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Mov10l1 Gene Detail
Summary
  • Symbol
    Mov10l1
  • Name
    Mov10 like RISC complex RNA helicase 1
  • Synonyms
    CHAMP, Csm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891384
    NCBI Gene: 83456
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:88982909-89055152 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891384
protein coding gene Chr15:88982891-89055152 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022213
protein coding gene Chr15:90151977-90217758 (+)
A/J MGP_AJ_G0022172
protein coding gene Chr15:86708988-86772571 (+)
AKR/J MGP_AKRJ_G0022147
protein coding gene Chr15:89273774-89343718 (+)
BALB/cJ MGP_BALBcJ_G0022178
protein coding gene Chr15:86808839-86874871 (+)
C3H/HeJ MGP_C3HHeJ_G0021948
protein coding gene Chr15:89260612-89329748 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022623
protein coding gene Chr15:93431324-93506022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020148
protein coding gene Chr15:82937835-83000609 (+)
CAST/EiJ MGP_CASTEiJ_G0021470
protein coding gene Chr15:90045346-90109769 (+)
CBA/J MGP_CBAJ_G0021915
protein coding gene Chr15:96598071-96666192 (+)
DBA/2J MGP_DBA2J_G0022042
protein coding gene Chr15:86160940-86230309 (+)
FVB/NJ MGP_FVBNJ_G0022021
protein coding gene Chr15:85229895-85293984 (+)
LP/J MGP_LPJ_G0022113
protein coding gene Chr15:90322124-90387136 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022041
protein coding gene Chr15:101024429-101088007 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022638
protein coding gene Chr15:89302153-89377206 (+)
PWK/PhJ MGP_PWKPhJ_G0021211
protein coding gene Chr15:86206683-86273967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021045
protein coding gene Chr15:89046567-89111353 (+)
WSB/EiJ MGP_WSBEiJ_G0021519
protein coding gene Chr15:89793084-89861609 (+)



Homology
more
  • Human Ortholog
    MOV10L1, Mov10 like RISC complex RNA helicase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MOV10L1, Mov10 like RISC complex RNA helicase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHAMP, DJ402G11.8
  • Links
    NCBI Gene ID: 54456
    neXtProt AC: NX_Q9BXT6
    UniProt: Q9BXT6

  • Chr Location
    22q13.33; chr22:50090006-50161705 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele lacking the helicase domain exhibit male infertility due to meiotic arrest, apoptosis, and derepression of retrotransposons in male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015365 Ensembl Gene Model | MGI Sequence Detail 72244 C57BL/6J ±  kb
    transcript ENSMUST00000146993 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000118437 Ensembl | MGI Sequence Detail 1239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 20
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:255733 Ding D, et al., TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice. Nat Commun. 2018 Jan 9;9(1):127

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory