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Parp3 Gene Detail
Summary
  • Symbol
    Parp3
  • Name
    poly (ADP-ribose) polymerase family, member 3
  • Synonyms
    A930002C11Rik, Adprt3, Adprtl3, PARP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891258
    NCBI Gene: 235587
  • Gene Overview
    MyGene.info: PARP3
Location & Maps
more
  • Sequence Map
    Chr9:106470322-106476949 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6628 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.58 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
  • Links
    NCBI Gene ID: 10039
    neXtProt AC: NX_Q9Y6F1

  • Chr Location
    3p21.2; chr3:51942287-51948867 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4005
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PARP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033581 VEGA Gene Model | MGI Sequence Detail 6628 C57BL/6J ±  kb
transcript OTTMUST00000084584 VEGA | MGI Sequence Detail 2030 Not Applicable  
polypeptide OTTMUSP00000045605 VEGA | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR031275 Poly [ADP-ribose] polymerase 3
    IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
    IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
    IPR008893 WGR domain
Molecular
Reagents
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  • All nucleic 38
    cDNA 38

    Microarray probesets 5
Other
Accession IDs
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MGI:2143354, MGI:2444599
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:79987 Urbanek P, et al., Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9. Folia Biol (Praha). 2002;48(5):182-91
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory