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Fignl1 Gene Detail
Summary
  • Symbol
    Fignl1
  • Name
    fidgetin-like 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890648
    NCBI Gene: 60530
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11750288-11758983 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 7.08 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890648
 protein coding gene Chr11:11737431-11758983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018046
 protein coding gene Chr11:9079945-9104104 (-)
A/J MGP_AJ_G0018019
 protein coding gene Chr11:8762655-8784796 (-)
AKR/J MGP_AKRJ_G0017983
 protein coding gene Chr11:9130450-9153072 (-)
BALB/cJ MGP_BALBcJ_G0017987
 protein coding gene Chr11:8784045-8805167 (-)
C3H/HeJ MGP_C3HHeJ_G0017800
 protein coding gene Chr11:9031842-9054245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018439
 protein coding gene Chr11:9387924-9413650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016097
 protein coding gene Chr11:8306299-8328813 (-)
CAST/EiJ MGP_CASTEiJ_G0017362
 protein coding gene Chr11:9041583-9066811 (-)
CBA/J MGP_CBAJ_G0017775
 protein coding gene Chr11:10060716-10090116 (-)
DBA/2J MGP_DBA2J_G0017885
 protein coding gene Chr11:8695961-8718404 (-)
FVB/NJ MGP_FVBNJ_G0017877
 protein coding gene Chr11:8606625-8627855 (-)
LP/J MGP_LPJ_G0017956
 protein coding gene Chr11:9185205-9208175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017903
 protein coding gene Chr11:9788109-9809497 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018480
 protein coding gene Chr11:9151285-9175889 (-)
PWK/PhJ MGP_PWKPhJ_G0017142
 protein coding gene Chr11:8731068-8753988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016939
 protein coding gene Chr11:8995528-9022827 (-)
WSB/EiJ MGP_WSBEiJ_G0017416
 protein coding gene Chr11:8913584-8936026 (-)



Homology
more
  • Human Ortholog
    FIGNL1, fidgetin like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIGNL1, fidgetin like 1
  • Links
    NCBI Gene ID: 63979
    neXtProt AC: NX_Q6PIW4
    UniProt: Q6PIW4

  • Chr Location
    7p12.2; chr7:50444128-50450390 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    7
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 60530 NCBI Gene Model | MGI Sequence Detail 8696 C57BL/6J ±  kb
transcript NM_001425652 RefSeq | MGI Sequence Detail 3020 C57BL/6  
polypeptide Q8BPY9 UniProt | EBI | MGI Sequence Detail 683 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:64964 Cox GA, et al., The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. Nat Genet. 2000 Oct;26(2):198-202
  • Latest
    J:344887 Zhang Q, et al., The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. Nucleic Acids Res. 2023 Sep 8;51(16):8606-8622
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory