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Zfp423 Gene Detail
Summary
  • Symbol
    Zfp423
  • Name
    zinc finger protein 423
  • Synonyms
    ataxia1, Ebfaz, mKIAA0760, Roaz, Zfp104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891217
    NCBI Gene: 94187
Location & Maps
more
  • Sequence Map
    Chr8:87661810-87959595 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      297786 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ZNF423, zinc finger protein 423
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF423, zinc finger protein 423
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Ebfaz, hOAZ, JBTS19, NPHP14, OAZ, Roaz, Zfp104, ZFP423
  • Links
    NCBI Gene ID: 23090
    neXtProt AC: NX_Q2M1K9

  • Chr Location
    16q12; chr16:49487531-49857919 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9010
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ZNF423
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zfp423 mouse models; 1 with human ZNF423 associations

Human Disease Mouse Models
       Dandy-Walker Syndrome; DWS   OMIM: 220200 View 1 model
       Nephronophthisis 14; NPHP14   OMIM: 614844
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    521
  • Chemically induced (ENU)
    1
  • Gene trapped
    516
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Zfp423
  • Incidental Mutations
Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036956 VEGA Gene Model | MGI Sequence Detail 297786 C57BL/6J ±  kb
transcript OTTMUST00000094959 VEGA | MGI Sequence Detail 4907 Not Applicable  
polypeptide OTTMUSP00000052951 VEGA | MGI Sequence Detail 1292 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3164 from dbSNP Build 137
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017883 zinc finger protein 423
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 12
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2671459, MGI:894654
References
more
  • Summaries
    All 52
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:40479 Tsai RY, et al., Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. J Neurosci. 1997 Jun 1;17(11):4159-69
  • Latest
    J:221935 Zhang S, et al., Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul;11(7):e1005344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory