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Styx Gene Detail
Summary
  • Symbol
    Styx
  • Name
    serine/threonine/tyrosine interaction protein
  • Synonyms
    0610039A20Rik, STNS (alternatively spliced intron of Styx)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891150
    NCBI Gene: 56291
Location & Maps
more
  • Sequence Map
    Chr14:45351473-45373585 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22113 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    STYX, serine/threonine/tyrosine interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STYX, serine/threonine/tyrosine interacting protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6815
    neXtProt AC: NX_Q8WUJ0

  • Chr Location
    14q22.1; chr14:52730165-52774989 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41331
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: STYX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    1 involving Styx
  • Incidental Mutations
Males homozygous for a targeted null mutation are sterile due to a deficiency of germ cells at the immature, round, and elongating spermatid stages. Residual epididymal sperm have head abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase styx
    ZFIN styx
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053205 Ensembl Gene Model | MGI Sequence Detail 22113 C57BL/6J ±  kb
transcript ENSMUST00000111835 Ensembl | MGI Sequence Detail 672 Not Applicable  
polypeptide ENSMUSP00000107466 Ensembl | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    241 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015808 serine/threonine/tyrosine-interacting protein
  • InterPro Domains
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 9
Other
Accession IDs
less
MGI:1918939
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory