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Crtap Gene Detail
Summary
  • Symbol
    Crtap
  • Name
    cartilage associated protein
  • Synonyms
    5730529N23Rik, CASP, Leprel3, P3h5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891221
    NCBI Gene: 56693
  • Gene Overview
    MyGene.info: CRTAP
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114375134-114390675 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 64.39 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891221
protein coding gene Chr9:114375131-114390712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035385
protein coding gene Chr9:116786592-116802201 (-)
A/J MGP_AJ_G0035365
protein coding gene Chr9:112204416-112546099 (-)
AKR/J MGP_AKRJ_G0035298
protein coding gene Chr9:115385855-115402762 (-)
BALB/cJ MGP_BALBcJ_G0035361
protein coding gene Chr9:112307958-112343934 (-)
C3H/HeJ MGP_C3HHeJ_G0035069
protein coding gene Chr9:115887740-115914364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035884
protein coding gene Chr9:119989165-120009683 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034374
protein coding gene Chr9:115485536-115753911 (-)
CBA/J MGP_CBAJ_G0035036
protein coding gene Chr9:124477673-124493319 (-)
DBA/2J MGP_DBA2J_G0035195
protein coding gene Chr9:112005839-112021750 (-)
FVB/NJ MGP_FVBNJ_G0035142
protein coding gene Chr9:110797713-110835840 (-)
LP/J MGP_LPJ_G0035274
protein coding gene Chr9:117132203-117160780 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035183
protein coding gene Chr9:125705237-125744092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035903
protein coding gene Chr9:115751211-115768659 (-)
PWK/PhJ MGP_PWKPhJ_G0034079
protein coding gene Chr9:111930814-112321519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033914
protein coding gene Chr9:115672233-115816279 (-)
WSB/EiJ MGP_WSBEiJ_G0034494
protein coding gene Chr9:115636390-115651828 (-)



Homology
more
  • Human Ortholog
    CRTAP, cartilage associated protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CRTAP, cartilage associated protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CASP, LEPREL3, OI7, P3H5
  • Links
    NCBI Gene ID: 10491
    neXtProt AC: NX_O75718
    UniProt: O75718

  • Chr Location
    3p22.3; chr3:33113958-33147773 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21280
    1 human;1 mouse;1 rat;1 chimpanzee;2 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRTAP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Crtap mouse models; 1 with human CRTAP associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes develop kyphoscoliosis and osteoporosis as a result of defects in bone formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032431 Ensembl Gene Model | MGI Sequence Detail 15542 C57BL/6J ±  kb
    transcript ENSMUST00000084881 Ensembl | MGI Sequence Detail 1674 Not Applicable  
    polypeptide ENSMUSP00000081941 Ensembl | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 1
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915200
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:56594 Morello R, et al., cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999 Jun;18(3):319-24
    • Latest
      J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory