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Pdcl2 Gene Detail
Summary
  • Symbol
    Pdcl2
  • Name
    phosducin-like 2
  • Synonyms
    1700010B22Rik, 1700016K07Rik, Mgcphlp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890655
    NCBI Gene: 79455
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76459963-76479003 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 40.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890655
 protein coding gene Chr5:76459962-76479003 (-)
129S1/SvImJ ENSMUSG00200000692
 protein coding gene Chr5:72150150-72169179 (-)
A/J ENSMUSG00195010030
 protein coding gene Chr5:71446910-71465983 (-)
AKR/J ENSMUSG00220014866
 protein coding gene Chr5:71560087-71579153 (-)
BALB/cJ ENSMUSG00180023112
 protein coding gene Chr5:71221867-71240911 (-)
C3H/HeJ ENSMUSG00175004211
 protein coding gene Chr5:73265672-73284713 (-)
C57BL/6NJ ENSMUSG00215000440
 protein coding gene Chr5:72036449-72055493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027315
 protein coding gene Chr5:69214862-69235902 (-)
CAST/EiJ ENSTCUG00005013249
 protein coding gene Chr5:71007534-71026810 (-)
CBA/J ENSMUSG00210000449
 protein coding gene Chr5:72203677-72222717 (-)
DBA/2J ENSMUSG00185016403
 protein coding gene Chr5:74033624-74052662 (-)
FVB/NJ ENSMUSG00205018759
 protein coding gene Chr5:70969935-70989002 (-)
JF1/MsJ ENSUMUG00000004869
 protein coding gene Chr5:78503135-78522379 (-)
LP/J ENSMUSG00230021485
 protein coding gene Chr5:78724149-78743173 (-)
NOD/ShiLtJ ENSMUSG00190007654
 protein coding gene Chr5:71154067-71173109 (-)
NZO/HlLtJ ENSMUSG00225033168
 protein coding gene Chr5:83771105-83790145 (-)
PWK/PhJ ENSLUMG00010007271
 protein coding gene Chr5:71096522-71115709 (-)
SPRET/EiJ ENSMSPG00010008943
 protein coding gene Chr5:73086703-73105417 (-)
WSB/EiJ ENSIUOG00005018056
 protein coding gene Chr5:73983567-74002616 (-)



Homology
more
  • Human Ortholog
    PDCL2, phosducin like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDCL2, phosducin like 2
  • Synonyms
    GCPHLP
  • Links
    NCBI Gene ID: 132954
    UniProt: Q8N4E4

  • Chr Location
    4q12; chr4:55556519-55592245 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show male infertility, globozoospermia, abnormal acrosome biogenesis and lack of acrosomal cap formation, and sperm immobility and disrupted flagellum axonemes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    31
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 79455 NCBI Gene Model | MGI Sequence Detail 19041 C57BL/6J ±  kb
    transcript NM_023508 RefSeq | MGI Sequence Detail 1192 C57BL/6  
    polypeptide Q78Y63 UniProt | EBI | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913577, MGI:1916664
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338084 Fujihara Y, et al., PDCL2 is essential for sperm acrosome formation and male fertility in mice. Andrology. 2023 Jul;11(5):789-798
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory