About   Help   FAQ
Nek8 Gene Detail
Summary
  • Symbol
    Nek8
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 8
  • Synonyms
    4632401F23Rik, b2b1449Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890646
    NCBI Gene: 140859
  • Gene Overview
    MyGene.info: NEK8
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78166106-78176675 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890646
protein coding gene Chr11:78166106-78176699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018765
protein coding gene Chr11:79147776-79158305 (-)
A/J MGP_AJ_G0018731
protein coding gene Chr11:76124897-76135462 (-)
AKR/J MGP_AKRJ_G0018701
protein coding gene Chr11:78429056-78440573 (-)
BALB/cJ MGP_BALBcJ_G0018705
protein coding gene Chr11:76534127-76544680 (-)
C3H/HeJ MGP_C3HHeJ_G0018518
protein coding gene Chr11:78470276-78481658 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019156
protein coding gene Chr11:81619373-81629923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016791
protein coding gene Chr11:73098694-73109440 (-)
CAST/EiJ MGP_CASTEiJ_G0018072
protein coding gene Chr11:78908328-78918795 (-)
CBA/J MGP_CBAJ_G0018488
protein coding gene Chr11:85178620-85191841 (-)
DBA/2J MGP_DBA2J_G0018597
protein coding gene Chr11:75706938-75717608 (-)
FVB/NJ MGP_FVBNJ_G0018587
protein coding gene Chr11:75294162-75305458 (-)
LP/J MGP_LPJ_G0018668
protein coding gene Chr11:79683488-79694045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018613
protein coding gene Chr11:85603620-85614018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019196
protein coding gene Chr11:78672859-78683417 (-)
PWK/PhJ MGP_PWKPhJ_G0017843
protein coding gene Chr11:76488737-76499305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017634
protein coding gene Chr11:78280814-78291188 (-)
WSB/EiJ MGP_WSBEiJ_G0018125
protein coding gene Chr11:78486604-78496984 (-)



Homology
more
  • Human Ortholog
    NEK8, NIMA related kinase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEK8, NIMA related kinase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JCK, NEK12A, NPHP9, RHPD2
  • Links
    NCBI Gene ID: 284086
    neXtProt AC: NX_Q86SG6
    UniProt: Q86SG6

  • Chr Location
    17q11.2; chr17:28727899-28743457 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 84442
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEK8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Nek8 mouse models; 2 with human NEK8 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice display kidney cysts primarily in the cortex, progressive kidney enlargement, increased serum creatinine levels, impaired maternal nurturing, and premature death. Heterotaxy with congenital heart disease such as hypoplastic right ventricle and small tricuspid valve is seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017405 Ensembl Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
    transcript ENSMUST00000017549 Ensembl | MGI Sequence Detail 2809 Not Applicable  
    polypeptide ENSMUSP00000017549 Ensembl | MGI Sequence Detail 698 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11520, MGI:1921589, MGI:5317582, MGI:96632
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261989 Nakajima Y, et al., The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. Kidney Int. 2018 May;93(5):1108-1117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory