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Kcnk6
Gene Detail
 Symbol
Name
ID
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
MGI:1891291
Synonyms D7Ertd764e, Toss, Twik2
Feature Type protein coding gene
Genetic Map
Chromosome 7
16.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:29221928-29232522 bp, - strand
From NCBI annotation of GRCm38

  10595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31266  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk6

Human
homologs
Human Homolog KCNK6, potassium channel, subfamily K, member 6
NCBI Gene ID 9424
neXtProt AC  NX_Q9Y257
Human Synonyms  K2p6.1, KCNK8, TOSS, TWIK2, TWIK-2
Human Chr (Location)  19q13.1; chr19:38319831-38333427 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele exhibit vascular dysfunction and hypertension.
 
Interactions
Kcnk6 interacts with 310 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process ion transport, negative regulation of systemic arterial blood pressure, ...
Component integral component of membrane, membrane
Function potassium channel activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (5)    Images (21)
Theiler Stages: 23, 25, 27, 28
Assay TypeResults
RNA in situ 21
RT-PCR 3
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000046410 (Evidence)
Entrez Gene52150 (Evidence)
UniGene24877
DFCITC1599926, TC1631391, TC1642243, TC1671877
DoTSDT.101126321
NIA Mouse Gene IndexU028349
Consensus CDS ProjectCCDS21068.1
International Mouse Knockout Project StatusKcnk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 52150 NCBI Gene Model | MGI Sequence Detail 10595 C57BL/6J ±  kb
transcript NM_001033525 RefSeq | MGI Sequence Detail 4089 C57BL/6 
polypeptide NP_001028697 RefSeq | MGI Sequence Detail 313 C57BL/6 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR003092 Two pore domain potassium channel, TASK family
InterPro IPR005409 Two pore domain potassium channel, TWIK-2
InterPro IPR005408 Two pore domain potassium channel, TWIK family
Protein Ontology PR:000002077 potassium channel subfamily K member 6
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:198943 Lloyd EE, et al., Endothelium-dependent relaxations in the aorta from K2p6.1 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013 Jul;305(1):R60-7
All references(33)
Other
accession IDs
MGI:1289340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory