Vsx1
Gene Detail

Symbol Name ID

Vsx1 visual system homeobox 1 homolog (zebrafish) MGI:1890816

Synonyms

CHX10-like

Feature Type

protein coding gene

Genetic Map

Chromosome 2

74.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:150680699-150689360 bp, - strand From VEGA annotation of GRCm38   8662 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Vsx1

Human homologs

Human Homolog		VSX1, visual system homeobox 1
NCBI Gene ID		30813
neXtProt AC		NX_Q9NZR4
Human Synonyms		CAASDS, KTCN, KTCN1, PPCD, PPD, RINX
Human Chr (Location)		20p11.21; chr20:25051521-25063015 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human VSX1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mutation of this locus impairs cone bipolar cell differentiation and affects retinal electrophysiology.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	multicellular organismal development, neuron development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (103)    Tissues (103)   
Theiler Stages: 9, 11, 13, 15, 17, 19, 22

Assay Type	Results
RNA in situ	97
RT-PCR	6

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015757 (Evidence)
Ensembl Gene Model	ENSMUSG00000033080 (Evidence)
Entrez Gene	114889 (Evidence)
UniGene	207061
DFCI	TC1588095
DoTS	DT.91371161
NIA Mouse Gene Index	U023482
Consensus CDS Project	CCDS16860.1
International Mouse Knockout Project Status	Vsx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015757	VEGA Gene Model | MGI Sequence Detail	8662	C57BL/6J
transcript	OTTMUST00000037425	VEGA | MGI Sequence Detail	3794	Not Applicable
polypeptide	OTTMUSP00000016771	VEGA | MGI Sequence Detail	363	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023339	CVC domain
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000017354	visual system homeobox 1

References

(Earliest) J:71130 Ohtoshi A, et al., Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina. Biochem Biophys Res Commun. 2001 Aug 10;286(1):133-40
(Latest) J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
All references(42)