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Ap1s3 Gene Detail
Summary
  • Symbol
    Ap1s3
  • Name
    adaptor-related protein complex AP-1, sigma 3
  • Synonyms
    Jr2, [s]3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891304
    NCBI Gene: 252903
Location & Maps
more
  • Sequence Map
    Chr1:79606876-79671972 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65097 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AP1S3, adaptor related protein complex 1 sigma 3 subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AP1S3, adaptor related protein complex 1 sigma 3 subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PSORS15
  • Links
    NCBI Gene ID: 130340
    neXtProt AC: NX_Q96PC3

  • Chr Location
    2q36.1; chr2:223755330-223837602 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AP1S3 associations

Human Disease Mouse Models
       Psoriasis 15, Pustular, Susceptibility To; PSORS15   OMIM: 616106
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Ap1s3
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034766 VEGA Gene Model | MGI Sequence Detail 65097 C57BL/6J ±  kb
transcript OTTMUST00000088357 VEGA | MGI Sequence Detail 2876 Not Applicable  
polypeptide OTTMUSP00000048141 VEGA | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    837 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004098 AP-1 complex subunit sigma-3
  • InterPro Domains
    IPR016635 Adaptor protein complex, sigma subunit
    IPR022775 AP complex, mu/sigma subunit
    IPR000804 Clathrin adaptor complex, small chain
    IPR011012 Longin-like domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 17

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:72903 Boettger-Tong HL, et al., Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1129-35
  • Latest
    J:224079 Ohana R, et al., MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development. 2015 Jul 15;142(14):2487-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory