About   Help   FAQ
F12 Gene Detail
Summary
  • Symbol
    F12
  • Name
    coagulation factor XII (Hageman factor)
  • Synonyms
    FXII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891012
    NCBI Gene: 58992
  • Gene Overview
    MyGene.info: F12
Location & Maps
more
  • Sequence Map
    Chr13:55417958-55426793 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8836 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    F12, coagulation factor XII
  • Vertebrate Orthologs
    8
  • Human Ortholog
    F12, coagulation factor XII
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HAE3, HAEX, HAF
  • Links
    NCBI Gene ID: 2161
    neXtProt AC: NX_P00748

  • Chr Location
    5q35.3; chr5:177402138-177416524 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with F12 mouse models; 2 with human F12 associations

Human Disease Mouse Models
       Factor XII Deficiency   OMIM: 234000 View 1 model
       Angioedema, Hereditary, Type III; HAE3   OMIM: 610618
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving F12
  • Incidental Mutations
Mice homozygous for a knock-out allele are protected from ischemic brain injury in an experimental stroke model, without exhibiting an increase in infarct-associated hemorrhage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035495 VEGA Gene Model | MGI Sequence Detail 8836 C57BL/6J ±  kb
transcript OTTMUST00000090888 VEGA | MGI Sequence Detail 1960 Not Applicable  
polypeptide OTTMUSP00000049979 VEGA | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 49
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:74089 Ong K, et al., Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
  • Latest
    J:226441 Nickel KF, et al., The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10;126(11):1379-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory