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Kcne3
Gene Detail
 Symbol
Name
ID
Kcne3
potassium voltage-gated channel, Isk-related subfamily, gene 3
MGI:1891124
Synonyms 2210017H05Rik, MiRP2
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.33 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:100176670-100184869 bp, + strand
From NCBI annotation of GRCm38

  8200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Kcne3

Human
homologs
Human Homolog KCNE3, potassium voltage-gated channel, Isk-related family, member 3
NCBI Gene ID 10008
neXtProt AC  NX_Q9Y6H6
Human Synonyms  HOKPP, HYPP, MiRP2
Human Chr (Location)  11q13.4; chr11:74454841-74467555 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNE3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia.
 
Interactions
Kcne3 interacts with 61 markers (Mir1a-1, Mir1a-2, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function potassium channel activity, potassium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (44)    Tissues (12)    Images (24)
Theiler Stages: 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 38
RT-PCR 6
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035165 (Evidence)
Entrez Gene57442 (Evidence)
UniGene282386
DFCITC1584660, TC1591381, TC1667704, TC1691169
DoTSDT.101334522, DT.110992643, DT.528716, DT.55214676, DT.94224665
NIA Mouse Gene IndexU008447
Consensus CDS ProjectCCDS21495.1
International Mouse Knockout Project StatusKcne3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57442 NCBI Gene Model | MGI Sequence Detail 8200 C57BL/6J ±  kb
transcript NM_001190870 RefSeq | MGI Sequence Detail 1333 C57BL/6 
polypeptide Q9WTW2 UniProt | EBI | MGI Sequence Detail 103 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(22) UniProt(2)
Polymorphisms SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
InterPro IPR005426 Potassium channel, voltage-dependent, beta subunit, KCNE3
Protein Ontology PR:000009257 potassium voltage-gated channel subfamily E member 3
Graphical View of Protein Domain Structure
References (Earliest) J:64949 Abbott GW, et al., MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87
(Latest) J:210381 Hu Z, et al., Kcne3 deletion initiates extracardiac arrhythmogenesis in mice. FASEB J. 2014 Feb;28(2):935-45
All references(40)
Other
accession IDs
MGI:1917404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory