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Srpk3 Gene Detail
Summary
  • Symbol
    Srpk3
  • Name
    serine/arginine-rich protein specific kinase 3
  • Synonyms
    Mssk1, Stk23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891338
    NCBI Gene: 56504
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:73774405-73778925 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4521 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SRPK3, SRSF protein kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SRPK3, SRSF protein kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSSK1, MSSK-1, STK23
  • Links
    NCBI Gene ID: 26576
    neXtProt AC: NX_Q9UPE1
    UniProt: Q9UPE1

  • Chr Location
    Xq28; chrX:153781001-153785732 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice exhibit defects in skeletal muscle growth and myopathy of type 2 muscle fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017656 VEGA Gene Model | MGI Sequence Detail 4521 C57BL/6J ±  kb
    transcript OTTMUST00000042854 VEGA | MGI Sequence Detail 1981 Not Applicable  
    polypeptide OTTMUSP00000019243 VEGA | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      46 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 21
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory