Kcne3
Gene Detail

Symbol Name ID

Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 MGI:1891124

Synonyms

2210017H05Rik, MiRP2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.33 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:100176670-100184869 bp, + strand From NCBI annotation of GRCm38   8200 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Kcne3

Human homologs

Human Homolog		KCNE3, potassium voltage-gated channel, Isk-related family, member 3
NCBI Gene ID		10008
neXtProt AC		NX_Q9Y6H6
Human Synonyms		HOKPP, HYPP, MiRP2
Human Chr (Location)		11q13.4; chr11:74165886-74178600 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KCNE3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit decreased cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	ion channel activity, potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (44)    Tissues (10)    Images (24)
Theiler Stages: 22, 23, 25, 28

Assay Type	Results
RNA in situ	38
RT-PCR	6

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035165 (Evidence)
Entrez Gene	57442 (Evidence)
UniGene	282386
DFCI	TC1584660, TC1591381, TC1667704, TC1691169
DoTS	DT.101334522, DT.110992643, DT.528716, DT.55214676, DT.94224665
NIA Mouse Gene Index	U008447
Consensus CDS Project	CCDS21495.1
International Mouse Knockout Project Status	Kcne3

Sequences

Length	Strain/Species
genomic	57442	NCBI Gene Model | MGI Sequence Detail	8200	C57BL/6J
transcript	NM_001190870	RefSeq | MGI Sequence Detail	1333	C57BL/6
polypeptide	Q9WTW2	UniProt | EBI | MGI Sequence Detail	103	Not Applicable

All sequences(45) RefSeq(10) UniProt(2)

Polymorphisms

SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000369	Potassium channel, voltage-dependent, beta subunit, KCNE
InterPro	IPR005426	Potassium channel, voltage-dependent, beta subunit, KCNE3
Protein Ontology	PR:000009257	potassium voltage-gated channel subfamily E member 3

Graphical View of Protein Domain Structure

References

(Earliest) J:64949 Abbott GW, et al., MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87
(Latest) J:188649 Takase H, et al., Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood. 2012 Jul 26;120(4):914-23
All references(37)

Other accession IDs

MGI:1917404