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Fign Gene Detail
Summary
  • Symbol
    Fign
  • Name
    fidgetin
  • Synonyms
    Fgn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890647
    NCBI Gene: 60344
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:63971508-64098038 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 37.19 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890647
protein coding gene Chr2:63971507-64098038 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025775
protein coding gene Chr2:63701439-63833903 (-)
A/J MGP_AJ_G0025751
protein coding gene Chr2:61264952-61390981 (-)
AKR/J MGP_AKRJ_G0025721
protein coding gene Chr2:62907998-63036080 (-)
BALB/cJ MGP_BALBcJ_G0025746
protein coding gene Chr2:61405504-61542145 (-)
C3H/HeJ MGP_C3HHeJ_G0025507
protein coding gene Chr2:63051983-63180793 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026193
protein coding gene Chr2:65589838-65733399 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023597
protein coding gene Chr2:58705780-58831955 (-)
CAST/EiJ MGP_CASTEiJ_G0024971
protein coding gene Chr2:63119425-63252220 (-)
CBA/J MGP_CBAJ_G0025487
protein coding gene Chr2:68078871-68229634 (-)
DBA/2J MGP_DBA2J_G0025618
protein coding gene Chr2:60871774-60999375 (-)
FVB/NJ MGP_FVBNJ_G0025580
protein coding gene Chr2:60352348-60481148 (-)
LP/J MGP_LPJ_G0025706
protein coding gene Chr2:63549471-63681040 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025611
protein coding gene Chr2:69988044-70125300 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026250
protein coding gene Chr2:62961639-63101803 (-)
PWK/PhJ MGP_PWKPhJ_G0024712
protein coding gene Chr2:60722858-60851783 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024519
protein coding gene Chr2:63138683-63267861 (-)
WSB/EiJ MGP_WSBEiJ_G0025039
protein coding gene Chr2:63315464-63447634 (-)



Homology
more
  • Human Ortholog
    FIGN, fidgetin, microtubule severing factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FIGN, fidgetin, microtubule severing factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55137
    neXtProt AC: NX_Q5HY92
    UniProt: Q5HY92

  • Chr Location
    2q24.3; chr2:163602611-163736155 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5813
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FIGN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 2 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a reporter allele show pre- and postnatal death, head-shaking, and small eyes. Spontaneous mutants show head-shaking, circling, reduced or absent semicircular canals, small abnormal eyes, aberrant cell-cycling, female sterility, and low prenetrance craniofacial and skeletal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60344 NCBI Gene Model | MGI Sequence Detail 126531 C57BL/6J ±  kb
    transcript NM_001267846 RefSeq | MGI Sequence Detail 9817 C57BL/6  
    polypeptide Q9ERZ6 UniProt | EBI | MGI Sequence Detail 759 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9796, MGI:95533
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:13035 Gruneberg H, Two new mutant genes in the house mouse. J Genet. 1943;45:22-28
    • Latest
      J:265382 Wang D, et al., Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility. Circulation. 2017 May 2;135(18):1733-1748

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory