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Kcnk6
Gene Detail
Symbol

Name
ID
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
MGI:1891291
Synonyms
D7Ertd764e, Toss, Twik2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:29221928-29232522 bp, - strand
From NCBI annotation of GRCm38

  10595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31266  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNK6
Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk6

Human
homologs
KCNK6, potassium channel, two pore domain subfamily K, member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9424
neXtProt AC: NX_Q9Y257

Human Synonyms: K2p6.1, KCNK8, TOSS, TWIK2, TWIK-2

Human Chr (Location): 19q13.1; chr19:38319814-38329014 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele exhibit vascular dysfunction and hypertension.
 
Interactions
Kcnk6 interacts with 309 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (5)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 3
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnk6    NEW 
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000046410 (Evidence)
Entrez Gene 52150 (Evidence)
UniGene 24877
DFCI TC1671877, TC1631391, TC1599926, TC1642243
DoTS DT.101126321
NIA Mouse Gene Index U028349
Consensus CDS Project CCDS21068.1
International Mouse Phenotyping Consortium Status Kcnk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 52150 NCBI Gene Model | MGI Sequence Detail 10595 C57BL/6J ±  kb
transcript NM_001033525 RefSeq | MGI Sequence Detail 4089 C57BL/6 
polypeptide NP_001028697 RefSeq | MGI Sequence Detail 313 C57BL/6 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR003092 Two pore domain potassium channel, TASK family
InterPro IPR005409 Two pore domain potassium channel, TWIK-2
InterPro IPR005408 Two pore domain potassium channel, TWIK family
Protein Ontology PR:000002077 potassium channel subfamily K member 6
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:198943 Lloyd EE, et al., Endothelium-dependent relaxations in the aorta from K2p6.1 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013 Jul;305(1):R60-7
All references(31)
Other
accession IDs
MGI:1289340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory