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Npm2
Gene Detail
Symbol

Name
ID
Npm2
nucleophosmin/nucleoplasmin 2
MGI:1890811
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70647302-70653084 bp, - strand
From Ensembl annotation of GRCm38

  5783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: NPM2
Protein SuperFamily: nucleophosmin
Gene Tree: Npm2

Human
homologs
NPM2, nucleophosmin/nucleoplasmin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10361
neXtProt AC: NX_Q86SE8

Human Chr (Location): 8p21.3; chr8:22023708-22036897 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Female mice homozygous for disruptions in this gene display reduced fertility. While egg maturation and fertilization are grossly normal, cleavage to the two cell stage or beyond is apparently abnormal.
 
Interactions
Npm2 interacts with 34 markers (Mir31, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chromatin modification, chromatin remodeling, ...
Component cytoplasmic chromatin, nuclear chromatin, ...
Function chromatin binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (114)    Tissues (107)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 94
Western blot 8
RT-PCR 5
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase npm2 ; ZFIN npm2a    NEW 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000047911 (Evidence)
Entrez Gene 328440 (Evidence)
UniGene 347749
DFCI TC1585256
DoTS DT.91401682, DT.101364539
NIA Mouse Gene Index U035753
Consensus CDS Project CCDS27261.1
International Mouse Phenotyping Consortium Status Npm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047911 Ensembl Gene Model | MGI Sequence Detail 5783 C57BL/6J ±  kb
transcript ENSMUST00000062629 Ensembl | MGI Sequence Detail 997 Not Applicable 
polypeptide ENSMUSP00000057365 Ensembl | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004301 Nucleoplasmin
InterPro IPR024057 Nucleoplasmin core domain
Protein Ontology PR:000011371 nucleoplasmin-2
References
(Earliest) J:83658 Burns KH, et al., Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
(Latest) J:202816 Wajapeyee N, et al., Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15;27(20):2221-6
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory