413E15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.61 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:91255954-91264679 bp, + strand
From VEGA annotation of GRCm38

  8726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: antigen EG13
Gene Tree: Pacsin3

Human
homologs
Human Homolog PACSIN3, protein kinase C and casein kinase substrate in neurons 3
NCBI Gene ID 29763
neXtProt AC  NX_Q9UKS6
Human Synonyms  SDPIII
Human Chr (Location)  11p12-p11.12; chr11:47177522-47186459 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(3) Gene trapped(2)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process endocytosis, membrane tubulation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function calcium channel inhibitor activity, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (32)    Tissues (32)    Images (8)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 32
cDNA source data(57)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(59) cDNA(58) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000014429 (Evidence)
Ensembl Gene ModelENSMUSG00000027257 (Evidence)
Entrez Gene80708 (Evidence)
UniGene236650
DFCITC1576833, TC1635945, TC1670240
NIA Mouse Gene IndexU002122
PDB3M3W, 3SYV, 3QE6
Consensus CDS ProjectCCDS16429.1
International Mouse Knockout Project StatusPacsin3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014429 VEGA Gene Model | MGI Sequence Detail 8726 C57BL/6J ±  kb
transcript OTTMUST00000034221 VEGA | MGI Sequence Detail 1993 Not Applicable 
polypeptide OTTMUSP00000015326 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(20) UniProt(9)
Polymorphisms SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000029663 protein kinase C and casein kinase substrate in neurons protein 3
References (Earliest) J:66805 Modregger J, et al., All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000 Dec;113 Pt 24:4511-21
(Latest) J:200757 Anggono V, et al., PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13976-81
All references(42)
Other
accession IDs
MGI:1917962, MGI:1921299, MGI:2139346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory