Prkag3
Gene Detail

Symbol Name ID

Prkag3 protein kinase, AMP-activated, gamma 3 non-catatlytic subunit MGI:1891343

Synonyms

AMPKg3, AMPKg3L, AMPKg3S

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:74739499-74749221 bp, - strand From VEGA annotation of GRCm38   9723 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: AMP-activated protein kinase, gamma-type regulatory subunit
Gene Tree: Prkag3

Human homologs

Human Homolog		PRKAG3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit
NCBI Gene ID		53632
neXtProt AC		NX_Q9UGI9
Human Synonyms		AMPKG3
Human Chr (Location)		2q35; chr2:219687106-219696512 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRKAG3

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice display impaired glycogen synthesis after exercise.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	fatty acid biosynthetic process, fatty acid metabolic process, ...
Component	AMP-activated protein kinase complex
Function	AMP-activated protein kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034607 (Evidence)
Ensembl Gene Model	ENSMUSG00000006542 (Evidence)
Entrez Gene	241113 (Evidence)
DFCI	TC1588409, TC1693087
DoTS	DT.101341463, DT.40165965, DT.55185903
NIA Mouse Gene Index	U021483
Consensus CDS Project	CCDS15055.1, CCDS35620.1
International Mouse Knockout Project Status	Prkag3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034607	VEGA Gene Model | MGI Sequence Detail	9723	C57BL/6J
transcript	OTTMUST00000087810	VEGA | MGI Sequence Detail	2255	Not Applicable
polypeptide	OTTMUSP00000047819	VEGA | MGI Sequence Detail	489	Not Applicable

All sequences(42) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000644	Cystathionine beta-synthase, core
Protein Ontology	PR:000013227	5'-AMP-activated protein kinase subunit gamma-3

References

(Earliest) J:62193 Milan D, et al., A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science. 2000 May 19;288(5469):1248-51
(Latest) J:186631 Pinter K, et al., Embryonic expression of AMPK gamma subunits and the identification of a novel gamma2 transcript variant in adult heart. J Mol Cell Cardiol. 2012 Sep;53(3):342-9
All references(37)