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Vsx1
Gene Detail
Symbol

Name
ID
Vsx1
visual system homeobox 1 homolog (zebrafish)
MGI:1890816
Synonyms
CHX10-like
Feature Type
protein coding gene
Genetic Map
Chromosome 2
74.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:150680702-150689360 bp, - strand
From VEGA annotation of GRCm38

  8659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Vsx1

Human
homologs
Human Homolog VSX1, visual system homeobox 1
NCBI Gene ID 30813
neXtProt AC  NX_Q9NZR4
Human Synonyms  CAASDS, KTCN, KTCN1, PPCD, PPCD1, PPD, RINX
Human Chr (Location)  20p11.21; chr20:25070885-25082379 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human VSX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mutation of this locus impairs cone bipolar cell differentiation and affects retinal electrophysiology.
 
Interactions
Vsx1 interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process multicellular organismal development, neuron development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (103)    Tissues (103)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
RT-PCR 6
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015757 (Evidence)
Ensembl Gene ModelENSMUSG00000033080 (Evidence)
Entrez Gene114889 (Evidence)
UniGene207061
DFCITC1588095
DoTSDT.91371161
NIA Mouse Gene IndexU023482
Consensus CDS ProjectCCDS16860.1
International Mouse Knockout Project StatusVsx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015757 VEGA Gene Model | MGI Sequence Detail 8659 C57BL/6J ±  kb
transcript OTTMUST00000037425 VEGA | MGI Sequence Detail 3791 Not Applicable 
polypeptide OTTMUSP00000016771 VEGA | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023339 CVC domain
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000017354 visual system homeobox 1
References
(Earliest) J:71130 Ohtoshi A, et al., Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina. Biochem Biophys Res Commun. 2001 Aug 10;286(1):133-40
(Latest) J:211952 Bai L, et al., Birth of cone bipolar cells, but not rod bipolar cells, is associated with existing RGCs. PLoS One. 2014;9(1):e83686
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory