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Parp3 Gene Detail
Summary
  • Symbol
    Parp3
  • Name
    poly (ADP-ribose) polymerase family, member 3
  • Synonyms
    A930002C11Rik, Adprt3, Adprtl3, PARP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891258
    NCBI Gene: 235587
  • Gene Overview
    MyGene.info: PARP3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106470322-106476949 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891258
protein coding gene Chr9:106470322-106476949 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035234
protein coding gene Chr9:108281446-108291135 (-)
A/J MGP_AJ_G0035213
protein coding gene Chr9:104366598-104373219 (-)
AKR/J MGP_AKRJ_G0035145
protein coding gene Chr9:106968740-106975369 (-)
BALB/cJ MGP_BALBcJ_G0035207
protein coding gene Chr9:104052239-104058855 (-)
C3H/HeJ MGP_C3HHeJ_G0034917
protein coding gene Chr9:107382574-107389226 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035727
protein coding gene Chr9:111266140-111272742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032625
protein coding gene Chr9:101856966-101863741 (-)
CAST/EiJ MGP_CASTEiJ_G0034228
protein coding gene Chr9:107287503-107294182 (-)
CBA/J MGP_CBAJ_G0034885
protein coding gene Chr9:115199279-115205884 (-)
DBA/2J MGP_DBA2J_G0035046
protein coding gene Chr9:103829275-103835918 (-)
FVB/NJ MGP_FVBNJ_G0034994
protein coding gene Chr9:102608449-102615419 (-)
LP/J MGP_LPJ_G0035122
protein coding gene Chr9:108501862-108508458 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035033
protein coding gene Chr9:116792191-116799775 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035748
protein coding gene Chr9:107219224-107227150 (-)
PWK/PhJ MGP_PWKPhJ_G0033935
protein coding gene Chr9:104128239-104134909 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033770
protein coding gene Chr9:107289463-107296016 (-)
WSB/EiJ MGP_WSBEiJ_G0034349
protein coding gene Chr9:107115440-107122094 (-)



Homology
more
  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
  • Links
    NCBI Gene ID: 10039
    neXtProt AC: NX_Q9Y6F1
    UniProt: Q9Y6F1

  • Chr Location
    3p21.2; chr3:51942282-51948867 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4005
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 235587 NCBI Gene Model | MGI Sequence Detail 6628 C57BL/6J ±  kb
transcript NM_001311150 RefSeq | MGI Sequence Detail 2977 C57BL/6  
polypeptide NP_001298079 RefSeq | MGI Sequence Detail 533 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • EC
  • InterPro Domains
    IPR031275 Poly [ADP-ribose] polymerase 3
    IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
    IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
    IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamily
    IPR008893 WGR domain
    IPR036930 WGR domain superfamily
Molecular
Reagents
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  • All nucleic 39
    cDNA 39

    Microarray probesets 5
Other
Accession IDs
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MGI:2143354, MGI:2444599
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:79987 Urbanek P, et al., Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9. Folia Biol (Praha). 2002;48(5):182-91
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory