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Chst2 Gene Detail
Summary
  • Symbol
    Chst2
  • Name
    carbohydrate sulfotransferase 2
  • Synonyms
    C130041E03Rik, Gn6st, GST-2, N-acetylglucosamine-6-O-sulfotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891160
    NCBI Gene: 54371
  • Gene Overview
    MyGene.info: CHST2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95400926-95407270 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 50.11 cM, cytoband E3.2-3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891160
protein coding gene Chr9:95399292-95407270 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035133
protein coding gene Chr9:96510297-96517797 (-)
A/J MGP_AJ_G0035114
protein coding gene Chr9:93167406-93174625 (-)
AKR/J MGP_AKRJ_G0035046
protein coding gene Chr9:95410682-95420035 (-)
BALB/cJ MGP_BALBcJ_G0035107
protein coding gene Chr9:92853713-92860935 (-)
C3H/HeJ MGP_C3HHeJ_G0034817
protein coding gene Chr9:95853327-95861837 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035627
protein coding gene Chr9:99269501-99276908 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032529
protein coding gene Chr9:91000542-91007649 (-)
CAST/EiJ MGP_CASTEiJ_G0034129
protein coding gene Chr9:95571452-95577988 (-)
CBA/J MGP_CBAJ_G0034785
protein coding gene Chr9:102709909-102717139 (-)
DBA/2J MGP_DBA2J_G0034947
protein coding gene Chr9:92696930-92704143 (-)
FVB/NJ MGP_FVBNJ_G0034895
protein coding gene Chr9:91547502-91554791 (-)
LP/J MGP_LPJ_G0035026
protein coding gene Chr9:96763883-96771114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034934
protein coding gene Chr9:104728099-104735465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035649
protein coding gene Chr9:95627239-95634557 (-)
PWK/PhJ MGP_PWKPhJ_G0033836
protein coding gene Chr9:92835136-92842519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033671
protein coding gene Chr9:95641008-95648256 (-)
WSB/EiJ MGP_WSBEiJ_G0034249
protein coding gene Chr9:95507928-95515278 (-)



Homology
more
  • Human Ortholog
    CHST2, carbohydrate sulfotransferase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHST2, carbohydrate sulfotransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6ST, glcNAc6ST-1, Gn6ST-1, GST2, GST-2, HEL-S-75
  • Links
    NCBI Gene ID: 9435
    neXtProt AC: NX_Q9Y4C5
    UniProt: Q9Y4C5

  • Chr Location
    3q24; chr3:143119776-143124014 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54371 NCBI Gene Model | MGI Sequence Detail 6345 C57BL/6J ±  kb
transcript NM_018763 RefSeq | MGI Sequence Detail 6256 C57BL/6  
polypeptide Q80WV3 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 25
    cDNA 20
    Primer pair 3
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGI:2143044, MGI:2143292, MGI:2444728
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:49573 Uchimura K, et al., Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem. 1998 Aug 28;273(35):22577-83
  • Latest
    J:242035 Zhang Z, et al., Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Proc Natl Acad Sci U S A. 2017 Apr 04;114(14):E2947-E2954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory