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Brdt Gene Detail
Summary
  • Symbol
    Brdt
  • Name
    bromodomain, testis-specific
  • Synonyms
    7420412D09Rik, Brd6, Fsrg3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891374
    NCBI Gene: 114642
  • Gene Overview
    MyGene.info: BRDT
Location & Maps
more
  • Sequence Map
    Chr5:107331159-107387058 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      55900 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 52.23 cM, cytoband E5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRDT, bromodomain testis associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRDT, bromodomain testis associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRD6, CT9
  • Links
    NCBI Gene ID: 676
    neXtProt AC: NX_Q58F21

  • Chr Location
    1p22.1; chr1:91949371-92014428 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 21064
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: BRDT
  • Gene Tree
    Brdt
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Brdt
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygous inactivation of this genes leads to arrest of spermatogenesis and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    179
  • Tissues
    164
  • cDNA Data
    10
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017134 VEGA Gene Model | MGI Sequence Detail 55900 C57BL/6J ±  kb
transcript OTTMUST00000041477 VEGA | MGI Sequence Detail 4745 Not Applicable  
polypeptide OTTMUSP00000018624 VEGA | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    272 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:2442307
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:232496 Barda S, et al., New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse. Gene Expr Patterns. 2016 Mar;20(2):130-7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory