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Brdt
Gene Detail
Symbol

Name
ID
Brdt
bromodomain, testis-specific
MGI:1891374
Synonyms
7420412D09Rik, Brd6, Fsrg3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
52.23 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:107331159-107387058 bp, + strand
From VEGA annotation of GRCm38

  55900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BRDT
Gene Tree: Brdt

Human
homologs
BRDT, bromodomain, testis-specific
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 676
neXtProt AC: NX_Q58F21

Human Synonyms: BRD6, CT9

Human Chr (Location): 1p22.1; chr1:91949371-92014428 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit male infertility associated with abnormal spermatogenesis.
 
Interactions
Brdt interacts with 263 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, chromatin modification, ...
Component nucleus
Function histone binding, lysine-acetylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (176)    Tissues (163)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
RT-PCR 8
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase brdt ; ZFIN brdt    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017134 (Evidence)
Ensembl Gene Model ENSMUSG00000029279 (Evidence)
Entrez Gene 114642 (Evidence)
DFCI TC1616836, TC1599214, TC1585162, TC1607975
DoTS DT.94185901, DT.101703381, DT.524323
PDB 2WP2, 2WP1
Consensus CDS Project CCDS19500.1, CCDS39197.1
International Mouse Phenotyping Consortium Status Brdt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017134 VEGA Gene Model | MGI Sequence Detail 55900 C57BL/6J ±  kb
transcript OTTMUST00000041477 VEGA | MGI Sequence Detail 4745 Not Applicable 
polypeptide OTTMUSP00000018624 VEGA | MGI Sequence Detail 956 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(17) UniProt(2)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR027353 NET domain
Protein Ontology PR:000004810 bromodomain testis-specific protein
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190257 Berkovits BD, et al., The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids. Nucleic Acids Res. 2012 Aug;40(15):7162-75
All references(40)
Other
accession IDs
MGI:2442307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory