Chst2
Gene Detail

Symbol Name ID

Chst2 carbohydrate sulfotransferase 2 MGI:1891160

Synonyms

C130041E03Rik, Gn6st, GST-2, N-acetylglucosamine-6-O-sulfotransferase

Feature Type

protein coding gene

Genetic Map

Chromosome 9

50.11 cM, cytoband E3.2-3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:95400929-95407270 bp, - strand From Ensembl annotation of GRCm38   6342 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst2

Human homologs

Human Homolog		CHST2, carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
NCBI Gene ID		9435
neXtProt AC		NX_Q9Y4C5
Human Synonyms		C6ST, glcNAc6ST-1, Gn6ST-1, GST2, GST-2
Human Chr (Location)		3q24; chr3:142838618-142842856 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	carbohydrate metabolic process, inflammatory response, ...
Component	Golgi apparatus, Golgi membrane, ...
Function	N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (276)    Tissues (156)    Images (59)
Theiler Stages: 18, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	247
Northern blot	27
RT-PCR	2

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000033350 (Evidence)
Entrez Gene	54371 (Evidence)
DFCI	TC1582210, TC1624874, TC1631134, TC1645548
DoTS	DT.101376416, DT.60100560, DT.91289123, DT.91336761
NIA Mouse Gene Index	U031196, U031197
EC	2.8.2.-
Consensus CDS Project	CCDS52888.1
International Mouse Knockout Project Status	Chst2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000033350	Ensembl Gene Model | MGI Sequence Detail	6342	C57BL/6J
transcript	ENSMUST00000036267	Ensembl | MGI Sequence Detail	6239	Not Applicable
polypeptide	ENSMUSP00000040775	Ensembl | MGI Sequence Detail	530	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016469	Carbohydrate sulfotransferase
InterPro	IPR000863	Sulfotransferase domain
Protein Ontology	PR:000005475	carbohydrate sulfotransferase 2

References

(Earliest) J:49573 Uchimura K, et al., Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem. 1998 Aug 28;273(35):22577-83
(Latest) J:177302 Ohmichi Y, et al., Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. J Exp Med. 2011 May 9;208(5):1015-25
All references(44)

Other accession IDs

MGI:2143044, MGI:2143292, MGI:2444728