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Fign Gene Detail
Summary
  • Symbol
    Fign
  • Name
    fidgetin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890647
    NCBI Gene: 60344
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:63971507-64098038 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      126532 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 37.19 cM
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    FIGN, fidgetin, microtubule severing factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FIGN, fidgetin, microtubule severing factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55137
    neXtProt AC: NX_Q5HY92
    UniProt: Q5HY92

  • Chr Location
    2q24.3; chr2:163602611-163736155 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5813
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FIGN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 2 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a reporter allele show pre- and postnatal death, head-shaking, and small eyes. Spontaneous mutants show head-shaking, circling, reduced or absent semicircular canals, small abnormal eyes, aberrant cell-cycling, female sterility, and low prenetrance craniofacial and skeletal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012785 VEGA Gene Model | MGI Sequence Detail 126532 C57BL/6J ±  kb
    transcript OTTMUST00000030613 VEGA | MGI Sequence Detail 9734 Not Applicable  
    polypeptide OTTMUSP00000013744 VEGA | MGI Sequence Detail 759 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      651 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9796, MGI:95533
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:13035 Gruneberg H, Two new mutant genes in the house mouse. J Genet. 1943;45:22-28
    • Latest
      J:256105 Mendelsohn AI, et al., Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles. Neuron. 2017 Feb 22;93(4):792-805.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory