Brdt
Gene Detail

Symbol

Name
ID

Brdt
bromodomain, testis-specific
MGI:1891374

Synonyms

7420412D09Rik, Brd6, Fsrg3

Feature Type

protein coding gene

Genetic Map

Chromosome 5
52.23 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:107331159-107387058 bp, + strand From VEGA annotation of GRCm38   55900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:21064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Brdt

Human
homologs

Human Homolog		BRDT, bromodomain, testis-specific
NCBI Gene ID		676
neXtProt AC		NX_Q58F21
Human Synonyms		BRD6, CT9
Human Chr (Location)		1p22.1; chr1:91949371-92014428 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit male infertility associated with abnormal spermatogenesis.

 

Interactions

Brdt interacts with 263 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (23 annotations)

Process	cell differentiation, chromatin modification, ...
Component	nucleus
Function	histone binding, lysine-acetylated histone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (176)    Tissues (163)    Images (16)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	168
RT-PCR	8

cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000017134 (Evidence)
Ensembl Gene Model	ENSMUSG00000029279 (Evidence)
Entrez Gene	114642 (Evidence)
DFCI	TC1585162, TC1616836, TC1607975, TC1599214
DoTS	DT.94185901, DT.524323, DT.101703381
PDB	2WP2, 2WP1
Consensus CDS Project	CCDS19500.1, CCDS39197.1
International Mouse Knockout Project Status	Brdt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017134	VEGA Gene Model | MGI Sequence Detail	55900	C57BL/6J
transcript	OTTMUST00000041477	VEGA | MGI Sequence Detail	4745	Not Applicable
polypeptide	OTTMUSP00000018624	VEGA | MGI Sequence Detail	956	Not Applicable

All sequences(50) RefSeq(14) UniProt(3)

Polymorphisms

SNPs within 2kb(272 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR027353	NET domain
Protein Ontology	PR:000004810	bromodomain testis-specific protein

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190257 Berkovits BD, et al., The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids. Nucleic Acids Res. 2012 Aug;40(15):7162-75
All references(42)

Other
accession IDs

MGI:2442307