Zfpl1 MGI Mouse Gene Detail - MGI:1891017 - zinc finger like protein 1

Symbol

Zfpl1
Name

zinc finger like protein 1
Synonyms

1500015B20Rik

Feature Type

protein coding gene
IDs

MGI:1891017
NCBI Gene: 81909
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:6130792-6134986 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

21 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891017	protein coding gene	Chr19:6130787-6135005 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024746	protein coding gene	Chr19:3109955-3114385 (-)
A/J	MGP_AJ_G0024712	protein coding gene	Chr19:2939674-2943851 (-)
AKR/J	MGP_AKRJ_G0024685	protein coding gene	Chr19:3029987-3034164 (-)
BALB/cJ	MGP_BALBcJ_G0024712	protein coding gene	Chr19:2933993-2938170 (-)
C3H/HeJ	MGP_C3HHeJ_G0024480	protein coding gene	Chr19:3048682-3052859 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025158	protein coding gene	Chr19:3170812-3175130 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022592	protein coding gene	Chr19:2867690-2871845 (-)
CAST/EiJ	MGP_CASTEiJ_G0023952	protein coding gene	Chr19:3055738-3059917 (-)
CBA/J	MGP_CBAJ_G0024452	protein coding gene	Chr19:3321560-3325580 (-)
DBA/2J	MGP_DBA2J_G0024579	protein coding gene	Chr19:2929907-2934085 (-)
FVB/NJ	MGP_FVBNJ_G0024545	protein coding gene	Chr19:2940976-2945153 (-)
LP/J	MGP_LPJ_G0024665	protein coding gene	Chr19:3088209-3092391 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024574	protein coding gene	Chr19:3141295-3145472 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025206	protein coding gene	Chr19:3060980-3065163 (-)
PWK/PhJ	MGP_PWKPhJ_G0023698	protein coding gene	Chr19:2958556-2962879 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023503	protein coding gene	Chr19:3018229-3022402 (-)
WSB/EiJ	MGP_WSBEiJ_G0024014	protein coding gene	Chr19:3066610-3070786 (-)

Human Ortholog

ZFPL1, zinc finger protein like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFPL1, zinc finger protein like 1
Synonyms

D11S750, MCG4
Links

HGNC:12868

NCBI Gene ID: 7542

neXtProt AC: NX_O95159

UniProt: O95159
Chr Location

11q13.1; chr11:65084210-65088398 (+) GRCh38

MGI Vertebrate Homology

Zfpl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFPL1
Gene Tree

Zfpl1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

63
cDNA Data

63
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfpl1

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All Sequences

64
RefSeq

8
UniProt

7
CCDS

CCDS29492.1

Ensembl

ENSMUSG00000024792 (Evidence)
NCBI Gene

81909

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024792	Ensembl Gene Model \| MGI Sequence Detail	4195	C57BL/6J	± kb
transcript	ENSMUST00000025707	Ensembl \| MGI Sequence Detail	1287	Not Applicable
polypeptide	ENSMUSP00000025707	Ensembl \| MGI Sequence Detail	310	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017651 zinc finger protein-like 1

(term hierarchy)
InterPro Domains

IPR039043 Zinc finger protein-like 1

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 66

cDNA 63

Primer pair 3

Microarray probesets 3

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MGI:1916239

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 10
Earliest

J:48337 Hoppener JW, et al., A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Genomics. 1998 Jun 1;50(2):251-9
Latest

J:317829 Wang F, et al., Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7;8(1):eabg5369

TSS for Zfpl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157827	Chr19:6134971-6134987 (-)	7 bp
Tssr157826	Chr19:6134903-6134970 (-)	49 bp
Tssr157825	Chr19:6134728-6134761 (-)	241 bp
Tssr157824	Chr19:6134709-6134720 (-)	271 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23