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Brwd1 Gene Detail
Summary
  • Symbol
    Brwd1
  • Name
    bromodomain and WD repeat domain containing 1
  • Synonyms
    5330419I02Rik, D530019K20Rik, G1-403-16, repro5, Wdr9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890651
    NCBI Gene: 93871
  • Gene Overview
    MyGene.info: BRWD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:95992449-96082526 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.77 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BRWD1, bromodomain and WD repeat domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRWD1, bromodomain and WD repeat domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf107, DCAF19, N143, WDR9, WRD9
  • Links
    NCBI Gene ID: 54014
    neXtProt AC: NX_Q9NSI6
    UniProt: Q9NSI6

  • Chr Location
    21q22.2; chr21:39184176-39321595 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23130
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRWD1
  • Gene Tree
Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020395 VEGA Gene Model | MGI Sequence Detail 90078 C57BL/6J ±  kb
    transcript OTTMUST00000048365 VEGA | MGI Sequence Detail 8074 Not Applicable  
    polypeptide OTTMUSP00000022149 VEGA | MGI Sequence Detail 2643 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      343 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 30
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
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    MGI:1926107, MGI:2442152, MGI:3512790
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 5
      Phenotypes 37
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory