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Kcne3 Gene Detail
Summary
  • Symbol
    Kcne3
  • Name
    potassium voltage-gated channel, Isk-related subfamily, gene 3
  • Synonyms
    2210017H05Rik, MiRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891124
    NCBI Gene: 57442
  • Gene Overview
    MyGene.info: KCNE3
Location & Maps
more
  • Sequence Map
    Chr7:100176502-100184869 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8368 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.33 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCNE3, potassium voltage-gated channel subfamily E regulatory subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNE3, potassium voltage-gated channel subfamily E regulatory subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOKPP, HYPP, MiRP2
  • Links
    NCBI Gene ID: 10008
    neXtProt AC: NX_Q9Y6H6

  • Chr Location
    11q13.4; chr11:74454841-74467557 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3994
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KCNE3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KCNE3 associations

Human Disease Mouse Models
       Brugada Syndrome 6; BRGDA6   OMIM: 613119
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Kcne3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia. Another knock-out allele shows age-dependent alterations in action potential and firing properties of spiral ganglion neurons in the cochlea.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059142 VEGA Gene Model | MGI Sequence Detail 8368 C57BL/6J ±  kb
transcript OTTMUST00000145054 VEGA | MGI Sequence Detail 1323 Not Applicable  
polypeptide OTTMUSP00000075574 VEGA | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009257 potassium voltage-gated channel subfamily E member 3
  • InterPro Domains
    IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
    IPR005426 Potassium channel, voltage-dependent, beta subunit, KCNE3
Molecular
Reagents
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  • All nucleic 25
    cDNA 23
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917404
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:64949 Abbott GW, et al., MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory