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Fign
Gene Detail
Symbol

Name
ID
Fign
fidgetin
MGI:1890647
Feature Type
protein coding gene
Genetic Map
Chromosome 2
37.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr2:63971507-64098038 bp, - strand
From VEGA annotation of GRCm38

  126532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5813  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fign

Human
homologs
Human Homolog FIGN, fidgetin
NCBI Gene ID 55137
neXtProt AC  NX_Q5HY92
Human Chr (Location)  2q24.3; chr2:163604937-163736108 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a reporter allele show pre- and postnatal death, head-shaking, and small eyes. Spontaneous mutants show head-shaking, circling, reduced or absent semicircular canals, small abnormal eyes, aberrant cell-cycling, female sterility, and low prenetrance craniofacial and skeletal defects.
 
Phenotype Images(1)
Interactions
Fign interacts with 570 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, microtubule-severing ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (8)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012785 (Evidence)
Ensembl Gene ModelENSMUSG00000075324 (Evidence)
Entrez Gene60344 (Evidence)
DFCITC1736668, TC1602973, TC1594439, TC1589230
DoTSDT.94214497, DT.91581770, DT.40184494, DT.110727610, DT.97370872
NIA Mouse Gene IndexU022683, U022681, U263995
Consensus CDS ProjectCCDS16070.1
International Mouse Knockout Project StatusFign
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012785 VEGA Gene Model | MGI Sequence Detail 126532 C57BL/6J ±  kb
transcript OTTMUST00000030613 VEGA | MGI Sequence Detail 9734 Not Applicable 
polypeptide OTTMUSP00000013744 VEGA | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(653 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000007522 fidgetin
References
(Earliest) J:13035 Gruneberg H, Two new mutant genes in the house mouse. J Genet. 1943;45:22-28
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(49)
Other
accession IDs
MGD-MRK-9796, MGI:95533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory