Npm2
Gene Detail

Symbol Name ID

Npm2 nucleophosmin/nucleoplasmin 2 MGI:1890811

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:70647302-70653084 bp, - strand From NCBI annotation of GRCm38   5783 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: nucleophosmin
Gene Tree: Npm2

Human homologs

Human Homolog		NPM2, nucleophosmin/nucleoplasmin 2
NCBI Gene ID		10361
neXtProt AC		NX_Q86SE8
Human Chr (Location)		8p21.3; chr8:21882354-21894408 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(3)
 

Female mice homozygous for disruptions in this gene display reduced fertility. While egg maturation and fertilization are grossly normal, cleavage to the two cell stage or beyond is apparently abnormal.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	chromatin modification, chromatin remodeling, ...
Component	cytoplasmic chromatin, nuclear chromatin, ...
Function	enzyme binding, nucleic acid binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (123)    Tissues (109)    Images (9)
Theiler Stages: 1, 2, 3, 4, 5, 16, 22, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	94
Western blot	12
RT-PCR	10

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000047911 (Evidence)
Entrez Gene	328440 (Evidence)
UniGene	347749
DFCI	TC1585256
DoTS	DT.101364539, DT.91401682
NIA Mouse Gene Index	U035753
Consensus CDS Project	CCDS27261.1
International Mouse Knockout Project Status	Npm2

Sequences

Length	Strain/Species
genomic	328440	NCBI Gene Model | MGI Sequence Detail	5783	C57BL/6J
transcript	NM_181345	RefSeq | MGI Sequence Detail	997	C57BL/6
polypeptide	Q80W85	UniProt | EBI | MGI Sequence Detail	207	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004301	Nucleoplasmin
InterPro	IPR024057	Nucleoplasmin core
Protein Ontology	PR:000011371	nucleoplasmin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:83658 Burns KH, et al., Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(32)