Nek8
Gene Detail

Symbol Name ID

Nek8 NIMA (never in mitosis gene a)-related expressed kinase 8 MGI:1890646

Synonyms

4632401F23Rik, b2b1449Clo

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:78166106-78176675 bp, - strand From VEGA annotation of GRCm38   10570 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nek8

Human homologs

Human Homolog		NEK8, NIMA-related kinase 8
NCBI Gene ID		284086
neXtProt AC		NX_Q86SG6
Human Synonyms		JCK, NEK12A, NPHP9
Human Chr (Location)		17q11.1; chr17:27055832-27069784 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NEK8

Alleles and phenotypes

All alleles(6) : Gene trapped(4) Spontaneous(1) Chemically induced(1)
 

Homozygous mutant mice display kidney cysts primarily in the cortex, progressive kidney enlargement, increased serum creatinine levels, impaired maternal nurturing, and premature death. Heterotaxy with congenital heart disease such as hypoplastic right ventricle and small tricuspid valve is seen.

 
Human Diseases Modeled Using Mouse Nek8 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(8)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	phosphorylation, protein phosphorylation
Component	cell projection, cilium, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (40)    Tissues (12)   
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	40

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000109 (Evidence)
Ensembl Gene Model	ENSMUSG00000017405 (Evidence)
Entrez Gene	140859 (Evidence)
UniGene	23788
DFCI	TC1579353, TC1616306
DoTS	DT.101335912, DT.110512770, DT.91335160, DT.94253303
NIA Mouse Gene Index	U033122
EC	2.7.11.1
Consensus CDS Project	CCDS25091.1
International Mouse Knockout Project Status	Nek8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000109	VEGA Gene Model | MGI Sequence Detail	10570	C57BL/6J
transcript	OTTMUST00000000369	VEGA | MGI Sequence Detail	2809	Not Applicable
polypeptide	OTTMUSP00000000162	VEGA | MGI Sequence Detail	698	Not Applicable

All sequences(47) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR009091	Regulator of chromosome condensation/beta-lactamase-inhibitor protein II
InterPro	IPR000408	Regulator of chromosome condensation, RCC1
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000011134	serine/threonine-protein kinase Nek8

References

(Earliest) J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
(Latest) J:192775 McCooke JK, et al., A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genomics. 2012;13:393
All references(50)

Other accession IDs

MGD-MRK-11520, MGI:1921589, MGI:5317582, MGI:96632