Zfp423
Gene Detail

Symbol Name ID

Zfp423 zinc finger protein 423 MGI:1891217

Synonyms

ataxia1, Ebfaz, mKIAA0760, Roaz, Zfp104

Feature Type

protein coding gene

Genetic Map

Chromosome 8

42.29 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:87661810-87959595 bp, - strand From VEGA annotation of GRCm38   297786 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfp423

Human homologs

Human Homolog		ZNF423, zinc finger protein 423
NCBI Gene ID		23090
neXtProt AC		NX_Q2M1K9
Human Synonyms		Ebfaz, JBTS19, NPHP14, OAZ, Roaz, Zfp104, ZFP423
Human Chr (Location)		16q12; chr16:49524521-49860918 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ZNF423

Alleles and phenotypes

All alleles(520) : Targeted(3) Gene trapped(516) Chemically induced(1)
 

Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors.

 
Human Diseases Modeled Using Mouse Zfp423 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (277)    Tissues (189)    Images (30)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	243
Northern blot	5
Western blot	2
RT-PCR	27

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036956 (Evidence)
Ensembl Gene Model	ENSMUSG00000045333 (Evidence)
Entrez Gene	94187 (Evidence)
DFCI	TC1579774
DoTS	DT.101151602, DT.102546773, DT.110885760, DT.60106736
NIA Mouse Gene Index	U030074
Consensus CDS Project	CCDS52627.1
International Mouse Knockout Project Status	Zfp423

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036956	VEGA Gene Model | MGI Sequence Detail	297786	C57BL/6J
transcript	OTTMUST00000094959	VEGA | MGI Sequence Detail	4907	Not Applicable
polypeptide	OTTMUSP00000052951	VEGA | MGI Sequence Detail	1292	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(1995 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000017883	zinc finger protein 423

References

(Earliest) J:40479 Tsai RY, et al., Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. J Neurosci. 1997 Jun 1;17(11):4159-69
(Latest) J:175442 Alcaraz WA, et al., Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice. Hum Mol Genet. 2011 Oct 1;20(19):3822-30
All references(54)

Other accession IDs

MGI:2671459, MGI:894654