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Brdt Gene Detail
Summary
  • Symbol
    Brdt
  • Name
    bromodomain, testis-specific
  • Synonyms
    7420412D09Rik, Brd6, Fsrg3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891374
    NCBI Gene: 114642
  • Gene Overview
    MyGene.info: BRDT
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:107331159-107387058 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 52.23 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891374
protein coding gene Chr5:107331084-107387061 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029835
protein coding gene Chr5:109352912-109417397 (+)
A/J MGP_AJ_G0029799
protein coding gene Chr5:105166206-105222811 (+)
AKR/J MGP_AKRJ_G0029744
protein coding gene Chr5:108561274-108625171 (+)
BALB/cJ MGP_BALBcJ_G0029811
protein coding gene Chr5:106301709-106357514 (+)
C3H/HeJ MGP_C3HHeJ_G0029533
protein coding gene Chr5:109008067-109068989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030265
protein coding gene Chr5:113853835-113912951 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027499
protein coding gene Chr5:100239697-100297089 (+)
CAST/EiJ MGP_CASTEiJ_G0028947
protein coding gene Chr5:107946375-108004506 (+)
CBA/J MGP_CBAJ_G0029501
protein coding gene Chr5:117661153-117735090 (+)
DBA/2J MGP_DBA2J_G0029647
protein coding gene Chr5:105302379-105359109 (+)
FVB/NJ MGP_FVBNJ_G0029604
protein coding gene Chr5:104035009-104092074 (+)
LP/J MGP_LPJ_G0029735
protein coding gene Chr5:109947609-110005223 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029636
protein coding gene Chr5:122599555-122659496 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030299
protein coding gene Chr5:108125186-108184130 (+)
PWK/PhJ MGP_PWKPhJ_G0028660
protein coding gene Chr5:104104429-104161355 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028498
protein coding gene Chr5:105635822-105698516 (+)
WSB/EiJ MGP_WSBEiJ_G0029020
protein coding gene Chr5:108420297-108479976 (+)



Homology
more
  • Human Ortholog
    BRDT, bromodomain testis associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRDT, bromodomain testis associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRD6, CT9, SPGF21
  • Links
    NCBI Gene ID: 676
    neXtProt AC: NX_Q58F21
    UniProt: Q58F21

  • Chr Location
    1p22.1; chr1:91949371-92014428 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21064
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRDT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human BRDT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this genes leads to arrest of spermatogenesis and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029279 Ensembl Gene Model | MGI Sequence Detail 55900 C57BL/6J ±  kb
    transcript ENSMUST00000031215 Ensembl | MGI Sequence Detail 4745 Not Applicable  
    polypeptide ENSMUSP00000031215 Ensembl | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442307
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:260590 Manterola M, et al., BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis. PLoS Genet. 2018 Mar;14(3):e1007209

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory