Brdt MGI Mouse Gene Detail - MGI:1891374 - bromodomain, testis-specific

Brdt Gene Detail

Symbol

Brdt
Name

bromodomain, testis-specific
Synonyms

7420412D09Rik, Brd6, Fsrg3

Feature Type

protein coding gene
IDs

MGI:1891374
NCBI Gene: 114642
Gene Overview

MyGene.info: BRDT
Alliance

gene page

Sequence Map

Chr5:107331159-107387058 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

55900 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 52.23 cM, cytoband E5
Mapping Data

2 experiments

Human Ortholog

BRDT, bromodomain testis associated

Vertebrate Orthologs

9

Human Ortholog

BRDT, bromodomain testis associated
Orthology source: HomoloGene, HGNC
Synonyms

BRD6, CT9, SPGF21
Links

HGNC:1105

NCBI Gene ID: 676

neXtProt AC: NX_Q58F21

UniProt: Q58F21
Chr Location

1p22.1; chr1:91949371-92014428 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21064
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: BRDT
Gene Tree

Brdt

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Phenotype Summary

18 phenotypes from 2 alleles in 4 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Brdt
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this genes leads to arrest of spermatogenesis and male infertility.

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All GO Annotations

23
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

179
Tissues

164
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase brdt

ZFIN brdt

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Brdt interacts with 263 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

49
RefSeq

21
UniProt

2
CCDS

CCDS19500.1, CCDS39197.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017134	VEGA Gene Model \| MGI Sequence Detail	55900	C57BL/6J	± kb
transcript	OTTMUST00000041477	VEGA \| MGI Sequence Detail	4745	Not Applicable
polypeptide	OTTMUSP00000018624	VEGA \| MGI Sequence Detail	956	Not Applicable

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SNPs within 2kb

272 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000004810 bromodomain testis-specific protein

(term hierarchy)
PDB

2WP1, 2WP2
InterPro Domains

IPR001487 Bromodomain

IPR018359 Bromodomain, conserved site

IPR036427 Bromodomain-like superfamily

IPR031354 Bromodomain protein 4, C-terminal

IPR027353 NET domain

IPR038336 NET domain superfamily

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All nucleic 14

cDNA 11

Primer pair 3

Microarray probesets 4

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MGI:2442307

Summaries

All 49

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:260590 Manterola M, et al., BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis. PLoS Genet. 2018 Mar;14(3):e1007209

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/31/2018 MGI 6.12