About   Help   FAQ
Nek8
Gene Detail
Symbol

Name
ID
Nek8
NIMA (never in mitosis gene a)-related expressed kinase 8
MGI:1890646
Synonyms
4632401F23Rik, b2b1449Clo
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78166106-78176675 bp, - strand
From VEGA annotation of GRCm38

  10570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEK8
Gene Tree: Nek8

Human
homologs
NEK8, NIMA-related kinase 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 284086
neXtProt AC: NX_Q86SG6

Human Synonyms: JCK, NEK12A, NPHP9, RHPD2

Human Chr (Location): 17q11.1; chr17:28725897-28742766 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NEK8

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(4) Spontaneous(1) Targeted(2)
Genomic Mutations involving Nek8 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice display kidney cysts primarily in the cortex, progressive kidney enlargement, increased serum creatinine levels, impaired maternal nurturing, and premature death. Heterotaxy with congenital heart disease such as hypoplastic right ventricle and small tricuspid valve is seen.
 
Human Diseases Modeled in Mice Using Nek8 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(8)
Interactions
Nek8 interacts with 82 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process microtubule-based process, organ morphogenesis, ...
Component cell projection, ciliary base, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 40
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nek8 ; ZFIN nek8    NEW 
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000109 (Evidence)
Ensembl Gene Model ENSMUSG00000017405 (Evidence)
Entrez Gene 140859 (Evidence)
UniGene 23788
DFCI TC1579353, TC1616306
DoTS DT.101335912, DT.110512770, DT.91335160, DT.94253303
NIA Mouse Gene Index U033122
EC 2.7.11.1
Consensus CDS Project CCDS25091.1
International Mouse Phenotyping Consortium Status Nek8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000109 VEGA Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
transcript OTTMUST00000000369 VEGA | MGI Sequence Detail 2809 Not Applicable 
polypeptide OTTMUSP00000000162 VEGA | MGI Sequence Detail 698 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011134 serine/threonine-protein kinase Nek8
References
(Earliest) J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(61)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11520, MGI:1921589, MGI:5317582, MGI:96632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory