About   Help   FAQ
Mov10l1
Gene Detail
Symbol

Name
ID
Mov10l1
Moloney leukemia virus 10-like 1
MGI:1891384
Synonyms
CHAMP, Csm
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:88982909-89055148 bp, + strand
From VEGA annotation of GRCm38

  72240 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mov10l1

Human
homologs
Human Homolog MOV10L1, Mov10 RISC complex RNA helicase like 1
NCBI Gene ID 54456
neXtProt AC  NX_Q9BXT6
Human Synonyms  CHAMP, DJ402G11.8
Human Chr (Location)  22q13.33; chr22:50090006-50161690 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Radiation induced(1) Targeted(7)
Genomic Mutations involving Mov10l1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele lacking the helicase domain exhibit male infertility due to meiotic arrest, apoptosis, and derepression of retrotransposons in male germ cells.
 
Interactions
Mov10l1 interacts with 94 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell proliferation, multicellular organismal development, ...
Component cytoplasm
Function ATP binding, helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (61)    Tissues (30)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 14
Northern blot 36
RT-PCR 1
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024857 (Evidence)
Ensembl Gene ModelENSMUSG00000015365 (Evidence)
Entrez Gene83456 (Evidence)
UniGene358791
DFCITC1585453
DoTSDT.60100515, DT.525704
NIA Mouse Gene IndexU016548
EC3.6.4.13
Consensus CDS ProjectCCDS27737.1
International Mouse Knockout Project StatusMov10l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024857 VEGA Gene Model | MGI Sequence Detail 72240 C57BL/6J ±  kb
transcript OTTMUST00000061245 VEGA | MGI Sequence Detail 4133 Not Applicable 
polypeptide OTTMUSP00000029997 VEGA | MGI Sequence Detail 1239 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000031109 helicase Mov10l1
References
(Earliest) J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
(Latest) J:199322 Bao J, et al., Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Delta) mice. Genesis. 2013 Jul;51(7):481-90
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory