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Nek8
Gene Detail
 Symbol
Name
ID
Nek8
NIMA (never in mitosis gene a)-related expressed kinase 8
MGI:1890646
Synonyms 4632401F23Rik, b2b1449Clo
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78166106-78176675 bp, - strand
From VEGA annotation of GRCm38

  10570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nek8

Human
homologs
Human Homolog NEK8, NIMA-related kinase 8
NCBI Gene ID 284086
neXtProt AC  NX_Q86SG6
Human Synonyms  JCK, NEK12A, NPHP9, RHPD2
Human Chr (Location)  17q11.1; chr17:28728814-28742766 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NEK8
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(4) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display kidney cysts primarily in the cortex, progressive kidney enlargement, increased serum creatinine levels, impaired maternal nurturing, and premature death. Heterotaxy with congenital heart disease such as hypoplastic right ventricle and small tricuspid valve is seen.
 
Human Diseases Modeled Using Mouse Nek8 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(8)
Interactions
Nek8 interacts with 83 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process organ morphogenesis, phosphorylation, ...
Component cell projection, ciliary base, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (14)   
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 40
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000109 (Evidence)
Ensembl Gene ModelENSMUSG00000017405 (Evidence)
Entrez Gene140859 (Evidence)
UniGene23788
DFCITC1579353, TC1616306
DoTSDT.101335912, DT.110512770, DT.91335160, DT.94253303
NIA Mouse Gene IndexU033122
EC2.7.11.1
Consensus CDS ProjectCCDS25091.1
International Mouse Knockout Project StatusNek8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000109 VEGA Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
transcript OTTMUST00000000369 VEGA | MGI Sequence Detail 2809 Not Applicable 
polypeptide OTTMUSP00000000162 VEGA | MGI Sequence Detail 698 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011134 serine/threonine-protein kinase Nek8
References (Earliest) J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
(Latest) J:205163 Hoff S, et al., ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet. 2013 Aug;45(8):951-6
All references(57)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11520, MGI:1921589, MGI:5317582, MGI:96632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory