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Vsx1
Gene Detail
Symbol

Name
ID
Vsx1
visual system homeobox 1 homolog (zebrafish)
MGI:1890816
Synonyms
CHX10-like
Feature Type
protein coding gene
Genetic Map
Chromosome 2
74.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:150680702-150689360 bp, - strand
From VEGA annotation of GRCm38

  8659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: VSX1
Gene Tree: Vsx1

Human
homologs
VSX1, visual system homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 30813
neXtProt AC: NX_Q9NZR4

Human Synonyms: CAASDS, KTCN, KTCN1, PPCD, PPCD1, PPD, RINX

Human Chr (Location): 20p11.21; chr20:25070885-25082379 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human VSX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mutation of this locus impairs cone bipolar cell differentiation and affects retinal electrophysiology.
 
Interactions
Vsx1 interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process multicellular organismal development, neuron development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (103)    Tissues (103)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
RT-PCR 6
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA VSX1 ; Xenbase vsx1 ; ZFIN vsx1    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015757 (Evidence)
Ensembl Gene Model ENSMUSG00000033080 (Evidence)
Entrez Gene 114889 (Evidence)
UniGene 207061
DFCI TC1588095
DoTS DT.91371161
NIA Mouse Gene Index U023482
Consensus CDS Project CCDS16860.1
International Mouse Phenotyping Consortium Status Vsx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015757 VEGA Gene Model | MGI Sequence Detail 8659 C57BL/6J ±  kb
transcript OTTMUST00000037425 VEGA | MGI Sequence Detail 3791 Not Applicable 
polypeptide OTTMUSP00000016771 VEGA | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023339 CVC domain
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000017354 visual system homeobox 1
References
(Earliest) J:71130 Ohtoshi A, et al., Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina. Biochem Biophys Res Commun. 2001 Aug 10;286(1):133-40
(Latest) J:219894 Mattar P, et al., A conserved regulatory logic controls temporal identity in mouse neural progenitors. Neuron. 2015 Feb 4;85(3):497-504
All references(46)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory