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Chst2
Gene Detail
 Symbol
Name
ID
Chst2
carbohydrate sulfotransferase 2
MGI:1891160
Synonyms C130041E03Rik, Gn6st, GST-2, N-acetylglucosamine-6-O-sulfotransferase
Feature Type protein coding gene
Genetic Map
Chromosome 9
50.11 cM, cytoband E3.2-3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:95400929-95407270 bp, - strand
From Ensembl annotation of GRCm38

  6342 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst2

Human
homologs
Human Homolog CHST2, carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
NCBI Gene ID 9435
neXtProt AC  NX_Q9Y4C5
Human Synonyms  C6ST, glcNAc6ST-1, Gn6ST-1, GST2, GST-2, HEL-S-75
Human Chr (Location)  3q24; chr3:143119776-143124014 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process carbohydrate metabolic process, inflammatory response, ...
Component Golgi apparatus, Golgi membrane, ...
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (308)    Tissues (188)    Images (61)
Theiler Stages: 18, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 279
Northern blot 27
RT-PCR 2
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000033350 (Evidence)
Entrez Gene54371 (Evidence)
DFCITC1582210, TC1624874, TC1631134, TC1645548
DoTSDT.101376416, DT.60100560, DT.91289123, DT.91336761
NIA Mouse Gene IndexU031196, U031197
EC2.8.2.-
Consensus CDS ProjectCCDS52888.1
International Mouse Knockout Project StatusChst2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033350 Ensembl Gene Model | MGI Sequence Detail 6342 C57BL/6J ±  kb
transcript ENSMUST00000036267 Ensembl | MGI Sequence Detail 6239 Not Applicable 
polypeptide ENSMUSP00000040775 Ensembl | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005475 carbohydrate sulfotransferase 2
References (Earliest) J:49573 Uchimura K, et al., Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem. 1998 Aug 28;273(35):22577-83
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(48)
Other
accession IDs
MGI:2143044, MGI:2143292, MGI:2444728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory