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Aqp9 Gene Detail
Summary
  • Symbol
    Aqp9
  • Name
    aquaporin 9
  • Synonyms
    1700020I22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891066
    NCBI Gene: 64008
  • Gene Overview
    MyGene.info: AQP9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:71110659-71168682 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 39.85 cM, cytoband D
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AQP9, aquaporin 9
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AQP9, aquaporin 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AQP-9, HsT17287, SSC1, T17287
  • Links
    NCBI Gene ID: 366
    neXtProt AC: NX_O43315
    UniProt: O43315

  • Chr Location
    15q21.3; chr15:58138169-58185911 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41405
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AQP9
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have increased glycerol and triglyceride levels, increased resistance to glycerol-induced lysis, decreased glycerol permeability, and decreased susceptibility to the early stages of parasitic infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023895 VEGA Gene Model | MGI Sequence Detail 58024 C57BL/6J ±  kb
    transcript OTTMUST00000058379 VEGA | MGI Sequence Detail 2643 Not Applicable  
    polypeptide OTTMUSP00000028277 VEGA | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      398 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919512, MGI:2143005
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:63371 Edashige K, et al., Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000 Mar;40(2):171-5
    • Latest
      J:259712 Stahl K, et al., Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One. 2018;13(3):e0194896

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory