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Crtap
Gene Detail
Symbol

Name
ID
Crtap
cartilage associated protein
MGI:1891221
Synonyms
5730529N23Rik, CASP, Leprel3, P3h5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
64.39 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:114375134-114390675 bp, - strand
From VEGA annotation of GRCm38

  15542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crtap

Human
homologs
Human Homolog   CRTAP, cartilage associated protein
NCBI Gene ID 10491
neXtProt AC  NX_O75718
Human Synonyms  CASP, LEPREL3, OI7, P3H5
Human Chr (Location)  3p22.3; chr3:33113958-33147773 (+)  GRCh38.p2
Disease Associations  (1) Diseases Associated with Human CRTAP
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Homozygotes develop kyphoscoliosis and osteoporosis as a result of defects in bone formation.
 
Human Diseases Modeled in Mice Using Crtap (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Crtap interacts with 77 markers (Mir7-2, Mir7b, Mir29a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (29)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 19
Northern blot 7
cDNA source data(69)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) Genomic(1) cDNA(70)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033583 (Evidence)
Ensembl Gene ModelENSMUSG00000032431 (Evidence)
Entrez Gene56693 (Evidence)
UniGene20904
DFCITC1664150, TC1623520, TC1578524
DoTSDT.494411
NIA Mouse Gene IndexU031394
Consensus CDS ProjectCCDS23592.1
International Mouse Knockout Project StatusCrtap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033583 VEGA Gene Model | MGI Sequence Detail 15542 C57BL/6J ±  kb
transcript OTTMUST00000084593 VEGA | MGI Sequence Detail 1674 Not Applicable 
polypeptide OTTMUSP00000045612 VEGA | MGI Sequence Detail 400 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000005900 cartilage-associated protein
References
(Earliest) J:56594 Morello R, et al., cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999 Jun;18(3):319-24
(Latest) J:213230 Grafe I, et al., Excessive transforming growth factor-beta signaling is a common mechanism in osteogenesis imperfecta. Nat Med. 2014 Jun;20(6):670-5
All references(39)
Disease annotation references (1)
Other
accession IDs
MGI:1915200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory