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Panx2 Gene Detail
Summary
  • Symbol
    Panx2
  • Name
    pannexin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890615
    NCBI Gene: 406218
Location & Maps
more
  • Sequence Map
    Chr15:89059734-89073567 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13834 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.57 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PANX2, pannexin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PANX2, pannexin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hPANX2, PX2
  • Links
    NCBI Gene ID: 56666
    neXtProt AC: NX_Q96RD6

  • Chr Location
    22q13.33; chr22:50170731-50180295 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 14155
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PANX2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Panx2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit a slight protection from the neurological defects induced by ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033329 VEGA Gene Model | MGI Sequence Detail 13834 C57BL/6J ±  kb
transcript OTTMUST00000083637 VEGA | MGI Sequence Detail 3391 Not Applicable  
polypeptide OTTMUSP00000044968 VEGA | MGI Sequence Detail 677 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:89297 Baranova A, et al., The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics. 2004 Apr;83(4):706-16
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory