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Zfp423 Gene Detail
Summary
  • Symbol
    Zfp423
  • Name
    zinc finger protein 423
  • Synonyms
    ataxia1, Ebfaz, mKIAA0760, Roaz, Zfp104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891217
    NCBI Gene: 94187
  • Gene Overview
    MyGene.info: ZNF423
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:87661810-87959595 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      297786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 42.29 cM, cytoband C4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZNF423, zinc finger protein 423
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF423, zinc finger protein 423
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Ebfaz, hOAZ, JBTS19, NPHP14, OAZ, Roaz, Zfp104, ZFP423
  • Links
    NCBI Gene ID: 23090
    neXtProt AC: NX_Q2M1K9
    UniProt: Q2M1K9

  • Chr Location
    16q12.1; chr16:49487531-49857919 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9010
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF423
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Zfp423 mouse models; 1 with human ZNF423 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036956 VEGA Gene Model | MGI Sequence Detail 297786 C57BL/6J ±  kb
    transcript OTTMUST00000094959 VEGA | MGI Sequence Detail 4907 Not Applicable  
    polypeptide OTTMUSP00000052951 VEGA | MGI Sequence Detail 1292 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3147 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2671459, MGI:894654
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:263028 Roh HC, et al., Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 1;27(5):1121-1137.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory