Ubn1 MGI Mouse Gene Detail - MGI:1891307

Symbol

Ubn1
Name

ubinuclein 1
Synonyms

1110029L11Rik, 2610108L02Rik

Feature Type

protein coding gene
IDs

MGI:1891307
NCBI Gene: 170644
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:4867921-4904153 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.49 cM
Mapping Data

4 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891307	protein coding gene	Chr16:4867921-4904153 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022483	protein coding gene	Chr16:1579772-1619053 (+)
A/J	MGP_AJ_G0022445	protein coding gene	Chr16:1384971-1421868 (+)
AKR/J	MGP_AKRJ_G0022422	protein coding gene	Chr16:1584178-1619402 (+)
BALB/cJ	MGP_BALBcJ_G0022450	protein coding gene	Chr16:1538380-1574292 (+)
C3H/HeJ	MGP_C3HHeJ_G0022217	protein coding gene	Chr16:1605174-1642158 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022899	protein coding gene	Chr16:1663967-1701893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020420	protein coding gene	Chr16:1318358-1356062 (+)
CAST/EiJ	MGP_CASTEiJ_G0021743	protein coding gene	Chr16:1607466-1646481 (+)
CBA/J	MGP_CBAJ_G0022186	protein coding gene	Chr16:1761166-1799609 (+)
DBA/2J	MGP_DBA2J_G0022317	protein coding gene	Chr16:1486174-1521505 (+)
FVB/NJ	MGP_FVBNJ_G0022292	protein coding gene	Chr16:1480979-1517971 (+)
LP/J	MGP_LPJ_G0022385	protein coding gene	Chr16:1572591-1611350 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022314	protein coding gene	Chr16:1596125-1641415 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022911	protein coding gene	Chr16:1553760-1589607 (+)
PWK/PhJ	MGP_PWKPhJ_G0021483	protein coding gene	Chr16:1562610-1599976 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021314	protein coding gene	Chr16:1640216-1680369 (+)
WSB/EiJ	MGP_WSBEiJ_G0021792	protein coding gene	Chr16:1570983-1616264 (+)

Human Ortholog

UBN1, ubinuclein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBN1, ubinuclein 1
Synonyms

VT, VT4
Links

HGNC:12506

NCBI Gene ID: 29855

neXtProt AC: NX_Q9NPG3

UniProt: Q9NPG3
Chr Location

16p13.3; chr16:4846665-4882401 (+) GRCh38

MGI Vertebrate Homology

Ubn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBN1
Gene Tree

Ubn1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

168
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubn1

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All Sequences

80
RefSeq

26
UniProt

2
CCDS

CCDS27931.1, CCDS88873.1

Ensembl

ENSMUSG00000039473 (Evidence)
NCBI Gene

170644

			Length	Strain/Species	Flank
genomic	170644	NCBI Gene Model \| MGI Sequence Detail	36233	C57BL/6J	± kb
transcript	NM_026666	RefSeq \| MGI Sequence Detail	6470	ZRU/MplStud
polypeptide	Q4G0F8	UniProt \| EBI \| MGI Sequence Detail	1135	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017003 ubinuclein-1

(term hierarchy)
InterPro Domains

IPR014840 Hpc2-related domain

IPR026947 Ubinuclein middle domain

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All nucleic 168

cDNA 168

Microarray probesets 5

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MGI:1915552, MGI:1915969, MGI:2146362, MGI:2146625

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 6
Earliest

J:74234 Aho S, et al., Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. J Cell Biol. 2000 Mar 20;148(6):1165-76
Latest

J:330257 Smith R, et al., The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. Development. 2022 Mar 1;149(5):dev200044

TSS for Ubn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4781	Chr16:4867231-4867239 (+)	-686 bp
Tssr136901	Chr16:4867876-4867986 (+)	10 bp
Tssr136902	Chr16:4868063-4868074 (+)	148 bp
Tssr136903	Chr16:4898811-4898816 (+)	30,893 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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