Kcne4 MGI Mouse Gene Detail - MGI:1891125 - potassium voltage-gated channel, Isk-related subfamily, gene 4

Symbol

Kcne4
Name

potassium voltage-gated channel, Isk-related subfamily, gene 4
Synonyms

MiRP3

Feature Type

protein coding gene
IDs

MGI:1891125
NCBI Gene: 57814
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:78794628-78797749 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 40.89 cM
Mapping Data

2 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891125	protein coding gene	Chr1:78794475-78797749 (+)
129S1/SvImJ	ENSMUSG00200032971	protein coding gene	Chr1:76463570-76466853 (+)
A/J	ENSMUSG00195010154	protein coding gene	Chr1:75883855-75887149 (+)
AKR/J	ENSMUSG00220010150	protein coding gene	Chr1:76048050-76051324 (+)
BALB/cJ	ENSMUSG00180018661	protein coding gene	Chr1:76146431-76149721 (+)
C3H/HeJ	ENSMUSG00175016653	protein coding gene	Chr1:76288710-76292000 (+)
C57BL/6NJ	ENSMUSG00215015176	protein coding gene	Chr1:76201273-76204543 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014314	protein coding gene	Chr1:72179818-72183083 (+)
CAST/EiJ	ENSTCUG00005025441	protein coding gene	Chr1:75906492-75909768 (+)
CBA/J	ENSMUSG00210032573	protein coding gene	Chr1:76024114-76027384 (+)
DBA/2J	ENSMUSG00185029084	protein coding gene	Chr1:77076041-77079311 (+)
FVB/NJ	ENSMUSG00205036222	protein coding gene	Chr1:75602063-75605319 (+)
JF1/MsJ	ENSUMUG00000001795	protein coding gene	Chr1:75935679-75938978 (+)
LP/J	ENSMUSG00230009428	protein coding gene	Chr1:77038911-77042202 (+)
NOD/ShiLtJ	ENSMUSG00190030609	protein coding gene	Chr1:76223821-76227091 (+)
NZO/HlLtJ	ENSMUSG00225040208	protein coding gene	Chr1:80276605-80279941 (+)
PWK/PhJ	ENSLUMG00010013223	protein coding gene	Chr1:75537418-75540706 (+)
SPRET/EiJ	ENSMSPG00010019485	protein coding gene	Chr1:77699540-77702837 (+)
WSB/EiJ	ENSIUOG00005012700	protein coding gene	Chr1:75813427-75816717 (+)

Human Ortholog

KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4
Synonyms

MIRP3
Links

HGNC:6244

NCBI Gene ID: 23704

UniProt: Q8WWG9
Chr Location

2q36.1; chr2:223052190-223198399 (+) GRCh38

MGI Vertebrate Homology

Kcne4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNE4
Gene Tree

Kcne4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Kcne4
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous deletion of this gene impairs cardiac ventricular repolarization in an age and sex-dependent manner, with a prolonged QT interval only occurring similarly in both males and females after female menopause.

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All GO Annotations

25
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

603
Tissues

6
cDNA Data

16
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcne4

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All Sequences

38
RefSeq

2
UniProt

3
CCDS

CCDS15088.1

Ensembl

ENSMUSG00000047330 (Evidence)
NCBI Gene

57814

			Length	Strain/Species	Flank
genomic	57814	NCBI Gene Model \| MGI Sequence Detail	3122	C57BL/6J	± kb
transcript	NM_021342	RefSeq \| MGI Sequence Detail	2524	C57BL/6
polypeptide	Q9WTW3	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009258 potassium voltage-gated channel subfamily E member 4

(term hierarchy)
InterPro Domains

IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
GlyGen

Q9WTW3 2 sites

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 3

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MGI:2138590

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 12

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:352579 Sole L, et al., Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex. Cells. 2020 May 2;9(5)

TSS for Kcne4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7586	Chr1:78794626-78794630 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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