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Zfp423
Gene Detail
 Symbol
Name
ID
Zfp423
zinc finger protein 423
MGI:1891217
Synonyms ataxia1, Ebfaz, mKIAA0760, Roaz, Zfp104
Feature Type protein coding gene
Genetic Map
Chromosome 8
42.29 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:87661810-87959595 bp, - strand
From VEGA annotation of GRCm38

  297786 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfp423

Human
homologs
Human Homolog ZNF423, zinc finger protein 423
NCBI Gene ID 23090
neXtProt AC  NX_Q2M1K9
Human Synonyms  Ebfaz, JBTS19, NPHP14, OAZ, Roaz, Zfp104, ZFP423
Human Chr (Location)  16q12; chr16:49490604-49857919 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZNF423
Mutations,
alleles, and
phenotypes
All mutations/alleles(520) : Chemically induced (ENU)(1) Gene trapped(516) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors.
 
Human Diseases Modeled Using Mouse Zfp423 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Zfp423 interacts with 215 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (270)    Tissues (184)    Images (30)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 19, 20, 22, 23, 28
Assay TypeResults
RNA in situ 243
Northern blot 5
Western blot 2
RT-PCR 20
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036956 (Evidence)
Ensembl Gene ModelENSMUSG00000045333 (Evidence)
Entrez Gene94187 (Evidence)
DFCITC1579774
DoTSDT.101151602, DT.102546773, DT.110885760, DT.60106736
NIA Mouse Gene IndexU030074
Consensus CDS ProjectCCDS52627.1
International Mouse Knockout Project StatusZfp423
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036956 VEGA Gene Model | MGI Sequence Detail 297786 C57BL/6J ±  kb
transcript OTTMUST00000094959 VEGA | MGI Sequence Detail 4907 Not Applicable 
polypeptide OTTMUSP00000052951 VEGA | MGI Sequence Detail 1292 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(16) UniProt(5)
Polymorphisms SNPs within 2kb(3164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017883 zinc finger protein 423
References (Earliest) J:40479 Tsai RY, et al., Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. J Neurosci. 1997 Jun 1;17(11):4159-69
(Latest) J:175442 Alcaraz WA, et al., Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice. Hum Mol Genet. 2011 Oct 1;20(19):3822-30
All references(54)
Disease annotation references (1)
Other
accession IDs
MGI:2671459, MGI:894654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory