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Crtap Gene Detail
Summary
  • Symbol
    Crtap
  • Name
    cartilage associated protein
  • Synonyms
    5730529N23Rik, CASP, Leprel3, P3h5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891221
    NCBI Gene: 56693
  • Gene Overview
    MyGene.info: CRTAP
Location & Maps
more
  • Sequence Map
    Chr9:114375134-114390675 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 64.39 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CRTAP, cartilage associated protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CRTAP, cartilage associated protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CASP, LEPREL3, OI7, P3H5
  • Links
    NCBI Gene ID: 10491
    neXtProt AC: NX_O75718

  • Chr Location
    3p22.3; chr3:33113958-33147773 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21280
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;2 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CRTAP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Crtap mouse models; 1 with human CRTAP associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type VII; OI7   OMIM: 610682 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
Homozygotes develop kyphoscoliosis and osteoporosis as a result of defects in bone formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033583 VEGA Gene Model | MGI Sequence Detail 15542 C57BL/6J ±  kb
transcript OTTMUST00000084593 VEGA | MGI Sequence Detail 1674 Not Applicable  
polypeptide OTTMUSP00000045612 VEGA | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005900 cartilage-associated protein
  • InterPro Domains
    IPR033212 Cartilage-associated protein
Molecular
Reagents
less
  • All nucleic 71
    Genomic 1
    cDNA 70

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915200
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:56594 Morello R, et al., cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999 Jun;18(3):319-24
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory