Panx2
Gene Detail

Symbol Name ID

Panx2 pannexin 2 MGI:1890615

Feature Type

protein coding gene

Genetic Map

Chromosome 15

44.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:89059734-89073567 bp, + strand From VEGA annotation of GRCm38   13834 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Panx2

Human homologs

Human Homolog		PANX2, pannexin 2
NCBI Gene ID		56666
neXtProt AC		NX_Q96RD6
Human Synonyms		hPANX2, PX2
Human Chr (Location)		22q13.33; chr22:50609160-50618724 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit a slight protection from the neurological defects induced by ischemic brain injury.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell-cell signaling, ion transport, ...
Component	cell junction, cytoplasm, ...
Function	channel activity, gap junction channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1) cDNA(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033329 (Evidence)
Ensembl Gene Model	ENSMUSG00000058441 (Evidence)
Entrez Gene	406218 (Evidence)
DFCI	TC1604962, TC1611009
DoTS	DT.101159642, DT.55283317
NIA Mouse Gene Index	U203896, U324918
Consensus CDS Project	CCDS49695.1
International Mouse Knockout Project Status	Panx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033329	VEGA Gene Model | MGI Sequence Detail	13834	C57BL/6J
transcript	OTTMUST00000083637	VEGA | MGI Sequence Detail	3391	Not Applicable
polypeptide	OTTMUSP00000044968	VEGA | MGI Sequence Detail	677	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000990	Innexin
Protein Ontology	PR:000012260	pannexin-2

References

(Earliest) J:89297 Baranova A, et al., The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics. 2004 Apr;83(4):706-16
(Latest) J:180516 Bargiotas P, et al., Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20772-7
All references(27)