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Slc9a3r2
Gene Detail
 Symbol
Name
ID
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
MGI:1890662
Synonyms 0610011L07Rik, 1200011K07Rik, 2010007A20Rik, E3karp, NHERF-2, Octs2, Sip1, Sip-1, Sryip1, Tka-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.43 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:24639282-24650305 bp, - strand
From NCBI annotation of GRCm38

  11024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Na(+)/H(+) exchange regulatory cofactor NHE-RF
Gene Tree: Slc9a3r2

Human
homologs
Human Homolog SLC9A3R2, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
NCBI Gene ID 9351
neXtProt AC  NX_Q15599
Human Synonyms  E3KARP, NHE3RF2, NHERF2, NHERF-2, OCTS2, SIP1, SIP-1, TKA-1
Human Chr (Location)  16p13.3; chr16:2026868-2039026 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
 
Mice homozygous for a null allele are viable, fertile and overtly normal and display normal cAMP- and cGMP-activated CFTR transepithelial chloride transport and bicarbonate secretion in the small intestine.
 
Interactions
Slc9a3r2 interacts with 149 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process negative regulation of phosphatidylinositol 3-kinase signaling, positive regulation of membrane potential
Component apical plasma membrane, cytoplasm, ...
Function beta-catenin binding, channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) cDNA(68)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000002504 (Evidence)
Entrez Gene65962 (Evidence)
UniGene21587
DFCITC1577274, TC1587990, TC1592700, TC1669884
DoTSDT.101174198, DT.110580710, DT.493126, DT.94404079
NIA Mouse Gene IndexU037531
Consensus CDS ProjectCCDS28488.1, CCDS28489.1
International Mouse Knockout Project StatusSlc9a3r2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 65962 NCBI Gene Model | MGI Sequence Detail 11024 C57BL/6J ±  kb
transcript NM_023055 RefSeq | MGI Sequence Detail 2118 C57BL/6 
polypeptide Q9JHL1 UniProt | EBI | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015098 EBP50, C-terminal
InterPro IPR017300 Na(+)/H(+) exchange regulatory cofactor NHE-RF
InterPro IPR001478 PDZ domain
Protein Ontology PR:000015215 Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Graphical View of Protein Domain Structure
References (Earliest) J:75423 Zhang J, et al., In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol. 1999 May;43(3):219-27
(Latest) J:183019 He P, et al., Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25
All references(51)
Other
accession IDs
MGI:1915060, MGI:1915601, MGI:1923770, MGI:2178113

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory